DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and SSE1

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_015219.1	Gene:	SSE1 / 855998	SGDID:	S000006027	Length:	693	Species:	Saccharomyces cerevisiae

Alignment Length:	791	Identity:	204/791 - (25%)
Similarity:	349/791 - (44%)	Gaps:	122/791 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGE---DAQTIGIKDPNSAYGY 86
            :|||:. ..|..|:....::|.:|..|.|.||:::.|....|.:||   :.||..||   :....
Yeast     7 LDLGNN-NSVLAVARNRGIDIVVNEVSNRSTPSVVGFGPKNRYLGETGKNKQTSNIK---NTVAN 67

  Fly    87 LLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFR-KSDTDEFSVEELVAQLLVKAKQFAQE 150
            |..::|....:|..:...|.|....:..|.::.....| ..:...||..:|.|..:.|.|...::
Yeast    68 LKRIIGLDYHHPDFEQESKHFTSKLVELDDKKTGAEVRFAGEKHVFSATQLAAMFIDKVKDTVKQ 132

  Fly   151 SVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFH----RGEINET 211
            ..:..||:..:.||.::.:.:|..:..||::|.|..::::||..|..::||:|.    .||  |.
Yeast   133 DTKANITDVCIAVPPWYTEEQRYNIADAARIAGLNPVRIVNDVTAAGVSYGIFKTDLPEGE--EK 195

  Fly   212 AQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFN 276
            .:...|.|:|....:.:::::   |..|       ::|||...|:..||.:..|.:.::.|.||.
Yeast   196 PRIVAFVDIGHSSYTCSIMAF---KKGQ-------LKVLGTACDKHFGGRDFDLAITEHFADEFK 250

  Fly   277 ALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDL 341
            .  |.|.|:..:|:|..::...|.:||.||||||.....:|:::.|:|....::||:||:|.:.|
Yeast   251 T--KYKIDIRENPKAYNRILTAAEKLKKVLSANTNAPFSVESVMNDVDVSSQLSREELEELVKPL 313

  Fly   342 WPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESATMGAVY 406
            ..|.|:|:.:|||.:.||.:.::.|.:.||.||:|.::::|.....:.|...||.||:...||.:
Yeast   314 LERVTEPVTKALAQAKLSAEEVDFVEIIGGTTRIPTLKQSISEAFGKPLSTTLNQDEAIAKGAAF 378

  Fly   407 KAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVK----RALFALMNPYPQKKVITFN 467
            ..|..|...:|:.|..:|  :.|..||:..|       |||:    ..:|...:.:|..|:||.|
Yeast   379 ICAIHSPTLRVRPFKFED--IHPYSVSYSWD-------KQVEDEDHMEVFPAGSSFPSTKLITLN 434

  Fly   468 KHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKGIKAYFYLDDS 532
            : |.||....:|.|:.:........:.:..:|.|||.:.:           |:..:|.....|.|
Yeast   435 R-TGDFSMAASYTDITQLPPNTPEQIANWEITGVQLPEGQ-----------DSVPVKLKLRCDPS 487

  Fly   533 GIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPSKSE 597
            |:                             .|:.:.:|.|..|.             |||....
Yeast   488 GL-----------------------------HTIEEAYTIEDIEV-------------EEPIPLP 510

  Fly   598 DNEKAKEEDASKEQKSEEST--KQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAK 660
            ::   ..|||.:|.|....|  |.|......|..|...|.....|.:.:.:      |.|:.||
Yeast   511 ED---APEDAEQEFKKVTKTVKKDDLTIVAHTFGLDAKKLNELIEKENEML------AQDKLVA- 565

  Fly   661 LAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDLE 725
                 :.|:::       |.||.:|..::.||:|| ||..|:..||.||....:...||||::..
Yeast   566 -----ETEDRK-------NTLEEYIYTLRGKLEEE-YAPFASDAEKTKLQGMLNKAEEWLYDEGF 617

  Fly   726 DPKAEIYEEKLAQLKKLSNVFLARHW-EHEERPEAIKA---LKGMIDGAEKFLVTGRNLTKDTNP 786
            |.....|..|..:|..|.|:...|:. :.||:.:||::   ...|...|||.....:...:....
Yeast   618 DSIKAKYIAKYEELASLGNIIRGRYLAKEEEKKQAIRSKQEASQMAAMAEKLAAQRKAEAEKKEE 682

  Fly   787 EKDVFTQVEID 797
            :||....|::|
Yeast   683 KKDTEGDVDMD 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	157/613 (26%)
		HYOU1-like_NBD	23..409	CDD:212672	110/391 (28%)
		TAF4	<572..>627	CDD:296797	13/56 (23%)
SSE1	NP_015219.1	HSP70	4..644	CDD:394970	192/740 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810