Protein Alignment Grp170 and Hsp70Bc

DIOPT Version :10

• Sequence 1: NP_569995.1
• Gene: Grp170 / 31215
• FlyBaseID: FBgn0023529
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_650209.1
• Gene: Hsp70Bc / 48583
• FlyBaseID: FBgn0013279
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 737
• Identity: 195/737 - (26%)
• Similarity: 327/737 - (44%)
• Gaps: 160/737 - (21%)

  Fly    23 MSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYGYL 87
            :.:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|.:.....
  Fly     4 IGIDLGTTYSCVGVYQHG-KVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67

  Fly    88 LDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTV-VFRKSDTDEFSVEELVAQLLVKAKQFAQES 151
            ..|:|:..|:|.:....|.:| :.:|.|..:..: |..|.::..|:.||:.:.:|.|.|:.|:..
  Fly    68 KRLIGRKYDDPKIAEDMKHWP-FKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAY 131

  Fly   152 VQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFH--RGEINETAQY 214
            :.:.||:.|:|||.||..::|:|...|..:|.|.||::||:..|.||.||:..  :||.|
  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERN----- 191

  Fly   215 FLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALK 279
            .|.:|:|......:::         |.:...:.:|.....|..|||.:...||..:||:||.  :
  Fly   192 VLIFDLGGGTFDVSIL---------TIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFK--R 245

  Fly   280 KTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPR 344
            |.|.|:.::||||.:|...|.|.|..||::||...:|:.|.|..||...|:|.:.|:||.||:..
  Fly   246 KYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRN 310

  Fly   345 ATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQEL--GKNL----NADESATMG 403
            ..:|:|:||..:.:....|:.::|.||.||:|:||..:     ||.  ||||    |.||:...|
  Fly   311 TLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLL-----QEFFHGKNLNLSINPDEAVAYG 370

  Fly   404 AVYKAADLSA--GFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITF 466
            |..:||.||.  ..|::..::.|..  ||.:..|  ...|...|.::|..     ..|.|:..||
  Fly   371 AAVQAAILSGDQSGKIQDVLLVDVA--PLSLGIE--TAGGVMTKLIERNC-----RIPCKQTKTF 426

  Fly   467 NKHTDD-----FEFYVNYADLDRYSKEEIAALGSLNVTKV--QLKQVKELLEKSKKELVDNKGIK 524
            :.::|:     .:.|    :.:|...::..|||:.:::.:  ..:.|.:              |:
  Fly   427 STYSDNQPGVSIQVY----EGERAMTKDNNALGTFDLSGIPPAPRGVPQ--------------IE 473

  Fly   525 AYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANA 589
            ..|.||.:||.
  Fly   474 VTFDLDANGIL------------------------------------------------------ 484

  Fly   590 GEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAY 654
                     |..|||....|             |||     :|:|:.....||.: :..:|..|
  Fly   485 ---------NVSAKEMSTGK-------------AKN-----ITIKNDKGRLSQAE-IDRMVNEA- 520

  Fly   655 DQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEW 719
                .|.|  ::.|:.|.|:.|. ||||:::..|:|.:::....|...| :|..:|.:|:....|
  Fly   521 ----EKYA--DEDEKHRQRITSR-NALESYVFNVKQSVEQAPAGKLDEA-DKNSVLDKCNETIRW 577

  Fly   720 LYEDLEDPKAEIYEEKLAQLKK 741
            |..:....|.| ::.|:.:|.:
  Fly   578 LDSNTTAEKEE-FDHKMEELTR 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grp170	NP_569995.1	ASKHA_NBD_HSP70_HYOU1	21..409	CDD:466828	129/394 (33%)
		PTZ00121	<546..917	CDD:173412	37/196 (19%)
		TAF4	<572..>627	CDD:461598	8/54 (15%)
Hsp70Bc	NP_650209.1	PTZ00009	2..641	CDD:240227	195/737 (26%)