DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and AgaP_AGAP007682

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	XP_001237047.2	Gene:	AgaP_AGAP007682 / 4576741	VectorBaseID:	AGAP007682	Length:	1169	Species:	Anopheles gambiae

Alignment Length:	675	Identity:	165/675 - (24%)
Similarity:	299/675 - (44%)	Gaps:	93/675 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GIALSQGAAV-MSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIG 76
            |.|.|.|:.| :.:|.|:.:..||:...| ..||..|.....:.|:::||.:..|.:||:|....
Mosquito    19 GTAPSSGSTVAIGIDFGTSFSSVGIYRNG-KFEIIANECGNHRIPSVVAFTEKGRLVGEEALAQA 82

  Fly    77 IKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVEELVAQLL 141
            ..||.:....:..:||:         ::|           |....|..|.:|..:..||:...:|
Mosquito    83 DTDPANCVIEVKRILGR---------HKK-----------EGGLQVQFKGETKCYQPEEICGIIL 127

  Fly   142 VKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRG 206
            ...:..|:..:.:|:|..|:.||..|...:|:|:|.||.:|.|.||:|||:..|.|::.|: ::.
Mosquito   128 AHLRSMAERQLGEPVTCAVVAVPAQFSDGQRQAVLDAATIAGLSVLRLINEPTAAAISIGI-NKK 191

  Fly   207 EINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYL 271
            .|.|  ||.|....|......::|:.          .|.|.||.....|..|||::|..||.||.
Mosquito   192 LIGE--QYVLVCSFGGGFLDVSIVTI----------YNGVFQVKASSGDTRLGGVDIDKRLVDYF 244

  Fly   272 AQEFNALKKTKT-DVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLE 335
            .:|   |:.|:: |:|....|:.||.|...:.|..||..::...:|::|::.......:|::.::
Mosquito   245 VKE---LQDTQSLDITRDCIAMRKLRKTCEQAKRTLSYTSQVTVEIDDLLDGHKLSSTLTKDNVD 306

  Fly   336 QLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVI-KQELGKNLNADES 399
            :||:||:.|....:|.||..:......:::::|.|..:|:||||..:.... ::.|..::|:||:
Mosquito   307 ELCKDLFERVILHVETALRRARKDRFAMHEIMLVGESSRIPRVQIMLSEFFDRRSLSSSVNSDEA 371

  Fly   400 ATMGAVYKAADLSAGFKVKKFVVKDA---TLFPLQV-----SFERDPGDGAA-VKQVKRALFALM 455
            ..:|....|..||..   |...::|.   .|.|..:     ..:.|.|||.. |.:..|.|.:..
Mosquito   372 VVVGTAIAAGILSGD---KSCAIQDLLWWDLVPRSIGMISEELDIDGGDGGGDVGEPPRILISRN 433

  Fly   456 NPYPQKKVITFNKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDN 520
            :..|.|.     :|.     ..|:.::.|..:.| :|:.|.|:|..:|:     ||.|..|.:::
Mosquito   434 STLPLKV-----RHR-----VKNFRNVHRLYEGE-SAIVSDNITLGRLQ-----LEGSFGEGLED 482

  Fly   521 KGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEE 585
            .|:.  |.:|.:|:...          ..|.:.:..:||.|......::.....|.|:...|.|.
Mosquito   483 VGLS--FNVDLNGVLHV----------MVEGNIELKATLDKGRLERYEIDRIVYEHKRLILEMER 535

  Fly   586 AANAGEEPSKSEDNEKAKEEDASKEQKSEE---STKQDTEAKNETIKLVTVKSPVTYESQTQFVV 647
            .....|:..:.|.:..|..:...:||::|.   .|....:..:|.:..:.|   ||::.:
Mosquito   536 GQEEQEQRKRKETDHSAVIDRQGEEQEAEADDGGTVGTWDRFSEWLHCICV---VTFDLE----- 592

  Fly   648 PLVGSAYDQSVAKLAAINKAEEQRV 672
              :|.|.:....|...:.:.|:..:
Mosquito   593 --LGQAMELIYPKHVTLTEQEKMNI 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	153/617 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	104/387 (27%)
		TAF4	<572..>627	CDD:296797	11/57 (19%)
AgaP_AGAP007682	XP_001237047.2	prok_dnaK	29..568	CDD:274091	151/606 (25%)
		NBD_sugar-kinase_HSP70_actin	29..384	CDD:302596	105/391 (27%)
		DENN	691..>850	CDD:299760
		SPA	799..902	CDD:285780
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900