DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2854 and CG13295

DIOPT Version :9

Sequence 1:	NP_569999.1	Gene:	CG2854 / 31219	FlyBaseID:	FBgn0040391	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_648021.1	Gene:	CG13295 / 38692	FlyBaseID:	FBgn0035674	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	183/512 - (35%)
Similarity:	283/512 - (55%)	Gaps:	64/512 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RFLTPRRIVDYCRRLLSTDLVTALRPFYQAIRTDGLAHNPAEKRVNEESLRLLCSHLESL----- 64
            :.:|.||.....||.|:.||.|||||||.|:..|..|.:|.::..||.||:||..|||:|
  Fly    11 KLVTSRRHFLLLRRSLNQDLTTALRPFYFAVHPDFFAQHPEQRNTNENSLKLLSEHLEALYERRQ 75

  Fly    65 -TGPSASCLPPDGHLEFYIPSGSDESGSRVVSRLVRVQVD-RSLLDPRAVICQILRSCKLLPKEK 127
             :|.:..       |:||:.:.|| :..|...:|::::.| :|..||:..|..:|.||.|
  Fly    76 RSGDTQV-------LKFYVRTSSD-ADKRDSFKLIQIRTDWQSTRDPKTFIQGLLESCNL----- 127

  Fly   128 EQEQMKRGQEMEKELGKVLRKEPVRERVRPPQ------------------APVQKNLSALRELFK 174
                       ..|..|.::.:|     .||:                  |..:..|...|
  Fly   128 -----------STEYVKNIKAQP-----EPPKTSGLDFKPSHDYHYDMEFAEFETQLKNER---- 172

  Fly   175 DAKREHSLEIWMRQ--ALARSQASEVATLRGKIEGIEAALVQLLGIRGTRYDCGCNMERYHNCLS 237
             |.:...|..|:.:  ..|:.::.|.|.|:.:|:.::..||:.|.::..||:||.|:|.|..||.
  Fly   173 -ASKRPVLTTWLEENAGTAKQRSKETADLQAEIDKLKKMLVEKLELQDARYECGWNIEHYRGCLK 236

  Fly   238 ILKGLSEDPKVAGQLGALRNRFVVFAPYTGISLEGDVMLFSGDSPSGWLAFLSEMRLHEEQLRLV 302
            .|:.||....:  ::.:|:.|.|||||:|||||||.||||:||..|.|:.|:..:..|:..|::|
  Fly   237 TLERLSNTHLL--EMASLKGRIVVFAPFTGISLEGHVMLFTGDVLSTWIDFIKNIPHHDAYLKVV 299

  Fly   303 PLYEKALSAVLLGIRIERRRVPEPGCEARAYAGSLRRVIRAVSEHLRLEDSVQELPASLQDHHLA 367
            |:||:.||.|||.|:|.||:. .|..:|..||..|.:|..::|::|..:....|.|.:|::..:.
  Fly   300 PVYERTLSQVLLNIQIGRRKF-MPKQQASGYASYLMKVTTSLSDYLGKQKYPPEWPKTLKEFTIV 363

  Fly   368 IVPDSDIPKVSQTGLFLAPASCSGPDLVEFICRNLDVASGRFSRYRRDIQVERQLWRQCQEELGL 432
            :..::....||.||.|:.||:|.|..||:||..||::|..|..:|.:|..:|::|...|.::|.|
  Fly   364 VESEAGPLMVSPTGQFITPATCPGSILVDFISVNLELARERMKKYAQDKHIEQELMDSCIKQLQL 428

  Fly   433 QRLSKDDSVTPDKMVMAIRHLLQSGVKSCRGLSLHITNYWSVPTDGIVCIPWDFMSR 489
            |.|:|||::|||||:.::|.|.|..:|..:|..||||:|:||.|||:|||||||:.|
  Fly   429 QSLTKDDAITPDKMITSLRDLYQLQLKELQGCKLHITHYYSVLTDGVVCIPWDFLQR 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2854	NP_569999.1	DUF4460	15..117	CDD:291359	39/108 (36%)
CG2854	NP_569999.1	DUF4461	181..486	CDD:291360	125/306 (41%)
CG13295	NP_648021.1	DUF4460	23..122	CDD:291359	39/106 (37%)
CG13295	NP_648021.1	DUF4461	179..482	CDD:291360	125/305 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454994
Domainoid	1	1.000	141	1.000	Domainoid score	I4664
eggNOG	1	0.900	-	-		E1_28KZH
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I3595
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47934
OrthoDB	1	1.010	-	-		D532678at33208
OrthoFinder	1	1.000	-	-		FOG0006588
OrthoInspector	1	1.000	-	-		otm24379
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR31596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4830
	11	10.910