Protein Alignment Raf and ksr1

DIOPT Version :9

• Sequence 1: NP_001096867.3
• Gene: Raf / 31221
• FlyBaseID: FBgn0003079
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: XP_031751648.1
• Gene: ksr1 / 100494230
• XenbaseID: XB-GENE-1004628
• Length: 885
• Species: Xenopus tropicalis
• Alignment Length: 841
• Identity: 203/841 - (24%)
• Similarity: 325/841 - (38%)
• Gaps: 225/841 - (26%)

  Fly    14 YDPLAEELHNV----QLVKHVTRE-NIDALNAKFANLQEPPAMYLIEYQELTSKLHELEAKE--- 70
            |..:::.||.:    ::|..|:.| .:|||                      .:|:||:.||
 Frog   101 YPRVSDWLHTISVRNEVVHKVSEELTLDAL----------------------LELNELKVKETMK 143

  Fly    71 -----QELMERLNSQDQQEDSSLVERFKEQPHYQNQTQILQQQRQLARVHHGNDLTDSLGSQP-- 128
                 .|...|||.                        .|...::|||  .|.|:.|:|.:.|
 Frog   144 KCGANTEECSRLNG------------------------ALTCLKKLAR--SGGDMKDTLWNPPEM 182

  Fly   129 ------------GSQCG-----------TLTRQPKILLRAHLPNQQRTSV-EVISGVRLCDALMK 169
                        .|..|           |.:.||:.:..:.:|..:.:|. ..|....|.|....
 Frog   183 RKESSSQVPSDISSPVGAAWTLNSQPPKTNSHQPRSISVSAIPFSESSSQGPYIYAENLQDPFSS 247

  Fly   170 ALKLRQLTPDMCEVSTTHS--------------------------GR----HIIPWHTDIGTL-- 202
            :..:.:||     :.|.|.                          ||    .::|   :..||
 Frog   248 STPISRLT-----LRTPHGFTITPPTTPQLKRAIKLKPPRTPPPPGRKVFQQLLP---NFSTLKR 304

  Fly   203 ---HVEEIFVRLLDKFP-----------------IRTHIKHQIIRKTFFSLVFCEGCRRLLFTGF 247
               |..::..| :|:.|                 |...:.|:...|::.|.: |..|::.:..|.
 Frog   305 SKSHESQLGNR-IDEVPSLKFDLPQGSPQMVRRDIGLSVTHRFSTKSWLSQM-CHVCQKSMMFGV 367

  Fly   248 YCSQCNFRFHQRCANRVPMLC-------------QPFPMDSYYQLLLAENPDNGVGFPGRGTAVR 299
            .|..|..:.|.:|....|. |             :..|.|...|:.....|..|. .|...|...
 Frog   368 KCKHCKLKCHNKCTKDAPS-CRISFLPIAKIRRTESVPSDINNQVDRPAEPHFGT-LPKALTKKE 430

  Fly   300 FNMSSR---SRSRRCSSSGSSSSSKPPSSSSGNHRQGRPPRIS----QDDRSNSA---------- 347
            .:.:..   |.|...|::.|:.||..|..||.......||..|    :|.|.|..
 Frog   431 HSPAINHLDSSSNPSSTTSSTPSSPAPFQSSNPSSAITPPNPSPIGPRDSRFNFPAAYYIQHRQQ 495

  Fly   348 ---PNVCINNIRSVTSEVQRSLIMQARPPLPHPCTD------------HSNSTQASPTSTLKHNR 397
               |.|.:....|..||...:...:|...     ||            .:|.::...........
 Frog   496 FIFPEVSVTAQASHVSETSENSSAEAEME-----TDVAEEQEAEVEEQDANKSEPEYDDDELDEL 555

  Fly   398 PRARSADESNKNLLLRDAKSSE---ENWNILAEEILIGPRIGSGSFGTVYRAHWHGPVAVKTLNV 459
            |.:|....:.:.:::|.|..:.   :.|:|..|:|.:|..||.|.:|.|:|..|||.||::.|.:
 Frog   556 PNSRYTSGTFRGMIIRKASQTSVYLQEWDIPFEQIELGELIGQGRWGKVFRGKWHGEVAIRLLEI 620

  Fly   460 KTPSPAQLQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLYKHVHVSETKFKLN 523
            ...:...|:.||.||...::|||.|::|||| |:..|.|||:|.:|:|.:||..|...:|...:|
 Frog   621 DGNNQDHLKLFKKEVMNYRQTRHENVVLFMGACMHPPHLAIITSFCKGRTLYSFVRDPKTSLDIN 685

  Fly   524 TLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGS 588
            ....|.:::.:||.|||||.|:|:||||.|:| :|:..|.|.||||..........::.|:...|
 Frog   686 KTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVF-YENGKVVITDFGLFGISGVVQEGRRENELKLS 749

  Fly   589 ILW---MAPEVIRM------QELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGRG 644
            ..|   :|||::|.      ::..|:|..:|:||||.:.|||.|...|... ...:.:::.:|.|
 Frog   750 HDWLCYLAPEIVREMTPGKGEDTLPFSKAADIYAFGTIWYELQARDWPLKR-QAAEALIWQIGSG 813

  Fly   645 LLRPDMSQVRS--DAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIHRSASEP 703
               ..|.||.|  ...:.:..:...|..:...:||.|..|::|||.    |||::|..|.|
 Frog   814 ---EGMKQVLSTISLGKEVTEILAACWAFDVNERPSFTLLMDMLEK----LPKLNRRLSHP 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514	16/105 (15%)
		C1_Raf	221..269	CDD:410361	12/60 (20%)
		STKc_Raf	435..687	CDD:270964	92/263 (35%)
ksr1	XP_031751648.1	KSR1-SAM	18..163	CDD:404435	19/107 (18%)
		C1_KSR1	342..388	CDD:410422	11/47 (23%)
		STKc_KSR1	589..867	CDD:271054	101/286 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910