DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Raf and lin-45

DIOPT Version :9

Sequence 1:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001379593.1	Gene:	lin-45 / 177436	WormBaseID:	WBGene00003030	Length:	855	Species:	Caenorhabditis elegans

Alignment Length:	804	Identity:	296/804 - (36%)
Similarity:	405/804 - (50%)	Gaps:	190/804 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 RLNSQDQQEDSSLVERFKEQPHYQNQTQILQQQRQLARVHHGNDLTDSLGSQPGSQCGTLTRQP- 139
            ||.|..:...||:..:.:..|.....|.:..:        |.:.|....|.......||..::|
Worm    66 RLISLPRCASSSIDRKDQASPMASPSTPLYPK--------HSDSLHSLSGHHSAGGAGTSDKEPP 122

  Fly   140 ----KILLRAHLPNQQRTSVEVISGVRLCDALMKALKLRQLTPDMCEVSTTHSGRHIIPWHTDIG 200
                |::: .|||..|.:.|||..|....||:.|.||.|.:||.:|.|:.:..     |....|.
Worm   123 KFKYKMIM-VHLPFDQHSRVEVRPGETARDAISKLLKKRNITPQLCHVNASSD-----PKQESIE 181

  Fly   201 -TLHVEEIFVRL--------LDKFPIRTHIKHQIIRKTFFSLVFCEGCRR-LLFTGFYCSQCNFR 255
             :|.:|||..||        .:.....:.|||.|:|:||.....|:.|.. :...||.|..|.|:
Worm   182 LSLTMEEIASRLPGNELWVHSEYLNTVSSIKHAIVRRTFIPPKSCDVCNNPIWMMGFRCEFCQFK 246

  Fly   256 FHQRCANRVPMLCQ-----PFPMDSYYQLL----LAENPDNGVGFPGRGTAVRFNMSSRSRSRRC 311
            |||||::..|:.|.     |...|...:|.    ..|.||..|     ...|..|::
Worm   247 FHQRCSSFAPLYCDLLQSVPKNEDLVKELFGIASQVEGPDRSV-----AEIVLANLA-------- 298

  Fly   312 SSSGSSSSSKPPSS---------SSGNHR-------QGRPPRISQD-----DRSNSAPNV-CINN 354
            .:||.|.::.|.||         :.|..|       |....::|..     |||:||||: .||:
Worm   299 PTSGQSPAATPDSSHPDLTSIKRTGGVKRHPMAVSPQNETSQLSPSGPYPRDRSSSAPNINAIND 363

  Fly   355 IRSV--------TSEVQR----------SLI-MQAR----------------------------- 371
            ..:|        ..|.||          ||: .|||
Worm   364 EATVQHNQRILDALEAQRLEEESRDKTGSLLSTQARHRPHFQSGHILSGARMNRLHPLVDCTPLG 428

  Fly   372 ----------PP---LPHPCTDHSNSTQASPTSTL----KHNRP-------------------RA 400
                      ||   :..|....|.:...|.||:|    .|..|                   |:
Worm   429 SNSPSSTCSSPPGGLIGQPTLGQSPNVSGSTTSSLVAAHLHTLPLTPPQSAPPQKISPGFFRNRS 493

  Fly   401 RSADESNKNLLLRDA-------KSSEENWNILAEEILIGPRIGSGSFGTVYRAHWHGPVAVKTLN 458
            ||..|.      .||       |...|:|.||..|.:|..::||||||||||..:.|.||:|.||
Worm   494 RSPGER------LDAQRPRPPQKPHHEDWEILPNEFIIQYKVGSGSFGTVYRGEFFGTVAIKKLN 552

  Fly   459 VKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEGSSLYKHVHVSE--TKFK 521
            |..|:|:|:.|||||||:||||||.|:|||||.|.:|.:||:||||||||||:|:||.|  .:|:
Worm   553 VVDPTPSQMAAFKNEVAVLKKTRHLNVLLFMGWVREPEIAIITQWCEGSSLYRHIHVQEPRVEFE 617

  Fly   522 LNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLS-VKIGDFGLATAKTRW--SGEKQAN 583
            :..:|||.:||:.||:|||:|||||||||:|||||.:|:| ||||||||||.||:|  :|.:|..
Worm   618 MGAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQ 682

  Fly   584 QPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRP 648
            |||||||||||||||||:.|||:.|||||:|||.|||:|:..|||.:|:|:||||||||||.|||
Worm   683 QPTGSILWMAPEVIRMQDDNPYTPQSDVYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLRP 747

  Fly   649 DMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIHRSASEPN--------- 704
            |.|::|.|.|:::.:|.::||.:...:||:|..:|..|.:::  |||:.||.|.||
Worm   748 DRSKIRHDTPKSMLKLYDNCIMFDRNERPVFGEVLERLRDII--LPKLTRSQSAPNVLHLDSQYS 810

  Fly   705 ----LTQSQLQNDEFLYLPSPKTP 724
                :.:||:.:..::...:.|||
Worm   811 VMDAVMRSQMLSWSYIPPATAKTP 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514	26/78 (33%)
		C1_Raf	221..269	CDD:410361	20/48 (42%)
		STKc_Raf	435..687	CDD:270964	161/256 (63%)
lin-45	NP_001379593.1	RBD	128..203	CDD:128731	26/80 (33%)
		C1_Raf	211..260	CDD:410361	20/48 (42%)
		STKc_Raf	529..786	CDD:270964	161/256 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	334	1.000	Domainoid score	I600
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3197
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2247
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129822at33208
OrthoFinder	1	1.000	-	-		FOG0001587
OrthoInspector	1	1.000	-	-		oto18893
orthoMCL	1	0.900	-	-		OOG6_100006
Panther	1	1.100	-	-	LDO	PTHR44329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2599
SonicParanoid	1	1.000	-	-		X994
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900