DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and KAR2

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_012500.3	Gene:	KAR2 / 853418	SGDID:	S000003571	Length:	682	Species:	Saccharomyces cerevisiae

Alignment Length:	770	Identity:	194/770 - (25%)
Similarity:	321/770 - (41%)	Gaps:	161/770 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KLVLLLSALLAGI---------------ALSQGA-------AVMSVDLGSEWMKVGVVSPGVPME 44
            ||::.||.:|..:               .|.:||       .|:.:|||:.:..|.|:..| ..|
Yeast    10 KLLVPLSVVLYALFVVILPLQNSFHSSNVLVRGADDVENYGTVIGIDLGTTYSCVAVMKNG-KTE 73

  Fly    45 IALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPY 109
            |..|.:..|.||:.:||.|..|.||:.|:.....:|.:....:..|:|...::..|....|..|
Yeast    74 ILANEQGNRITPSYVAFTDDERLIGDAAKNQVAANPQNTIFDIKRLIGLKYNDRSVQKDIKHLP- 137

  Fly   110 YNIVGDPERNTV-VFRKSDTDEFSVEELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAERE 173
            :|:|....:..| |..|.:...|:.||:...:|.|.||.|::.:...:|..|:|||.||..|:|:
Yeast   138 FNVVNKDGKPAVEVSVKGEKKVFTPEEISGMILGKMKQIAEDYLGTKVTHAVVTVPAYFNDAQRQ 202

  Fly   174 ALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINETAQYFLFYDMGAYKTSAAVVSYQLVKDK 238
            |...|..:|.|.||:::|:..|.|:.||:    :.::.....:.||:|......:::|.:
Yeast   203 ATKDAGTIAGLNVLRIVNEPTAAAIAYGL----DKSDKEHQIIVYDLGGGTFDVSLLSIE----- 258

  Fly   239 QTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALKKTKTDVTTSPRALAKLFKEAGRLK 303
                 |.|.:|.....|..|||.:...::...|.:.|.  ||...||:.:.:|||||.:||.:.|
Yeast   259 -----NGVFEVQATSGDTHLGGEDFDYKIVRQLIKAFK--KKHGIDVSDNNKALAKLKREAEKAK 316

  Fly   304 NVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVIL 368
            ..||:......:|::.::.||....:||.|.|:|..||:.:..||:|:.|..|.|....::.::|
Yeast   317 RALSSQMSTRIEIDSFVDGIDLSETLTRAKFEELNLDLFKKTLKPVEKVLQDSGLEKKDVDDIVL 381

  Fly   369 FGGGTRVPRVQETIKAVIK-QELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQV 432
            .||.||:|:||:.:::... ::..|.:|.||:...||..:|..||....|:..|:.|.....|.:
Yeast   382 VGGSTRIPKVQQLLESYFDGKKASKGINPDEAVAYGAAVQAGVLSGEEGVEDIVLLDVNALTLGI 446

  Fly   433 SFERDPGDGAAVKQVKRALFALMNPYPQKKVITFNKHTDDF-EFYVNYADLDRYSKEEIAALGSL 496
                :...|.....:||     ....|.||...|:...|:. ...:...:.:|...::...||..
Yeast   447 ----ETTGGVMTPLIKR-----NTAIPTKKSQIFSTAVDNQPTVMIKVYEGERAMSKDNNLLGKF 502

  Fly   497 NVTKVQLKQVKELLEKSKKELVDNKG---IKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDST 558
            .:|.:....               :|   |:..|.||.:||.:.:              |.:..|
Yeast   503 ELTGIPPAP---------------RGVPQIEVTFALDANGILKVS--------------ATDKGT 538

  Fly   559 LSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEA 623
                |.:.|...|.:    |....|||.....||.      ||...||||
Yeast   539 ----GKSESITITND----KGRLTQEEIDRMVEEA------EKFASEDAS--------------- 574

  Fly   624 KNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEV 688
                ||                             ||:.:.||.|.....|::..|.      ::
Yeast   575 ----IK-----------------------------AKVESRNKLENYAHSLKNQVNG------DL 600

  Fly   689 QQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDLEDPKAEIYEEKLAQLKKLS 743
            .:||:|         |:||.||...:.:.|||.::.|...||.::||...|.|::
Yeast   601 GEKLEE---------EDKETLLDAANDVLEWLDDNFETAIAEDFDEKFESLSKVA 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	159/608 (26%)
		HYOU1-like_NBD	23..409	CDD:212672	115/387 (30%)
		TAF4	<572..>627	CDD:296797	12/54 (22%)
KAR2	NP_012500.3	HSP70	52..654	CDD:394970	186/728 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810