DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and hspa14

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001038541.1	Gene:	hspa14 / 565232	ZFINID:	ZDB-GENE-041210-73	Length:	504	Species:	Danio rerio

Alignment Length:	528	Identity:	134/528 - (25%)
Similarity:	229/528 - (43%)	Gaps:	91/528 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYG 85
            |.:.|..|.....|.|...| ..::..|....|.|||::|:||..:.:|..|:...|::..:...
Zfish     2 AAIGVHFGYTCACVAVFKDG-RADVVANDAGDRVTPAVVAYRDTEQIVGIAAKQGRIRNAANTVV 65

  Fly    86 YLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKS-------DTDE----FSVEELVAQ 139
            .:..:||:..|:|....:::           |...:|..||       ||.|    .|.|::...
Zfish    66 KVKQILGRRYDDPDAQAHKE-----------ESKCIVVNKSGLPRYEIDTGETTKYVSPEDVAKL 119

  Fly   140 LLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFH 204
            :..|.|:.||.::...:.:.|:|||..|.:.::.||..||:.|...||:||::.:|..|.|.:..
Zfish   120 IFHKMKETAQSALGSDVKDAVITVPFEFDEMQKNALRQAAESAGFNVLRLIHEPSAALLAYDIGQ 184

  Fly   205 RGEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINP-VVQVLGVGYDRTLGGLEIQLRLR 268
            ...:.::  :.|.|.:|....|..|:           |:|. |.:||....|...||......|.
Zfish   185 DSPLGKS--HVLVYKLGGTSLSVTVL-----------EVNSGVYRVLATQTDHQTGGESFTQELA 236

  Fly   269 DYLAQEFNALKKT-KTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTRE 332
            .:||.||   ||| |.||:.:.||:.||...|...|:.||........:::|.:.:||:..|:|.
Zfish   237 QHLAAEF---KKTFKQDVSGNARAMMKLMNSADVAKHTLSTLGSANCFVDSLYDGMDFECNVSRA 298

  Fly   333 KLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQ-ELGKNLNA 396
            :.|.:|..|:.:..:|::..|...:||...:|:|:|.||..|:|::|:.|:.:... ||..::..
Zfish   299 RFELICSSLFNKCIQPIKSLLEQVNLSTSDVNKVVLSGGSARIPKLQQMIRDLFPDVELLNSIPP 363

  Fly   397 DESATMGAVYKAADLSAGFKVKK--------FVVKDATLFPLQVSFERDPGDGAAVKQVKRALFA 453
            ||...:||.     :.||..|.|        .:..|.....:.:....|.|     .:|...||.
Zfish   364 DEVIPVGAA-----MQAGILVGKDSLALGEDSITVDCCASDITLKEVDDSG-----LEVFTVLFP 418

  Fly   454 LMNPYPQKKVITFNKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLE------- 511
            ...|.|.::     :||                   :...|||:..::||.|.::.:.
Zfish   419 SGTPLPARR-----QHT-------------------LQGPGSLSSVRLQLFQAQQPIAQIVLGDL 459

  Fly   512 KSKKELVD 519
            :.|:||.|
Zfish   460 EPKEELHD 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	133/527 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	109/399 (27%)
		TAF4	<572..>627	CDD:296797
hspa14	NP_001038541.1	HSPA14-like_NBD	2..376	CDD:212680	110/406 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900