DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and Hsc70Cb

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster

Alignment Length:	912	Identity:	233/912 - (25%)
Similarity:	401/912 - (43%)	Gaps:	107/912 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYG 85
            :|:.:|.|:|...|.....| .:|...|..|.|.||:.:||....|.||..|:...:.:..:..|
  Fly     2 SVIGIDFGNESCYVAAARSG-GIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVG 65

  Fly    86 YLLDLLGKTIDNPIVDLYRKRFP-YYNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQFAQ 149
            ....|||:..::|.|.......| .....||......|....:...|..|:|.|.|..|.|:.:.
  Fly    66 GFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130

  Fly   150 ESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINETAQY 214
            .::|..:.:||:..|.:|..|||:|||.|||:|.|.||:|:|:..|.||.||.:......:..:.
  Fly   131 AAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRN 195

  Fly   215 FLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALK 279
            .:|.|.|.....|:..::  .|.|        :::|...:|: :||.:|.|.|.||.|:||.  :
  Fly   196 VIFVDFGHSSLQASACAF--TKGK--------LKMLASTWDQ-IGGRDIDLALGDYFAKEFQ--E 247

  Fly   280 KTKTDVTTSPRALAKLFKEAGRLKNVLSAN-TEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWP 343
            :.|.:..|:.||..:|..|..:||..:||| |:....||..::|||....:.|.::|:||..:..
  Fly   248 RYKINAKTNARANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQ 312

  Fly   344 RATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESATMGAVYKA 408
            |..:..:..||.|.|.||.|:.|.:.||.:|:|.|::.|:.|..:.....||.||:.:.||..:.
  Fly   313 RVEQTFKRLLAESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQC 377

  Fly   409 ADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFNKHTDDF 473
            |.:|...:|::|.|.|...:.::|.:  |....||..:::  :|...:..|..:::|.|: ...|
  Fly   378 AIMSPAVRVREFGVTDIQNYAVKVLW--DSEGSAAPGEIE--IFPQYHASPFSRLLTINR-KGPF 437

  Fly   474 EFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKGIKAYFYLDDSGIFRCT 538
            ...:.|.....|..:      ::.|.||  |.||      ..|..:.:.:|....::::||...:
  Fly   438 NVSIVYGQQVPYPDQ------TIGVWKV--KDVK------PTERGEGQDVKLKVRINNNGIVLIS 488

  Fly   539 GVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSE----QEEAANAGEEPSKSEDN 599
            ....|.:|:..|..|..:...|:         .|.|::..:..|    |:||....|     :||
  Fly   489 SATLVEKKEAEEAAAAAEQAASE---------EKPGDQTNNTGEPADGQQEAYCENE-----DDN 539

  Fly   600 EKAKEED-----------------ASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVV 647
            ..:....                 |.|::|:.::|:                  :..|..|....
  Fly   540 NTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATE------------------LPLECTTHGFS 586

  Fly   648 PLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAE 712
            |:..|.|.|..:|:...::.|.:|:   .|.||||..:.:::.||....:.:.....|:||::::
  Fly   587 PVDLSNYTQQESKMIGNDQKETERI---DAKNALEEFVYDMRNKLQGGPFERYVVEAEREKIVSQ 648

  Fly   713 CSTLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVTG 777
            .:.|..|||||.||.:.:||..:|..|.:.::....|..::|:.|.|...||..|..|...:...
  Fly   649 LNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELKNSIAIARLAVAEF 713

  Fly   778 RNLTKDTNPEKDVFTQVEIDTLDKVITETNAWLKTETAAQKKLAKNADIRLTVKDITDKMSLLDR 842
            |...    |:.|..|:.|...:.:...:..:||........:..:.||..:.:..:..::..|:.
  Fly   714 RKGV----PKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSPVQISAVRQEVQTLNS 774

  Fly   843 EVKYLVNKIKIWKPKVKPAAEKEKKKEEEVV-------ASGSGDDTKSEDAEQQQEQATKEEQQE 900
            .|..::|:.   |||..||......|:|...       |:.|||  |.:.....|..|..:...|
  Fly   775 CVSSVINRA---KPKPTPAKTATPPKDEANAEQNGGEPAANSGD--KMDVDNNGQSAAGNDPSME 834

  Fly   901 QE 902
            .|
  Fly   835 VE 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	166/625 (27%)
		HYOU1-like_NBD	23..409	CDD:212672	120/387 (31%)
		TAF4	<572..>627	CDD:296797	13/75 (17%)
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	122/392 (31%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	197/746 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464195
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45639
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840