DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and hspa1l

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001072429.1	Gene:	hspa1l / 779883	XenbaseID:	XB-GENE-6045069	Length:	639	Species:	Xenopus tropicalis

Alignment Length:	752	Identity:	178/752 - (23%)
Similarity:	321/752 - (42%)	Gaps:	157/752 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPN 81
            |:|.|: .:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|:
Frog     3 SKGVAI-GIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPH 65

  Fly    82 SAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQ 146
            :.......|:|:..|.|:|....|.:|:..|....:....|..|.:...||.||:.:.:|.|.|:
Frog    66 NTVFDAKRLIGRKYDEPVVQSDMKHWPFKVISDGGKPKVTVEYKGEGKSFSPEEISSMVLTKMKE 130

  Fly   147 FAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGV--FHRGEIN 209
            .|:..:...:|..|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||:  ..|||.|
Frog   131 TAEAYLGYKVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKSGRGERN 195

  Fly   210 ETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQE 274
                 .|.:|:|......::::..          :.:.:|.....|..|||.:....:.::..:|
Frog   196 -----ILIFDLGGGTFDVSILTID----------DGIFEVKATAGDTHLGGEDFDNCMVNHFVEE 245

  Fly   275 FNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCE 339
            |.  :|.|.|::.:.|||.:|.....|.|..||::|:...:|::|.|.|||...:||.:.|:||.
Frog   246 FK--RKHKKDISPNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGIDFYTSITRARFEELCA 308

  Fly   340 DLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATMG 403
            ||:....:|:|:|:..:.|....|::::|.||.||:|:||:.::.... :||.|::|.||:...|
Frog   309 DLFRGTLEPVEKAMRDAKLDKSQIHEIVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYG 373

  Fly   404 AVYKAADLSAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVIT 465
            |..:||.|...   |...|:|..|.   ||.:..|...|       |...|.......|.|:..|
Frog   374 AAVQAAILMGD---KSENVQDLLLLDVAPLSLGLETAGG-------VMTVLIKRNTTIPIKQTQT 428

  Fly   466 FNKHTDD-----FEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKG--- 522
            |..::|:     .:.|    :.:|...::...||..::|.:....               :|
Frog   429 FTTYSDNQPGVLIQVY----EGERAMTKDNNLLGKFDLTGIPPAP---------------RGVPQ 474

  Fly   523 IKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAA 587
            |:..|.:|.:||...:.|:                                             .
Frog   475 IEVTFDIDANGILNVSAVD---------------------------------------------K 494

  Fly   588 NAGEEPSKSEDNEKAK--EEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLV 650
            ::|::...:..|:|.:  :|:..:..:..:..|.|.|.:.|.|
Frog   495 SSGKKNKITITNDKGRLSKEEIERMLQEADKYKADDEQQREKI---------------------- 537

  Fly   651 GSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECST 715
                                     :|.|:||::...::..:::.:.....:..:|:.:|.:|..
Frog   538 -------------------------AAKNSLESYAFNMKSTVEDNNIKDKISDSDKKSILDKCQE 577

  Fly   716 LGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            :..||.::....|.| |..|..:|:||.|..:.:.::
Frog   578 VISWLEQNQLAEKEE-YTHKQKELEKLCNPIITKLYQ 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	156/618 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	119/388 (31%)
		TAF4	<572..>627	CDD:296797	7/56 (13%)
hspa1l	NP_001072429.1	HSP70	2..639	CDD:331774	178/752 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910