DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and Hsp70b

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_173055.1	Gene:	Hsp70b / 838174	AraportID:	AT1G16030	Length:	646	Species:	Arabidopsis thaliana

Alignment Length:	756	Identity:	178/756 - (23%)
Similarity:	315/756 - (41%)	Gaps:	173/756 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 MSVDLGSEWMKVGV-VSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYGY 86
            :.:|||:.:..||| ::..|  ||..|.:..|.||:.:||.|..|.||:.|:.....:|.:....
plant     9 IGIDLGTTYSCVGVWMNDRV--EIIPNDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFD 71

  Fly    87 LLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFR-KSDTDEFSVEELVAQLLVKAKQFAQE 150
            ...|:|:...:|.|......:|:..:.|..|:..:|.. |::..:||.||:.:.:|||.|:.|:.
plant    72 AKRLIGRKFSDPSVQSDILHWPFKVVSGPGEKPMIVVSYKNEEKQFSPEEISSMVLVKMKEVAEA 136

  Fly   151 SVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHR----GEINET 211
            .:.:.:...|:|||.||..::|:|...|..::.|.||::||:..|.|:.||:..:    ||.|
plant   137 FLGRTVKNAVVTVPAYFNDSQRQATKDAGAISGLNVLRIINEPTAAAIAYGLDKKGTKAGEKN-- 199

  Fly   212 AQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFN 276
               .|.:|:|......::::.:          ..|.:|.....|..|||.:...||.::...||.
plant   200 ---VLIFDLGGGTFDVSLLTIE----------EGVFEVKATAGDTHLGGEDFDNRLVNHFVAEFR 251

  Fly   277 ALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDL 341
              :|.|.|:..:.|||.:|.....|.|..||:..:...:|::|.|.|||...::|.:.|::..||
plant   252 --RKHKKDIAGNARALRRLRTACERAKRTLSSTAQTTIEIDSLHEGIDFYATISRARFEEMNMDL 314

  Fly   342 WPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATMGAV 405
            :.:...|:|:.|..:.|....::.|:|.||.||:|::|:.::.... :||.|::|.||:...||.
plant   315 FRKCMDPVEKVLKDAKLDKSSVHDVVLVGGSTRIPKIQQLLQDFFNGKELCKSINPDEAVAYGAA 379

  Fly   406 YKAADLS--AGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFNK 468
            .:||.|:  ...||:..::.|..  ||.:..|...|       |...|.......|.||...|:.
plant   380 VQAAILTGEGSEKVQDLLLLDVA--PLSLGLETAGG-------VMTVLIPRNTTVPCKKEQVFST 435

  Fly   469 HTDD-----FEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKG---IKA 525
            :.|:     .:.|    :.:|....:...||:.     :||.:...          .:|   |..
plant   436 YADNQPGVLIQVY----EGERARTRDNNLLGTF-----ELKGIPPA----------PRGVPQINV 481

  Fly   526 YFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAG 590
            .|.:|.:||...:.               ||.|                              ||
plant   482 CFDIDANGILNVSA---------------EDKT------------------------------AG 501

  Fly   591 EEPSKSEDNEK---AKEE------DASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFV 646
            .:...:..|:|   :|||      ||.|.:..:|..|:..|||
plant   502 VKNQITITNDKGRLSKEEIEKMVQDAEKYKAEDEQVKKKVEAK---------------------- 544

  Fly   647 VPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLA 711
                                            |:||.:...::..:.:|..|:..|.|:|:|:..
plant   545 --------------------------------NSLENYAYNMRNTIKDEKLAQKLTQEDKQKIEK 577

  Fly   712 ECSTLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            ......||: |..:..:.:.:|.||.:|:.:.|..:::.::
plant   578 AIDETIEWI-EGNQLAEVDEFEYKLKELEGICNPIISKMYQ 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	160/627 (26%)
		HYOU1-like_NBD	23..409	CDD:212672	114/392 (29%)
		TAF4	<572..>627	CDD:296797	15/63 (24%)
Hsp70b	NP_173055.1	PTZ00009	4..646	CDD:240227	178/756 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810