DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2854 and Tcaim

DIOPT Version :9

Sequence 1:	NP_569999.1	Gene:	CG2854 / 31219	FlyBaseID:	FBgn0040391	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_006244254.1	Gene:	Tcaim / 363169	RGDID:	1560717	Length:	507	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	132/509 - (25%)
Similarity:	217/509 - (42%)	Gaps:	70/509 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 YCRRLLSTDLVTALRPFYQAIRTDGLAHNPAEKRVNEESLRLLCSHLESLTGPSASCLPPDGHLE 79
            |.|.|...:.:.||||||.|:..|....:|.|:.|||.||:.|..:||:|..|....|.|. .|.
  Rat    33 YSRALSGAEAINALRPFYFAVHPDFFGQHPREREVNENSLKRLSVYLENLQKPGFKSLKPT-QLT 96

  Fly    80 FYI---PSGSDESGSRVVS----RLVRVQVDRSLLDPRAVICQILRSCKLLPKEKEQEQMKRGQE 137
            |||   .:.:...|...||    |.||..:..|  |..:.:..||.||. ||.|..|
  Rat    97 FYIREKTAQNSSEGQEPVSTTGFRAVRFTLHSS--DLLSTVLYILNSCS-LPVEHVQ-------- 150

  Fly   138 MEKELGKVLRKEPVRERVRPPQAPVQKNLSALREL-FKD--------AKREHSLEIWM----RQA 189
               .|...:..:|::|....|..|::.:.|..... |||        ::.|.:|..|:    :.|
  Rat   151 ---SLNTNVHSQPLKEATGMPDRPIKWHRSYYSFTGFKDPDEDLEHVSRVETTLTSWLGSNGKGA 212

  Fly   190 LARSQASEVATLRGKIEGIEAALVQLLGIRGTRYDCGCNMERYHNCLSILKGLSEDPKVAGQ-LG 253
            :.:.:.|  ..||.:::.::..|.:||.:...|:..|..:.  |.| |.|..||   ::|.| |.
  Rat   213 VKKLKNS--LPLRKELDRLKNELSELLQLSDIRWQRGWGVA--HRC-SQLHSLS---RLAQQNLE 269

  Fly   254 ALRNR---FVVFAPYTGISLEGDVMLFSGDSPSGWLAFLSEMRLHEEQLRLVPLYEKALSAVLLG 315
            .|:|.   .:||...:|:|..|.|||.:.|....|......:..:.:..|.:...|..:|.:|.|
  Rat   270 PLQNAKGCTIVFTDRSGMSALGHVMLGTMDVHHHWTRLFESLPNYFDLQRRMSALEDQISHLLGG 334

  Fly   316 IRIERRRVPEPGCEARAYAGSLRRVIRAVSEHLRLEDS---------VQELPASLQDHHLAIVPD 371
            |::             .|...|:..: .:.|:..|.|:         ....|.||....:.:..|
  Rat   335 IQV-------------VYIEELQPAL-TLDEYYSLLDTFYNQLQRSRAPPRPQSLSGLQMILSSD 385

  Fly   372 SDIPKVSQTGLFLAPASCSGPDLVEFICRNLDVASGRFSRYRRDIQVERQLWRQCQEELGLQRLS 436
            ...|.:.:.|.|..||......|..|:......|.....|..:...:|.:|.:....:..|::|.
  Rat   386 RYAPSLHELGHFNIPALSDPASLQSFMRTKAQQARENMRRREKLKVIENELIQASTRKFSLEKLY 450

  Fly   437 KDDSVTPDKMVMAIRHLLQSGVKSCRGLSLHITNYWSVPTDGIVCIPWDFMSRE 490
            |:.|::..:||...:.||:..:....|:.|.:::::||..||.:||||::...|
  Rat   451 KEPSISSRQMVDCCKRLLEQSLPYLHGMHLCVSHFYSVMQDGDLCIPWNWKKGE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2854	NP_569999.1	DUF4460	15..117	CDD:291359	37/108 (34%)
CG2854	NP_569999.1	DUF4461	181..486	CDD:291360	76/321 (24%)
Tcaim	XP_006244254.1	DUF4460	33..138	CDD:405388	37/107 (35%)
Tcaim	XP_006244254.1	DUF4461	200..500	CDD:405389	76/321 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344535
Domainoid	1	1.000	145	1.000	Domainoid score	I4461
eggNOG	1	0.900	-	-		E1_28KZH
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	211	1.000	Inparanoid score	I3574
OMA	1	1.010	-	-		QHG47934
OrthoDB	1	1.010	-	-		D532678at33208
OrthoFinder	1	1.000	-	-		FOG0006588
OrthoInspector	1	1.000	-	-		otm44378
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR31596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4830
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870