DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Raf and Ksr1

DIOPT Version :9

Sequence 1:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_011247072.1	Gene:	Ksr1 / 16706	MGIID:	105051	Length:	914	Species:	Mus musculus

Alignment Length:	841	Identity:	209/841 - (24%)
Similarity:	343/841 - (40%)	Gaps:	203/841 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DPLAEELHNVQ--LVKHVTRENIDALNA----KFANLQEPPA----MYLIEY---------QELT 60
            |...:|:..::  |||::.::....|:.    :.|.|...|.    :|:...         ||||
Mouse    65 DLTQQEIRTLEAKLVKYICKQQQSKLSVTPSDRTAELNSYPRFSDWLYIFNVRPEVVQEIPQELT 129

  Fly    61 -SKLHEL-EAKEQELMERLNSQDQQEDSSLVERFKEQPHYQNQTQILQQQRQLARVH---HGNDL 120
             ..|.|: |||.:|::.|..:..:           |....|.....|::...|...|   .|...
Mouse   130 LDALLEMDEAKAKEMLRRWGASTE-----------ECSRLQQALTCLRKVTGLGGEHKMDSGWSS 183

  Fly   121 TDSLGSQPG---------SQCGTLTRQPKILLRAHLPNQQRTSVEVISGVR--LCDALMKALKLR 174
            ||:..|..|         .:.|..|:.|:.:..:.||    .|...:.|:.  |.|:.:......
Mouse   184 TDARDSSLGPPMDMLSSLGRAGASTQGPRSISVSALP----ASDSPVPGLSEGLSDSCIPLHTSG 244

  Fly   175 QLTPD-----MCEVSTTHSGRH------------------IIPWHTDIGTL-----HVEEIFVRL 211
            :|||.     :...:|....||                  ::|   ...||     |..::..|:
Mouse   245 RLTPRALHSFITPPTTPQLRRHAKLKPPRTPPPPSRKVFQLLP---SFPTLTRSKSHESQLGNRI 306

  Fly   212 LDKFPIRTHIKH---QIIR-------------KTFFSLVFCEGCRRLLFTGFYCSQCNFRFHQRC 260
            .|..|::..:.|   |::|             |::.|.| |..|::.:..|..|..|..:.|.:|
Mouse   307 DDVTPMKFELPHGSPQLVRRDIGLSVTHRFSTKSWLSQV-CNVCQKSMIFGVKCKHCRLKCHNKC 370

  Fly   261 ANRVPMLC-------------QPFPMDSYYQLLLAENPDNGVGFPGRGT------------AVRF 300
            ....| .|             :..|.|       ..||.:....|..||            |:..
Mouse   371 TKEAP-ACRITFLPLARLRRTESVPSD-------INNPVDRAAEPHFGTLPKALTKKEHPPAMNL 427

  Fly   301 NMSSRSRSRRCS----------SSGSSSSSKPPSSSSG--------------NHR---------- 331
            :.||...|...|          ||..||::.||:.|.|              :||
Mouse   428 DSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSPGQRDSRFSFPAAYFIHHRQQFIFPDISA 492

  Fly   332 --QGRPPRISQDD-RSNSAPNVCINNIRSVTSEVQRSLIMQARPPLPHPCTDHSNSTQASPTSTL 393
              |..|...:.|. |.:..|...:..:....:|...:...:|.       .|..:.....|:|..
Mouse   493 CSQAAPLSSTADSTRLDDQPKTDVLGVHEAEAEEPEAGKSEAE-------DDEEDEVDDLPSSRR 550

  Fly   394 KHNRPRARSADESNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHWHGPVAVKTLN 458
            ....|.:|.|.:::..|         :.|:|..|::.:|..||.|.:|.|:|..|||.||::.|.
Mouse   551 PWRGPISRKASQTSVYL---------QEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLE 606

  Fly   459 VKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLYKHVHVSETKFKL 522
            :...:...|:.||.||...::|||.|::|||| |::.|.|||:|.:|:|.:|:..|...:|...:
Mouse   607 MDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDI 671

  Fly   523 NTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTG 587
            |....|.:::.:||.|||||.|:|:||||.|:| :::..|.|.||||.........|::.||...
Mouse   672 NKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVF-YDNGKVVITDFGLFGISGVVREERRENQLKL 735

  Fly   588 SILW---MAPEVIRM------QELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGR 643
            |..|   :|||::|.      ::..|:|..:||||||.|.|||.|...|:.| ...:.:::.:|.
Mouse   736 SHDWLCYLAPEIVREMIPGRDEDQLPFSKAADVYAFGTVWYELQARDWPFKH-QPAEALIWQIGS 799

  Fly   644 GL-LRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIHRSASEP 703
            |. :|..::.|  ...:.:..:...|..:..::||.|..|::|||.    |||::|..|.|
Mouse   800 GEGVRRVLASV--SLGKEVGEILSACWAFDLQERPSFSLLMDMLER----LPKLNRRLSHP 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514	17/99 (17%)
		C1_Raf	221..269	CDD:410361	15/76 (20%)
		STKc_Raf	435..687	CDD:270964	93/262 (35%)
Ksr1	XP_011247072.1	KSR1-SAM	39..166	CDD:372630	23/111 (21%)
		C1	334..376	CDD:237996	11/43 (26%)
		STKc_KSR1	576..854	CDD:271054	101/285 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910