DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and AgaP_AGAP002076

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	XP_001689308.2	Gene:	AgaP_AGAP002076 / 5667627	VectorBaseID:	AGAP002076	Length:	656	Species:	Anopheles gambiae

Alignment Length:	744	Identity:	179/744 - (24%)
Similarity:	317/744 - (42%)	Gaps:	146/744 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAY 84
            |..:.:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|.:..
Mosquito     6 APAVGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTI 69

  Fly    85 GYLLDLLGKTIDNPIVDLYRKRFPY--YNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQF 147
            .....|:|:..|:|.:....|.:|:  .:|.|.|:  ..|..|.:...|..||:.:.:|.|.|:.
Mosquito    70 FDAKRLIGRKFDDPAIQADMKHWPFEVESIEGKPK--IAVEYKGEKKCFFPEEVSSMVLTKMKET 132

  Fly   148 AQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHR--GEINE 210
            |:..:.:.:|..|:|||.||..::|:|...|..::.|.||::||:..|.|:.||:..:  ||.|
Mosquito   133 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKTAGERN- 196

  Fly   211 TAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEF 275
                .|.:|:|......:::|..          :.:.:|.....|..|||.:...||.::.||||
Mosquito   197 ----VLIFDLGGGTFDVSILSID----------DGIFEVKSTAGDTHLGGEDFDNRLVNHFAQEF 247

  Fly   276 NALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCED 340
            .  :|.|.|::|:.|||.:|.....|.|..||::|:...:|::|.|..||...:||.:.|:|..|
Mosquito   248 K--RKHKKDLSTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNAD 310

  Fly   341 LWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATMGA 404
            |:....:|:|:||..:.:....|:.::|.||.||:|:||:.::.... :||.|::|.||:...||
Mosquito   311 LFRSTMEPVEKALRDAKMDKASIHDIVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGA 375

  Fly   405 VYKAADL--SAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFN 467
            ..:||.|  ....:|:..::.|.|  ||.:..|...|       |...|.......|.|:..||.
Mosquito   376 AVQAAILHGDKSEEVQDLLLLDVT--PLSLGIETAGG-------VMSVLIKRNTTIPTKQTQTFT 431

  Fly   468 KHTDDFE-FYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKG---IKAYFY 528
            .::|:.. ..:...:.:|...::...||...::.:....               :|   |:..|.
Mosquito   432 TYSDNQPGVLIQVFEGERAMTKDNNLLGKFELSGIPPAP---------------RGVPQIEVTFD 481

  Fly   529 LDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEP 593
            :|.:||...|.:                                   ||..|.|.:...
Mosquito   482 IDANGILNVTAL-----------------------------------EKSTNKENKITI------ 505

  Fly   594 SKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSV 658
              :.|..:..:||..:.....|..:.:.|.:.|||
Mosquito   506 --TNDKGRLSKEDIERMVNEAEKYRTEDEKQKETI------------------------------ 538

  Fly   659 AKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYED 723
                             ||.||||::...::..::::......|..:|..:|.:|:...:||..:
Mosquito   539 -----------------SAKNALESYCFNMKATMEDDKLKDKITDSDKTLVLDKCNDTIKWLDAN 586

  Fly   724 LEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            ....|.| ||.:..:|:.:.|..:::.::
Mosquito   587 QLADKEE-YEHRQKELESVCNPIISKLYQ 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	157/613 (26%)
		HYOU1-like_NBD	23..409	CDD:212672	121/390 (31%)
		TAF4	<572..>627	CDD:296797	9/54 (17%)
AgaP_AGAP002076	XP_001689308.2	PTZ00009	3..614	CDD:240227	179/742 (24%)
AgaP_AGAP002076	XP_001689308.2	HSPA1-2_6-8-like_NBD	8..383	CDD:212675	123/394 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810