DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and Hsp68

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster

Alignment Length:	763	Identity:	195/763 - (25%)
Similarity:	316/763 - (41%)	Gaps:	165/763 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 MSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYGYL 87
            :.:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|.::....
  Fly     4 IGIDLGTTYSCVGVFQYG-KVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVFDA 67

  Fly    88 LDLLGKTIDNPIVDLYRKRFPY--YNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQFAQE 150
            ..|:|:..|:..:....|.:|:  .|..|.| :.:|.| |.....||.||:.:.:|.|.|:.|:.
  Fly    68 KRLIGRRFDDSKIQEDIKHWPFKVINDNGKP-KISVEF-KGANKCFSPEEISSMVLTKMKETAEA 130

  Fly   151 SVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFH--RGEINETAQ 213
            .:...:.:.|:|||.||..::|:|...|..:|.:.||::||:..|.||.||:..  :||.|
  Fly   131 YLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERN---- 191

  Fly   214 YFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNAL 278
             .|.:|:|......:::         |.:...:.:|.....|..|||.:...||.::.|:||.
  Fly   192 -VLIFDLGGGTFDVSIL---------TIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFK-- 244

  Fly   279 KKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWP 343
            :|.|.|:.::||||.:|...|.|.|..||::||...:|:.|.|..||...|:|.:.|:||.||:.
  Fly   245 RKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFR 309

  Fly   344 RATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVI-KQELGKNLNADESATMGAVYK 407
            ...:|:|:||..:.:....|:.::|.||.||:|:||..::... .:.|..::|.||:...||..:
  Fly   310 NTLEPVEKALKDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQ 374

  Fly   408 AADLSAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKRALFALMN---PYPQKKVITF 466
            ||.||..   |...:||..|.   ||.:..|  ...|...|.::|      |   |..|.|..|
  Fly   375 AAILSGD---KSSEIKDVLLVDVAPLSLGIE--TAGGVMTKLIER------NSRIPCKQSKTFT- 427

  Fly   467 NKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKGIKAYFYLDD 531
                       .|||             :.....:|:.:.:..|.|....|
  Fly   428 -----------TYAD-------------NQPAVTIQVFEGERALTKDNNVL-------------- 454

  Fly   532 SGIFRCTGVEYVYEKQKPED---DADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEP 593
             |.|..|||..........|   |.|.:..|
  Fly   455 -GTFDLTGVPPAPRGVPKIDVTFDLDANGIL---------------------------------- 484

  Fly   594 SKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSV 658
                 |..|||:...             .|||     :|:|:.....||...         |:.:
  Fly   485 -----NVTAKEQGTG-------------NAKN-----ITIKNDKGRLSQADI---------DRML 517

  Fly   659 AKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYED 723
            ::.....:.:|:..:..:|.|.||.::..|::.  .|:.....:|.:|..::..||...:||..:
  Fly   518 SEAEKYAEEDERHRQRIAARNQLETYLFGVKEA--AENGGDRISAADKSSIVERCSEAMKWLDSN 580

  Fly   724 LEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAE 771
            ....|.| ||.||.:|::..:            |...|..||..||.:
  Fly   581 TTAEKEE-YEYKLKELEQFCS------------PIMTKMHKGGGDGQQ 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	162/615 (26%)
		HYOU1-like_NBD	23..409	CDD:212672	122/390 (31%)
		TAF4	<572..>627	CDD:296797	7/54 (13%)
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	195/763 (26%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	124/393 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464222
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740