DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Raf and Braf

DIOPT Version :9

Sequence 1:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_038964558.1	Gene:	Braf / 114486	RGDID:	619908	Length:	847	Species:	Rattus norvegicus

Alignment Length:	835	Identity:	356/835 - (42%)
Similarity:	456/835 - (54%)	Gaps:	168/835 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SDLYDP-LAEELHNVQLVKHVTRENIDALNAKFANLQEPPAMYLIEYQELTSKLHELEAKEQELM 74
            |...|| :.||:.|::.:..:|:|:|:||..||.....||::||..|:|.||||..|:.:||:|:
  Rat    52 SSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLL 116

  Fly    75 ERLNSQDQQEDSSLVERFKEQPHYQNQTQILQQQRQLARVHHGNDLTDSLGSQPGSQCGTLTRQP 139
            |.|.:......||............:...:|.....:.:..     ||...:.|.|       ..
  Rat   117 ESLGNGADFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQTP-----TDVSRNNPKS-------PQ 169

  Fly   140 KILLRAHLPNQQRTSVEVISGVRLCDALMKALKLRQLTPDMCEVSTTHSG----RHIIPWHTDIG 200
            |.::|..|||:|||.|....||.:.|:|.|||.:|.|.|:.|.|.....|    :..|.|.|||.
  Rat   170 KPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGYALEKKPIGWDTDIS 234

  Fly   201 TLHVEEIFVRLLDKFPIRTHIKHQIIRKTFFSLVFCEGCRRLLFTGFYCSQCNFRFHQRCANRVP 265
            .|..||:.|.:|:..|:.|   |..:|||||:|.||:.||:|||.||.|..|.::|||||:..||
  Rat   235 WLTGEELHVEVLENVPLTT---HNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVP 296

  Fly   266 MLC-----------------QPFPMDSYYQLLLAENPDNGVGFPGRGTAVRFNMSSRSRSRRCSS 313
            ::|                 .|.|.:..:.   ||                            ::
  Rat   297 LMCVNYDQLDLLFVSKFFEHHPVPQEEAFS---AE----------------------------TT 330

  Fly   314 SGSSSSSKPPSSSSG------------------------NHRQGRPPRISQDDRSNSAPNVCINN 354
            ..|..||.|||.|.|                        :||.    :..|.|||:|||||.||.
  Rat   331 LPSGCSSAPPSDSIGPQILTSPSPSKSIPIPQPFRPADEDHRN----QFGQRDRSSSAPNVHINT 391

  Fly   355 IRSVT-----SEV----QRSLI---------------------MQARPPLP-------------H 376
            |..|.     .||    ||.||                     .|:|.|.|             .
  Rat   392 IEPVNIDEKFPEVELQDQRDLIRDQGFRGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFE 456

  Fly   377 PCTDHSNST---QASPTSTLKHN--------------RPRARSADESN-------KNLLLRDAKS 417
            |......||   .|:|.::|..:              |.|..|:..|:       |.|..||
  Rat   457 PGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSSSTEDRSRMKTLGRRD--- 518

  Fly   418 SEENWNILAEEILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRH 482
            |.::|.|...:|.:|.|||||||||||:..|||.||||.|||..|:|.|||||||||.:|:||||
  Rat   519 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRH 583

  Fly   483 CNILLFMGCVSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHR 547
            .|||||||..:||.||||||||||||||.|:|:.||||::..||||.||.||||||||||:||||
  Rat   584 VNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHR 648

  Fly   548 DLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVY 612
            |||||||||||||:||||||||||.|:||||..|..|.:||||||||||||||:.||||||||||
  Rat   649 DLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVY 713

  Fly   613 AFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRP 677
            |||||:|||:...|||.:|:|:|||:||||||.|.||:|:|||:.|:|:|||..:|:|....:||
  Rat   714 AFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERP 778

  Fly   678 LFRPLLNMLENMLRTLPKIHRSASEPNLTQSQLQNDEF-LY-LPSPKTPVNFNNF 730
            ||..:|..:|.:.|:|||||||||||:|.::..|.::| || ..|||||:....:
  Rat   779 LFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGY 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514	30/73 (41%)
		C1_Raf	221..269	CDD:410361	26/64 (41%)
		STKc_Raf	435..687	CDD:270964	180/251 (72%)
Braf	XP_038964558.1	RBD_BRAF	170..251	CDD:340654	32/80 (40%)
		C1_B-Raf	249..308	CDD:410421	28/61 (46%)
		STKc_Raf	536..788	CDD:270964	180/251 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	378	1.000	Domainoid score	I820
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3197
Inparanoid	1	1.050	578	1.000	Inparanoid score	I997
OMA	1	1.010	-	-		QHG49873
OrthoDB	1	1.010	-	-		D129822at33208
OrthoFinder	1	1.000	-	-		FOG0001587
OrthoInspector	1	1.000	-	-		otm45113
orthoMCL	1	0.900	-	-		OOG6_100006
Panther	1	1.100	-	-	LDO	PTHR44329
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X994
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980