Protein Alignment Grp170 and hspa1b

DIOPT Version :10

• Sequence 1: NP_569995.1
• Gene: Grp170 / 31215
• FlyBaseID: FBgn0023529
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_001093532.1
• Gene: hspa1b / 798846
• ZFINID: ZDB-GENE-060503-867
• Length: 639
• Species: Danio rerio
• Alignment Length: 745
• Identity: 171/745 - (22%)
• Similarity: 325/745 - (43%)
• Gaps: 141/745 - (18%)

  Fly    16 LSQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDP 80
            :::|.:: .:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|
Zfish     1 MAKGLSI-GIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNP 63

  Fly    81 NSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAK 145
            |:.......|:|:..|:.:|....|.:|:..|..|.:....|..|.:...|..||:.:.:|||.:
Zfish    64 NNTIFDAKRLIGRKFDDQVVQSDMKLWPFKVISEDGKPKVQVEYKGENKTFYPEEISSMVLVKMR 128

  Fly   146 QFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGV--FHRGEI 208
            :.|:..:...:...|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||:  ..:||.
Zfish   129 EIAEAYLGHRVNNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGRKGER 193

  Fly   209 NETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQ 273
            |     .|.:|:|......::::.:          :.:.:|.....|..|||.:...|:..:..:
Zfish   194 N-----VLIFDLGGGTFDVSILTIE----------DGIFEVKATAGDTHLGGEDFDNRMVKHFVE 243

  Fly   274 EFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLC 338
            ||.  :|.|.|::.:.||:.:|.....|.|..||::::...:|::|.|.|||...:||.:.|:|.
Zfish   244 EFK--RKHKKDISQNKRAVRRLRTACERAKRTLSSSSQASIEIDSLFEGIDFYTSITRARFEELN 306

  Fly   339 EDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATM 402
            .:|:.....|:|:||..:.:....|..::|.||.||:|::|:.::.... ::|.|::|.||:...
Zfish   307 AELFRGTLDPVEKALRDAKMDKSQIQDIVLVGGSTRIPKIQKLLQDFFNGRDLNKSINPDEAVAY 371

  Fly   403 GAVYKAADL--SAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVIT 465
            ||..:||.|  .....|:..::.|..  ||.:..|...|       |..||.......|.|:...
Zfish   372 GAAVQAAILMGDTSENVQDLLLLDVA--PLSLGIETAGG-------VMTALIKRNTTIPTKQTQI 427

  Fly   466 FNKHTDDFE-FYVNYADLDRYSKEEIAALGSLNVTKV--QLKQVKELLEKSKKELVDNKGIKAYF 527
            |:.::|:.. ..:...:.:|...::...||..::|.:  ..:.|.:              |:..|
Zfish   428 FSTYSDNQPGVLIQVFEGERAMTKDNNLLGKFDLTGIPPAPRGVPQ--------------IEVTF 478

  Fly   528 YLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEE 592
            .:|.:||...:              |.:.||               |:|.|
Zfish   479 DIDANGILNVS--------------AADKST---------------GKENK-------------- 500

  Fly   593 PSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQS 657
            .:.:.|..:..:||..:..:..|..|.:.|.:.|.|
Zfish   501 ITITNDKGRLSKEDIERMVQDAEKYKAEDEVQREKI----------------------------- 536

  Fly   658 VAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYE 722
                              :|.||||::...::..:::|:.....:.::|:|::.:|:.:..|| |
Zfish   537 ------------------AAKNALESYAFSMKNTVEDENLRGKISEQDKKKIIDKCTEVVSWL-E 582

  Fly   723 DLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            :.:..:.|.||....:|:.:.|..::|.::
Zfish   583 NNQLAEKEEYEHHQKELESVCNPIISRLYQ 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grp170	NP_569995.1	ASKHA_NBD_HSP70_HYOU1	21..409	CDD:466828	112/390 (29%)
		PTZ00121	<546..917	CDD:173412	32/207 (15%)
		TAF4	<572..>627	CDD:461598	9/54 (17%)
hspa1b	NP_001093532.1	PTZ00009	1..639	CDD:240227	171/745 (23%)