DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Raf and Ripk3

DIOPT Version :9

Sequence 1:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_647558.2	Gene:	Ripk3 / 246240	RGDID:	628899	Length:	478	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	99/340 - (29%)
Similarity:	155/340 - (45%)	Gaps:	69/340 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   417 SSEENWNILAEEI-LIGPR-------IGSGSFGTVYRAH---WHGPVAVKTLNVKTPSPAQLQAF 470
            ||.:.|...|..| |:|..       :|.|.||.|:||.   |:..||||.:|.|..|
  Rat     2 SSVKLWLNGASSISLVGSEELENLGFVGKGGFGAVFRARHTAWNLDVAVKIVNSKKIS------- 59

  Fly   471 KNEVAMLKKTRHCNILLFMGC--------VSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLID 527
             .||..:...||.|:||.:|.        |..|  |:||.:.|..||...:..|..: ....|..
  Rat    60 -REVKAMVNLRHENVLLLLGVTENLEWDYVYGP--ALVTGFMENGSLSGLLQPSCPR-PWPLLCR 120

  Fly   528 IGRQVAQGMDYLHAKN--IIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGS-- 588
            :..:|..||.|||:.|  ::|||||.:|:.|..:|..|:.||||:|    :.|..|:...:||
  Rat   121 LLEEVVLGMCYLHSLNPSLLHRDLKPSNVLLDPELHAKLADFGLST----FQGGSQSGSGSGSRD 181

  Fly   589 ----ILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLA---------ECLPYGHISNKDQILFM 640
                :.::|||:  :......|..||||:||::::.:||         ..|..|.:.|:.:
  Rat   182 SGGTLAYLAPEL--LDNDGKASKASDVYSFGVLVWTVLAGREAEVVDKTSLIRGAVCNRQR---- 240

  Fly   641 VGRGLLRPDMSQVRSDAP-----QALKRLAEDCIKYTPKDRPLFRPLLNMLENM-LRTLPKIHRS 699
                  ||.::::..|:|     :.||.|...|....|||||.|:...:...|: :....|:..:
  Rat   241 ------RPPLTELPPDSPETPGLEGLKELMTHCWSSEPKDRPSFQDCESKTNNVYILVQDKVDAA 299

  Fly   700 ASEPNLTQSQLQNDE 714
            .|:.....||.::.:
  Rat   300 VSKVKHYLSQYRSSD 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514
		C1_Raf	221..269	CDD:410361
		STKc_Raf	435..687	CDD:270964	87/284 (31%)
Ripk3	NP_647558.2	PKc_like	28..285	CDD:419665	87/283 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..330		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..429
		RHIM	408..458	CDD:403811
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000250\|UniProtKB:Q9Y572	437..461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000