DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and HSP91

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_178111.1	Gene:	HSP91 / 844333	AraportID:	AT1G79930	Length:	831	Species:	Arabidopsis thaliana

Alignment Length:	924	Identity:	232/924 - (25%)
Similarity:	411/924 - (44%)	Gaps:	122/924 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVV-SPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAY 84
            :|:..|.|:|...|.|. ..|:  ::.||.||.|:||||:.|.|..|.||.......:.:|.::.
plant     2 SVVGFDFGNENCLVAVARQRGI--DVVLNDESNRETPAIVCFGDKQRFIGTAGAASTMMNPKNSI 64

  Fly    85 GYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRK--SDTDEFSVEELVAQLLVKAKQF 147
            ..:..|:|:...:|.:....|..| :::...|:...::...  .:...|:..:::..:|...|..
plant    65 SQIKRLIGRQFSDPELQRDIKSLP-FSVTEGPDGYPLIHANYLGEKRAFTPTQVMGMMLSNLKGI 128

  Fly   148 AQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINETA 212
            |::::...:.:|.:.:|.||...:|.|:|.||.:|.|..|:||::..|.||.||:: :.::.|:.
plant   129 AEKNLNTAVVDCCIGIPVYFTDLQRRAVLDAATIAGLHPLRLIHETTATALAYGIY-KTDLPESD 192

  Fly   213 QY-FLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFN 276
            |. ..|.|:|.......:..:   |..|       :::|...:||:|||.:....|.::.|.:|.
plant   193 QLNVAFIDIGHASMQVCIAGF---KKGQ-------LKILSHAFDRSLGGRDFDEVLFNHFAAKFK 247

  Fly   277 ALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDL 341
              .:.|.||:.:.:|..:|.....:||.|||||......||.|:::.|.:..:.||:.|::...:
plant   248 --DEYKIDVSQNAKASLRLRATCEKLKKVLSANPLAPLNIECLMDEKDVRGVIKREEFEEISIPI 310

  Fly   342 WPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESATMGAVY 406
            ..|..:|||:||:.:.|:::.::.|.:.|.|:|||.:.:.:.....:|..:.:||.|..:.|...
plant   311 LERVKRPLEKALSDAGLTVEDVHMVEVIGSGSRVPAMIKILTEFFGKEPRRTMNASECVSRGCAL 375

  Fly   407 KAADLSAGFKVKKFVVKDATLFPLQVSF-----ERDPGDGAAVKQVKRALFALMNPYPQKKVITF 466
            :.|.||..|||::|.|.::  ||..:|.     ..:..:|.|..|....:|...||.|..|.:||
plant   376 QCAILSPTFKVREFQVHES--FPFSISLAWKGAASEAQNGGAENQQSTIVFPKGNPIPSVKALTF 438

  Fly   467 NKHTDDFEFYVNYADL-DRYSKEEIA--ALGSLNVTKVQLKQVKELLEKSKKELVDNKGIKAYFY 528
            .: :..|...|.|:|: |..:..:|:  .:|....:|.         |::|.::.....:.....
plant   439 YR-SGTFSVDVQYSDVNDLQAPPKISTYTIGPFQSSKG---------ERAKLKVKVRLNLHGIVS 493

  Fly   529 LDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGE-- 591
            ::.:.:.....||....|:..|:....||                     |.:..|.|..:|:
plant   494 VESATLLEEEEVEVPVTKEHSEETTKMDS---------------------DKASAEAAPASGDCD 537

  Fly   592 -EPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYD 655
             ....::|...|...|....:.:|:..:.:|::|.|..|....|:.          |||....|
plant   538 VNMQDAKDTSDATGTDNGVPESAEKPVQMETDSKAEAPKKKVKKTN----------VPLSELVY- 591

  Fly   656 QSVAKLAAINKAEEQRVRL----------ESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLL 710
             ...|...:.||.|:...:          :...||:|:::.:::.||.:: |.:..|..|:|..|
plant   592 -GALKTVEVEKAVEKEFEMALQDRVMEETKDRKNAVESYVYDMRNKLSDK-YQEYITDSEREAFL 654

  Fly   711 AECSTLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLV 775
            |....:.:|||||.||....:|..||.:|||:.:....|:.|..||...|..|...|:
plant   655 ANLQEVEDWLYEDGEDETKGVYVAKLEELKKVGDPVEVRYKESLERGSVIDQLGYCIN------- 712

  Fly   776 TGRNLTKDTNPEKDVFTQVEIDTLDKVI---TETNAWLKTETAAQKKLAKNADIRLTVKDITDKM 837
            :.|.....|:|:   |..:|:....||:   .|..|||:.:...|..|.|.|...|...|:..|.
plant   713 SYREAAMSTDPK---FDHIELAEKQKVLNECVEAEAWLRGKQQQQDTLPKYATPALLSADVKSKA 774

  Fly   838 SLLDREVKYLVNKIKIWKPKVKPAAEKEKKKEEEVVASGSGDDTKSEDAEQQQEQATKEEQQEQE 902
            ..||:..:.::.|.   ||..|..|.:.|..|:       .|:.|||          .|:....|
plant   775 EALDKFCRPIMTKP---KPVAKAEAPQAKGGEQ-------ADEGKSE----------PEQPASAE 819

  Fly   903 PVDEITPTPAEEET 916
            |::  |..|||..|
plant   820 PME--TENPAEGST 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	150/617 (24%)
		HYOU1-like_NBD	23..409	CDD:212672	103/389 (26%)
		TAF4	<572..>627	CDD:296797	10/57 (18%)
HSP91	NP_178111.1	HSPA4_like_NDB	2..381	CDD:212670	105/394 (27%)
HSP91	NP_178111.1	PTZ00121	<511..824	CDD:173412	90/378 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810