DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and Hsc70-2

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster

Alignment Length:	798	Identity:	188/798 - (23%)
Similarity:	333/798 - (41%)	Gaps:	195/798 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 MSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQT-IGIKDPNSAYGY 86
            :.:|||:.:..|||.. ...:||..|.:..|.||:.:||.:..|.||:.|:. :.:...|:.:.
  Fly     7 IGIDLGTTYSCVGVWQ-NSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFD- 69

  Fly    87 LLDLLGKTIDNPIVDLYRKRFPY--YNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQFAQ 149
            ...|:|:..|:..:....|.:|:  .|..|.| :..|.| |.:...|:.||:.:.:|.|.::.|:
  Fly    70 AKRLIGRKFDDKKIQEDLKLWPFKVINEKGKP-KIEVEF-KGERKRFAPEEISSMVLTKMREIAE 132

  Fly   150 ESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFH--RGEINETA 212
            ..:...:.:.|:|||.||..::|:|...|..:|.|.||::||:..|.||.||:..  :||.|
  Fly   133 VYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERN--- 194

  Fly   213 QYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNA 277
              .|.:|:|......:|:|.         :...:.:|.....|..|||.:...||.::.|:||.
  Fly   195 --VLIFDLGGGTFDVSVLSI---------DEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFK- 247

  Fly   278 LKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLW 342
             :|.|:|:..:.|||.:|.....|.|..||::||...:|:.|.|.|||...::|.:.|:|..||:
  Fly   248 -RKHKSDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLF 311

  Fly   343 PRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVI-KQELGKNLNADESATMGAVY 406
            ....:|:|.||:.:.:....|:.|:|.||.||:|::|:.::.:. .::|..::|.||:...||..
  Fly   312 RSTMQPVERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAV 376

  Fly   407 KAADLSAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKRALFALMN---PYPQKKVIT 465
            :||.|:.   |....::|..|.   ||.:..|  ...|.....|:|      |   |..|:::.|
  Fly   377 QAAILTG---VGSSQIQDLLLVDVAPLSLGIE--TAGGVMTNLVER------NARIPCKQQQIFT 430

  Fly   466 FNKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKGIKAYFYLD 530
                        .|:|             :.|...:|:.:.:..:.|....|
  Fly   431 ------------TYSD-------------NQNAVTIQVYEGERAMTKDNNLL------------- 457

  Fly   531 DSGIFRCTG----------VEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEE 585
              |.|..||          :|..:       |.:.|..|:              ...||||
  Fly   458 --GTFNLTGIPPAPRGVPQIEVAF-------DLNADGILN--------------VNAKDNS---- 495

  Fly   586 AANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLV 650
               .|:....:..|:|.:...|..::...|:.|...|
  Fly   496 ---TGKSEKITISNDKGRLSKAEIDRMLSEAEKYKVE---------------------------- 529

  Fly   651 GSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECST 715
                            .:.||.|::|. |.|||:|...:|.:| ::.:...:..|:.|:..:||:
  Fly   530 ----------------DDRQRERVQSK-NNLEAYIYACRQAVD-DAPSGVLSETERSKVRDKCSS 576

  Fly   716 LGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVTGR-N 779
            ...||.::....|.| :|..|.:.:::....:::                 |.|.:|    |: :
  Fly   577 EASWLDKNSLAEKEE-FESHLKECQRICTPIMSK-----------------IHGGKK----GKSS 619

  Fly   780 LTKDTNPEKDVFTQVEID 797
            :.|.::|     |..|:|
  Fly   620 MGKGSHP-----TVEEVD 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	158/623 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	117/391 (30%)
		TAF4	<572..>627	CDD:296797	11/54 (20%)
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	187/796 (23%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	119/394 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740