DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and hspa8

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001103873.1	Gene:	hspa8 / 573376	ZFINID:	ZDB-GENE-990415-92	Length:	649	Species:	Danio rerio

Alignment Length:	751	Identity:	179/751 - (23%)
Similarity:	332/751 - (44%)	Gaps:	153/751 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LSQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDP 80
            :|:|.|| .:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|
Zfish     1 MSKGPAV-GIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNP 63

  Fly    81 NSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTV-VFRKSDTDEFSVEELVAQLLVKA 144
            .:.......|:|:..|:.:|....|.:| :|::.|..|..| |..|.::..|..||:.:.:|.|.
Zfish    64 TNTVFDAKRLIGRRFDDGVVQSDMKHWP-FNVINDNSRPKVQVEYKGESKSFYPEEISSMVLTKM 127

  Fly   145 KQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHR--GE 207
            |:.|:..:.:.::..|:|||.||..::|:|...|..::.|.||::||:..|.|:.||:..:  .|
Zfish   128 KEIAEAYLGKTVSNAVITVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKVGAE 192

  Fly   208 INETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLA 272
            .|     .|.:|:|......::::.:          :.:.:|.....|..|||.:...|:.::..
Zfish   193 RN-----VLIFDLGGGTFDVSILTIE----------DGIFEVKSTAGDTHLGGEDFDNRMVNHFI 242

  Fly   273 QEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQL 337
            .||.  :|.|.|::.:.||:.:|.....|.|..||::|:...:|::|.|.|||...:||.:.|:|
Zfish   243 TEFK--RKHKKDISDNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEEL 305

  Fly   338 CEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESAT 401
            ..||:.....|:|:||..:.:....|:.::|.||.||:|::|:.::.... :||.|::|.||:..
Zfish   306 NADLFRGTLDPVEKALRDAKMDKAQIHDIVLVGGSTRIPKIQKLLQDYFNGKELNKSINPDEAVA 370

  Fly   402 MGAVYKAADLSAGFK---VKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKV 463
            .||..:||.|| |.|   |:..::.|.|  ||.:..|...|       |...|.......|.|:.
Zfish   371 YGAAVQAAILS-GDKSENVQDLLLLDVT--PLSLGIETAGG-------VMTVLIKRNTTIPTKQT 425

  Fly   464 ITFNKHTDD-----FEFYVNYADLDRYSKEEIAALGSLNVTKV--QLKQVKELLEKSKKELVDNK 521
            .||..::|:     .:.|    :.:|...::...||...:|.:  ..:.|.:
Zfish   426 QTFTTYSDNQPGVLIQVY----EGERAMTKDNNLLGKFELTGIPPAPRGVPQ------------- 473

  Fly   522 GIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEA 586
             |:..|.:|.:||...:.|:....|:......::...|||
Zfish   474 -IEVTFDIDANGIMNVSAVDKSTGKENKITITNDKGRLSK------------------------- 512

  Fly   587 ANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVG 651
                      ||.|:..:|  :::.|:|:..::|.
Zfish   513 ----------EDIERMVQE--AEKYKAEDDVQRDK------------------------------ 535

  Fly   652 SAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTL 716
                                   .||.|.||::...::..:::|......:.|:|:|:|.:|:.:
Zfish   536 -----------------------VSAKNGLESYAFNMKSTVEDEKLKGKISDEDKQKILDKCNEV 577

  Fly   717 GEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            ..||.:: :..:.|.:|.:..:|:|:.|..:.:.::
Zfish   578 IGWLDKN-QTAEREEFEHQQKELEKVCNPIITKLYQ 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	158/616 (26%)
		HYOU1-like_NBD	23..409	CDD:212672	114/389 (29%)
		TAF4	<572..>627	CDD:296797	7/54 (13%)
hspa8	NP_001103873.1	HSP70	1..614	CDD:331774	179/751 (24%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		124/404 (31%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		26/141 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810