DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and hspa1b

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001093532.1	Gene:	hspa1b / 798846	ZFINID:	ZDB-GENE-060503-867	Length:	639	Species:	Danio rerio

Alignment Length:	745	Identity:	171/745 - (22%)
Similarity:	325/745 - (43%)	Gaps:	141/745 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LSQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDP 80
            :::|.:: .:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|
Zfish     1 MAKGLSI-GIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNP 63

  Fly    81 NSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAK 145
            |:.......|:|:..|:.:|....|.:|:..|..|.:....|..|.:...|..||:.:.:|||.:
Zfish    64 NNTIFDAKRLIGRKFDDQVVQSDMKLWPFKVISEDGKPKVQVEYKGENKTFYPEEISSMVLVKMR 128

  Fly   146 QFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGV--FHRGEI 208
            :.|:..:...:...|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||:  ..:||.
Zfish   129 EIAEAYLGHRVNNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGRKGER 193

  Fly   209 NETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQ 273
            |     .|.:|:|......::::.:          :.:.:|.....|..|||.:...|:..:..:
Zfish   194 N-----VLIFDLGGGTFDVSILTIE----------DGIFEVKATAGDTHLGGEDFDNRMVKHFVE 243

  Fly   274 EFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLC 338
            ||.  :|.|.|::.:.||:.:|.....|.|..||::::...:|::|.|.|||...:||.:.|:|.
Zfish   244 EFK--RKHKKDISQNKRAVRRLRTACERAKRTLSSSSQASIEIDSLFEGIDFYTSITRARFEELN 306

  Fly   339 EDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATM 402
            .:|:.....|:|:||..:.:....|..::|.||.||:|::|:.::.... ::|.|::|.||:...
Zfish   307 AELFRGTLDPVEKALRDAKMDKSQIQDIVLVGGSTRIPKIQKLLQDFFNGRDLNKSINPDEAVAY 371

  Fly   403 GAVYKAADL--SAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVIT 465
            ||..:||.|  .....|:..::.|..  ||.:..|...|       |..||.......|.|:...
Zfish   372 GAAVQAAILMGDTSENVQDLLLLDVA--PLSLGIETAGG-------VMTALIKRNTTIPTKQTQI 427

  Fly   466 FNKHTDDFE-FYVNYADLDRYSKEEIAALGSLNVTKV--QLKQVKELLEKSKKELVDNKGIKAYF 527
            |:.::|:.. ..:...:.:|...::...||..::|.:  ..:.|.:              |:..|
Zfish   428 FSTYSDNQPGVLIQVFEGERAMTKDNNLLGKFDLTGIPPAPRGVPQ--------------IEVTF 478

  Fly   528 YLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEE 592
            .:|.:||...:              |.:.||               |:|.|
Zfish   479 DIDANGILNVS--------------AADKST---------------GKENK-------------- 500

  Fly   593 PSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQS 657
            .:.:.|..:..:||..:..:..|..|.:.|.:.|.|
Zfish   501 ITITNDKGRLSKEDIERMVQDAEKYKAEDEVQREKI----------------------------- 536

  Fly   658 VAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYE 722
                              :|.||||::...::..:::|:.....:.::|:|::.:|:.:..|| |
Zfish   537 ------------------AAKNALESYAFSMKNTVEDENLRGKISEQDKKKIIDKCTEVVSWL-E 582

  Fly   723 DLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            :.:..:.|.||....:|:.:.|..::|.::
Zfish   583 NNQLAEKEEYEHHQKELESVCNPIISRLYQ 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	150/610 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	112/388 (29%)
		TAF4	<572..>627	CDD:296797	9/54 (17%)
hspa1b	NP_001093532.1	HSP70	1..639	CDD:331774	171/745 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910