DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and Hspa14

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_056580.2	Gene:	Hspa14 / 50497	MGIID:	1354164	Length:	509	Species:	Mus musculus

Alignment Length:	511	Identity:	139/511 - (27%)
Similarity:	224/511 - (43%)	Gaps:	57/511 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYG 85
            |.:.|.||.....|.|...| ..::..|....|.||||:|:.:..:.:|..|:...|:..:|...
Mouse     2 AAIGVHLGCTSACVAVYKDG-RADVVANDAGDRVTPAIVAYSEREQVVGLAAKQSRIRHVSSTVV 65

  Fly    86 YLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDE----FSVEELVAQLLVKAKQ 146
            .:..:||::..:|....|........|    |:|..:..:.||.|    .:.|::...:..|.|:
Mouse    66 KVKQILGRSSADPQAQKYISESKCLVI----EKNGKLRYEIDTGEETKLVNPEDVARLIFSKMKE 126

  Fly   147 FAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINET 211
            .|...:.....:.|:|||..||:.::.||..||..|...||:||::.:|..|.||:   |:.:.|
Mouse   127 TAHSVLGSDANDVVVTVPFDFGEKQKSALGEAAGAAGFNVLRLIHEPSAALLAYGI---GQDHPT 188

  Fly   212 AQ-YFLFYDMGAYKTSAAVVSYQLVKDKQTREINP-VVQVLGVGYDRTLGGLEIQLRLRDYLAQE 274
            .: ..|.:.:|....|.:|:           |:|. :.:||.......:||......|..|||.|
Mouse   189 GKSNVLVFKLGGTSLSLSVM-----------EVNSGMYRVLSTNTSDNIGGAHFTDTLAQYLASE 242

  Fly   275 FNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCE 339
            |..|  .|.||..:.||:.||...|...|:.||........:::|.|..||...|:|.:.|.||.
Mouse   243 FQRL--FKHDVRGNARAMMKLMNSAEVAKHSLSTLGSANCFVDSLYEGQDFDCNVSRARFELLCS 305

  Fly   340 DLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQ-ELGKNLNADESATMG 403
            .|:.:.|:.:.|.|..:..:.|.||:|:|.||.:|:|::|:.||.:... :|..::..||...:|
Mouse   306 PLFNKCTEAIRELLRQTGFTADDINKVVLCGGSSRIPKLQQLIKDLFPAVDLLNSIPPDEVIPIG 370

  Fly   404 AVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRA-------LFALMNPYPQK 461
            |..:|..|         |.|::|.....|..|....| ..||.|..:       ||....|.|.:
Mouse   371 AAIEAGIL---------VGKESTSGDDSVMIECSAKD-ILVKGVDESGADRFTVLFPSGTPLPAR 425

  Fly   462 KVITFNKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEK-SKKE 516
            :     :||......|:...|:.|..|      ..|..|.:.|..:.:|:. .|||
Mouse   426 R-----QHTLQAPGRVSSVCLELYESE------GKNSAKEEAKFAQVVLQDLDKKE 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	138/510 (27%)
		HYOU1-like_NBD	23..409	CDD:212672	110/392 (28%)
		TAF4	<572..>627	CDD:296797
Hspa14	NP_056580.2	HSPA14-like_NBD	2..376	CDD:212680	111/394 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900