DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and hscC

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_415183.1	Gene:	hscC / 945218	ECOCYCID:	G6357	Length:	556	Species:	Escherichia coli

Alignment Length:	568	Identity:	129/568 - (22%)
Similarity:	230/568 - (40%)	Gaps:	136/568 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 MSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYGYL 87
            :.:|||:....:.|...|. .::..|:..:..||:|::.                 |.|:..
E. coli     8 IGIDLGTTNSLIAVWKDGA-AQLIPNKFGEYLTPSIISM-----------------DENNHI--- 51

  Fly    88 LDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKS---------DTDEFSVEELVAQLLVK 143
              |:||    |.|.   :|      ...|::...:|:::         .:|.|:..||.:.:|..
E. coli    52 --LVGK----PAVS---RR------TSHPDKTAALFKRAMGSNTNWRLGSDTFNAPELSSLVLRS 101

  Fly   144 AKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEI 208
            .|:.|:|.:|:||.:.|::||.||...:|:....||:||.|..::|||:..|.|:.||: |..:.
E. coli   102 LKEDAEEFLQRPIKDVVISVPAYFSDEQRKHTRLAAELAGLNAVRLINEPTAAAMAYGL-HTQQN 165

  Fly   209 NETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQ 273
            ..:    |.:|:|.......|:.|          ..||::|.....|..|||.:....|.|
E. coli   166 TRS----LVFDLGGGTFDVTVLEY----------ATPVIEVHASAGDNFLGGEDFTHMLVD---- 212

  Fly   274 EFNALKKTKTDVTT-SPRALAKLFK--EAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTR--EK 333
              ..||:.....|| :...||.|:.  ||.:..|....:..:..|.|            ||  |.
E. coli   213 --EVLKRADVARTTLNESELAALYACVEAAKCSNQSPLHIRWQYQEE------------TRECEF 263

  Fly   334 LEQLCEDLW----PRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNL 394
            .|...||||    .|...|:|:||..:.|....|:.::|.||.:::|.||.....:..:...::.
E. coli   264 YENELEDLWLPLLNRLRVPIEQALRDARLKPSQIDSLVLVGGASQMPLVQRIAVRLFGKLPYQSY 328

  Fly   395 NADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKR---------A 450
            :......:||..:||.......:::.::.|...:.|.|...|....|.....::|         .
E. coli   329 DPSTIVALGAAIQAACRLRSEDIEEVILTDICPYSLGVEVNRQGVSGIFSPIIERNTTVPVSRVE 393

  Fly   451 LFALMNPYPQKKVITFNKH------------TDDFEFYVN----YADLD-RYSKE-----EIAAL 493
            .::.|  :|::..||.|.:            .:.|:..:.    |..:| |:|.:     |:..|
E. coli   394 TYSTM--HPEQDSITVNVYQGENHKVKNNILVESFDVPLKKTGAYQSIDIRFSYDINGLLEVDVL 456

  Fly   494 ---GS-----LNVTKVQL--KQVKE------LLEKSKKELVDNKGIKA 525
               ||     :|.:.|.|  :|::|      .|:...::::.|:..||
E. coli   457 LEDGSVKSRVINHSPVTLSAQQIEESRTRLSALKIYPRDMLINRTFKA 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	129/568 (23%)
		HYOU1-like_NBD	23..409	CDD:212672	98/403 (24%)
		TAF4	<572..>627	CDD:296797
hscC	NP_415183.1	HscC_like_NBD	8..343	CDD:212677	98/403 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	1	0.900