Protein Alignment CG2854 and TCAIM

DIOPT Version :10

• Sequence 1: NP_569999.1
• Gene: CG2854 / 31219
• FlyBaseID: FBgn0040391
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_776187.2
• Gene: TCAIM / 285343
• HGNCID: 25241
• Length: 496
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 129/512 - (25%)
• Similarity: 217/512 - (42%)
• Gaps: 77/512 - (15%)

  Fly    15 YCRRLLSTDLVTALRPFYQAIRTDGLAHNPAEKRVNEESLRLLCSHLESLTGPSASCLPPDGHLE 79
            :.|.|...:.|.||||||.|:..|....:|.|:.:||.||:.|..:||:|..|....|.|. .|.
Human    23 FSRALSGAEAVNALRPFYFAVHPDFFGQHPVEREINENSLKRLSVYLENLQKPGFKSLKPT-QLT 86

  Fly    80 FYI----PSGSD------ESGSRVVSRLVRVQVDRSLLDPRAVICQILRSCKLLPKEKEQEQMKR 134
            ||:    .|.||      .||.|.|...:..   |.||   :.:..||.||.|
Human    87 FYVRETDQSSSDGQEPFSTSGFRAVKFTLHT---RDLL---STVLYILNSCSL------------ 133

  Fly   135 GQEMEKELGKVLRKEPVRERVRPPQAPVQKNLSALREL-FKD--------AKREHSLEIWM---- 186
            ..|..:.|...:..:|::|..|.|..|::.:.|..... |||        ::.|.:|..|:
Human   134 SVEHIQSLNTNMHTQPLKEAKRMPDRPIKWDKSYYSFTGFKDPDEDLEQVSRVETTLTSWLDNNG 198

  Fly   187 RQALARSQASEVATLRGKIEGIEAALVQLLGIRGTRYDCGCNMERYHNCLSILKGLSEDPKVAGQ 251
            :.|:.:.:.|  ..||.:::.::..|...|.:...|:.....:.  |.| |.|..||   ::|.|
Human   199 KSAVKKLKNS--LPLRKELDRLKDELSHQLQLSDIRWQRSWGIA--HRC-SQLHSLS---RLAQQ 255

  Fly   252 ----LGALRNRFVVFAPYTGISLEGDVMLFSGDSPSGWLAFLSEMRLHEEQLRLVPLYEKALSAV 312
                |...:...::|...:|:|..|.|||.:.|....|......:..:.:..|.:.:.|..:|.:
Human   256 NLETLKKAKGCTIIFTDRSGMSAVGHVMLGTMDVHHHWTKLFERLPSYFDLQRRLMILEDQISYL 320

  Fly   313 LLGIRIERRRVPEPGCEARAYAGSLRRVIRAVSEHLRLED---------SVQELPASLQDHHLAI 368
            |.||::             .|...|:.|: .:.|:..|.|         .:...|.||:...:.:
Human   321 LGGIQV-------------VYIEELQPVL-TLEEYYSLLDVFYNRLLKSRILFHPRSLRGLQMIL 371

  Fly   369 VPDSDIPKVSQTGLFLAPASCSGPDLVEFICRNLDVASGRFSRYRRDIQVERQLWRQCQEELGLQ 433
            ..|...|.:.:.|.|..|..|...:|..||......|.....|......:|.:|.:...::..|:
Human   372 NSDRYAPSLHELGHFNIPTLCDPANLQWFILTKAQQARENMKRKEELKVIENELIQASTKKFSLE 436

  Fly   434 RLSKDDSVTPDKMVMAIRHLLQSGVKSCRGLSLHITNYWSVPTDGIVCIPWDFMSRE 490
            :|.|:.|::..:||...:.||:..:....|:.|.|::::||..||.:||||::.:.|
Human   437 KLYKEPSISSIQMVDCCKRLLEQSLPYLHGMHLCISHFYSVMQDGDLCIPWNWKNGE 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2854	NP_569999.1	DUF4460	15..122	CDD:464262	41/116 (35%)
		DUF4461	181..486	CDD:464263	74/321 (23%)
TCAIM	NP_776187.2	DUF4460	24..133	CDD:464262	41/115 (36%)
		DUF4461	189..489	CDD:464263	74/321 (23%)