DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and HSPA14

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_057383.2	Gene:	HSPA14 / 51182	HGNCID:	29526	Length:	509	Species:	Homo sapiens

Alignment Length:	523	Identity:	141/523 - (26%)
Similarity:	230/523 - (43%)	Gaps:	77/523 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYG 85
            |.:.|.||.....|.|...|....:| |....|.|||::|:.:....:|..|:...|::.::...
Human     2 AAIGVHLGCTSACVAVYKDGRAGVVA-NDAGDRVTPAVVAYSENEEIVGLAAKQSRIRNISNTVM 65

  Fly    86 YLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDE---FSVEELVAQLLV-KAKQ 146
            .:..:||::..:|....|........|    |:|..:..:.||.|   |...|.||:|:. |.|:
Human    66 KVKQILGRSSSDPQAQKYIAESKCLVI----EKNGKLRYEIDTGEETKFVNPEDVARLIFSKMKE 126

  Fly   147 FAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINET 211
            .|...:.....:.|:|||..||:.::.||..||:.|...||:||::.:|..|.||:   |:.:.|
Human   127 TAHSVLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGI---GQDSPT 188

  Fly   212 AQ-YFLFYDMGAYKTSAAVVSYQLVKDKQTREINP-VVQVLGVGYDRTLGGLEIQLRLRDYLAQE 274
            .: ..|.:.:|....|.:|:           |:|. :.:||....|..:||......|..|||.|
Human   189 GKSNILVFKLGGTSLSLSVM-----------EVNSGIYRVLSTNTDDNIGGAHFTETLAQYLASE 242

  Fly   275 FNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCE 339
            |.  :..|.||..:.||:.||...|...|:.||........:::|.|..||...|:|.:.|.||.
Human   243 FQ--RSFKHDVRGNARAMMKLTNSAEVAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCS 305

  Fly   340 DLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQ-ELGKNLNADESATMG 403
            .|:.:..:.:...|..:..:.|.||:|:|.||.:|:|::|:.||.:... ||..::..||...:|
Human   306 PLFNKCIEAIRGLLDQNGFTADDINKVVLCGGSSRIPKLQQLIKDLFPAVELLNSIPPDEVIPIG 370

  Fly   404 AVYKAADLSAGFKVKK--FVVKDATLFPLQVSFERDPGDGAAVKQVKRA-------LFALMNPYP 459
            |.     :.||..:.|  .:|:|:.:.....   ||    ..||.|..:       ||....|.|
Human   371 AA-----IEAGILIGKENLLVEDSLMIECSA---RD----ILVKGVDESGASRFTVLFPSGTPLP 423

  Fly   460 QKKVITF-------------------NKHTDDFEF-YVNYADLDRYS---KEEIAAL-----GSL 496
            .::..|.                   |...::.:| .|...|||:..   ::.:|.|     |||
Human   424 ARRQHTLQAPGSISSVCLELYESDGKNSAKEETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSL 488

  Fly   497 NVT 499
            :||
Human   489 HVT 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	140/522 (27%)
		HYOU1-like_NBD	23..409	CDD:212672	112/392 (29%)
		TAF4	<572..>627	CDD:296797
HSPA14	NP_057383.2	HSPA14-like_NBD	2..376	CDD:212680	113/399 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900