Protein Alignment Raf and ksr1

DIOPT Version :10

• Sequence 1: NP_525047.1
• Gene: Raf / 31221
• FlyBaseID: FBgn0003079
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: XP_031751648.1
• Gene: ksr1 / 100494230
• XenbaseID: XB-GENE-1004628
• Length: 885
• Species: Xenopus tropicalis
• Alignment Length: 847
• Identity: 202/847 - (23%)
• Similarity: 324/847 - (38%)
• Gaps: 237/847 - (27%)

  Fly    14 YDPLAEELHNV----QLVKHVTRE-NIDALNAKFANLQEPPAMYLIEYQELTSKLHELEAKE--- 70
            |..:::.||.:    ::|..|:.| .:|||                      .:|:||:.||
 Frog   101 YPRVSDWLHTISVRNEVVHKVSEELTLDAL----------------------LELNELKVKETMK 143

  Fly    71 -----QELMERLNSQDQQEDSSLVERFKEQPHYQNQTQILQQQRQLARVHHGNDLTDSLGSQP-- 128
                 .|...|||.                        .|...::|||  .|.|:.|:|.:.|
 Frog   144 KCGANTEECSRLNG------------------------ALTCLKKLAR--SGGDMKDTLWNPPEM 182

  Fly   129 ------------GSQCG-----------TLTRQPKILLRAHLPNQQR----------------TS 154
                        .|..|           |.:.||:.:..:.:|..:.                :|
 Frog   183 RKESSSQVPSDISSPVGAAWTLNSQPPKTNSHQPRSISVSAIPFSESSSQGPYIYAENLQDPFSS 247

  Fly   155 VEVISGVRL------------CDALMKALKLR--------------QLTPDMCEVSTTHSGRHII 193
            ...||.:.|            ...|.:|:||:              ||.|:...:..:.|
 Frog   248 STPISRLTLRTPHGFTITPPTTPQLKRAIKLKPPRTPPPPGRKVFQQLLPNFSTLKRSKS----- 307

  Fly   194 PWHTDIGTLHVEEIFVRLLDKFP-----------------IRTHIKHQIIRKTFFSLVFCEGCRR 241
                     |..::..| :|:.|                 |...:.|:...|::.|.: |..|::
 Frog   308 ---------HESQLGNR-IDEVPSLKFDLPQGSPQMVRRDIGLSVTHRFSTKSWLSQM-CHVCQK 361

  Fly   242 LLFTGFYCSQCNFRFHQRCANRVPMLC-------------QPFPMDSYYQLLLAENPDNGVGFPG 293
            .:..|..|..|..:.|.:|....|. |             :..|.|...|:.....|..|. .|.
 Frog   362 SMMFGVKCKHCKLKCHNKCTKDAPS-CRISFLPIAKIRRTESVPSDINNQVDRPAEPHFGT-LPK 424

  Fly   294 RGTAVRFNMSSR---SRSRRCSSSGSSSSSKPPSSSSGNHRQGRPPRIS----QDDRSNSA---- 347
            ..|....:.:..   |.|...|::.|:.||..|..||.......||..|    :|.|.|..
 Frog   425 ALTKKEHSPAINHLDSSSNPSSTTSSTPSSPAPFQSSNPSSAITPPNPSPIGPRDSRFNFPAAYY 489

  Fly   348 ---------PNVCINNIRSVTSEVQRSLIMQARPPLPHPCTD------------HSNSTQASPTS 391
                     |.|.:....|..||...:...:|...     ||            .:|.::.....
 Frog   490 IQHRQQFIFPEVSVTAQASHVSETSENSSAEAEME-----TDVAEEQEAEVEEQDANKSEPEYDD 549

  Fly   392 TLKHNRPRARSADESNKNLLLRDAKSSE---ENWNILAEEILIGPRIGSGSFGTVYRAHWHGPVA 453
            ......|.:|....:.:.:::|.|..:.   :.|:|..|:|.:|..||.|.:|.|:|..|||.||
 Frog   550 DELDELPNSRYTSGTFRGMIIRKASQTSVYLQEWDIPFEQIELGELIGQGRWGKVFRGKWHGEVA 614

  Fly   454 VKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLYKHVHVSE 517
            ::.|.:...:...|:.||.||...::|||.|::|||| |:..|.|||:|.:|:|.:||..|...:
 Frog   615 IRLLEIDGNNQDHLKLFKKEVMNYRQTRHENVVLFMGACMHPPHLAIITSFCKGRTLYSFVRDPK 679

  Fly   518 TKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQA 582
            |...:|....|.:::.:||.|||||.|:|:||||.|:| :|:..|.|.||||..........::.
 Frog   680 TSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVF-YENGKVVITDFGLFGISGVVQEGRRE 743

  Fly   583 NQPTGSILW---MAPEVIRM------QELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQIL 638
            |:...|..|   :|||::|.      ::..|:|..:|:||||.:.|||.|...|... ...:.::
 Frog   744 NELKLSHDWLCYLAPEIVREMTPGKGEDTLPFSKAADIYAFGTIWYELQARDWPLKR-QAAEALI 807

  Fly   639 FMVGRGLLRPDMSQVRS--DAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIHRSAS 701
            :.:|.|   ..|.||.|  ...:.:..:...|..:...:||.|..|::|||.    |||::|..|
 Frog   808 WQIGSG---EGMKQVLSTISLGKEVTEILAACWAFDVNERPSFTLLMDMLEK----LPKLNRRLS 865

  Fly   702 EP 703
            .|
 Frog   866 HP 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Raf	NP_525047.1	RBD_RAF	142..212	CDD:340514	15/111 (14%)
		C1_Raf	221..269	CDD:410361	12/60 (20%)
		STKc_Raf	435..687	CDD:270964	92/263 (35%)
ksr1	XP_031751648.1	SAM_KSR1	98..163	CDD:463916	19/107 (18%)
		C1_KSR1	342..388	CDD:410422	11/47 (23%)
		STKc_KSR1	589..867	CDD:271054	101/286 (35%)