DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and SSC1

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_012579.1	Gene:	SSC1 / 853503	SGDID:	S000003806	Length:	654	Species:	Saccharomyces cerevisiae

Alignment Length:	759	Identity:	190/759 - (25%)
Similarity:	324/759 - (42%)	Gaps:	168/759 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KLVLLLSALLAGIALS--------QGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAI 58
            |.:|..|:|.:...::        || :|:.:|||:....|.::...|| :|..|.|..|.||::
Yeast     5 KNILNRSSLSSSFRIATRLQSTKVQG-SVIGIDLGTTNSAVAIMEGKVP-KIIENAEGSRTTPSV 67

  Fly    59 LAF-RDGTRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVV 122
            :|| ::|.|.:|..|:...:.:|.:.......|:|:..::..|....|:.| |.||.....:..|
Yeast    68 VAFTKEGERLVGIPAKRQAVVNPENTLFATKRLIGRRFEDAEVQRDIKQVP-YKIVKHSNGDAWV 131

  Fly   123 FRKSDTDEFSVEELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVL 187
            ..:..|  :|..::...:|.|.|:.|:..:.:|:...|:|||.||..::|:|...|.|:..|.||
Yeast   132 EARGQT--YSPAQIGGFVLNKMKETAEAYLGKPVKNAVVTVPAYFNDSQRQATKDAGQIVGLNVL 194

  Fly   188 QLINDYAAVALNYGVFHRGEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGV 252
            :::|:..|.||.||:    |.:::....:| |:|......:::...          |.|.:|...
Yeast   195 RVVNEPTAAALAYGL----EKSDSKVVAVF-DLGGGTFDISILDID----------NGVFEVKST 244

  Fly   253 GYDRTLGGLEIQLRLRDYLAQEFNALKKTKT--DVTTSPRALAKLFKEAGRLKNVLSA------N 309
            ..|..|||.:..:    ||.:|..:..||:|  |:.....|:.::.:.|.:.|..||:      |
Yeast   245 NGDTHLGGEDFDI----YLLREIVSRFKTETGIDLENDRMAIQRIREAAEKAKIELSSTVSTEIN 305

  Fly   310 TEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTR 374
            ..|.....:..:.|:.|.  :|.:.|.|...|..|...|:::||..:.||...|::|:|.||.:|
Yeast   306 LPFITADASGPKHINMKF--SRAQFETLTAPLVKRTVDPVKKALKDAGLSTSDISEVLLVGGMSR 368

  Fly   375 VPRVQETIKAVIKQELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPG 439
            :|:|.||:|::..::..|.:|.||:..:||..:.|.||.  :|...::.|.|  ||.:..|...|
Yeast   369 MPKVVETVKSLFGKDPSKAVNPDEAVAIGAAVQGAVLSG--EVTDVLLLDVT--PLSLGIETLGG 429

  Fly   440 DGAAVKQVKRALFALMNP----YPQKKVITFNKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTK 500
                       :|..:.|    .|.||...|:                      .||.|..:|..
Yeast   430 -----------VFTRLIPRNTTIPTKKSQIFS----------------------TAAAGQTSVEI 461

  Fly   501 VQLKQVKELLEKSKKELVDN----------KG---IKAYFYLDDSGIFRCTGVEYVYEKQKPEDD 552
            ...:..:||:..:|  |:.|          ||   |:..|.:|..||...:.          .|.
Yeast   462 RVFQGERELVRDNK--LIGNFTLAGIPPAPKGVPQIEVTFDIDADGIINVSA----------RDK 514

  Fly   553 A-DEDSTLSKFGST-LSKLFTKEGEEKKDNSEQEEAANAGEEPSKSEDNEKAKEEDASKEQKSEE 615
            | ::||:::..||: ||:            :|.|:..|         |.||.|.:|.:::|..|.
Yeast   515 ATNKDSSITVAGSSGLSE------------NEIEQMVN---------DAEKFKSQDEARKQAIET 558

  Fly   616 STKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNA 680
            :.|.|..|.:      |..|...:|.:                     ::|||.|:||  ....:
Yeast   559 ANKADQLAND------TENSLKEFEGK---------------------VDKAEAQKVR--DQITS 594

  Fly   681 LEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDL 724
            |:..:..||.  .||     ..|||.:....|..|....|:|.|
Yeast   595 LKELVARVQG--GEE-----VNAEELKTKTEELQTSSMKLFEQL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	162/630 (26%)
		HYOU1-like_NBD	23..409	CDD:212672	108/394 (27%)
		TAF4	<572..>627	CDD:296797	13/54 (24%)
SSC1	NP_012579.1	dnaK	30..633	CDD:234715	185/734 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900