DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and AgaP_AGAP004583

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	XP_001688624.2	Gene:	AgaP_AGAP004583 / 5667608	VectorBaseID:	AGAP004583	Length:	420	Species:	Anopheles gambiae

Alignment Length:	437	Identity:	132/437 - (30%)
Similarity:	224/437 - (51%)	Gaps:	32/437 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYG 85
            :.:.:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|.:...
Mosquito     3 SAIGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFSDTERLIGDAAKNQVAMNPTNTVF 66

  Fly    86 YLLDLLGKTIDNPIVDLYRKRFPY--YNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQFA 148
            ....|:|:..|:|.:....|.:|:  .|..|.| :..|.| |.:...|:.||:.:.:|.|.|:.|
Mosquito    67 DAKRLIGRRYDDPKIQADIKHWPFKVVNDCGKP-KIQVEF-KGERKTFAPEEVSSMVLTKMKETA 129

  Fly   149 QESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFH--RGEINET 211
            :..:...:...|:|||.||..::|:|...|..:|.|.|:::||:..|.||.||:..  :||.|
Mosquito   130 EAYLGHSVKNAVITVPAYFNDSQRQATKDAGAIAGLNVMRIINEPTAAALAYGLDKNLKGERN-- 192

  Fly   212 AQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFN 276
               .|.:|:|......:::         |.:...:.:|.....|..|||.:...|:..:..:||.
Mosquito   193 ---VLIFDLGGGTFDVSIL---------TIDEGSLFEVRATAGDTHLGGEDFDNRMVGHFVEEFK 245

  Fly   277 ALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDL 341
              :|.|.||:.:.|||.:|.....|.|..||::||...:|:.|::.||:...::|.:.|:||.||
Mosquito   246 --RKFKKDVSKNARALRRLRTACERAKRTLSSSTEATIEIDALMDGIDYYTKISRARFEELCSDL 308

  Fly   342 WPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVI-KQELGKNLNADESATMGAV 405
            :....:|:|:||:.:.:....|:.::|.||.||:|:||..::... .:.|..::|.||:...||.
Mosquito   309 FRSTLQPVEKALSDAKMDKSSIHDIVLVGGSTRIPKVQSLLQNFFCGKSLNLSINPDEAVAYGAA 373

  Fly   406 YKAADLSAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKR 449
            .:||.|| |.|.:|  ::|..|.   ||.:..|  ...|...|.::|
Mosquito   374 VQAAILS-GDKDEK--IQDVLLVDVAPLSLGIE--TAGGVMTKLIER 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	132/436 (30%)
		HYOU1-like_NBD	23..409	CDD:212672	117/390 (30%)
		TAF4	<572..>627	CDD:296797
AgaP_AGAP004583	XP_001688624.2	PRK13930	1..373	CDD:237564	116/388 (30%)
AgaP_AGAP004583	XP_001688624.2	HSPA1-2_6-8-like_NBD	4..380	CDD:212675	119/394 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810