Protein Alignment Grp170 and Hsc70-1

DIOPT Version :10

• Sequence 1: NP_569995.1
• Gene: Grp170 / 31215
• FlyBaseID: FBgn0023529
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 743
• Identity: 175/743 - (23%)
• Similarity: 310/743 - (41%)
• Gaps: 150/743 - (20%)

  Fly    23 MSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYGYL 87
            :.:|||:.:..|||...| .:||..|.:..|.||:.:||.:..|.||:.|:.....:||:.....
  Fly     7 VGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIFDA 70

  Fly    88 LDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQFAQESV 152
            ..|:|:..|:..|....|.:|:.....:.:....|..|.:...|..||:.:.:|.|.::.|:..:
  Fly    71 KRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAYL 135

  Fly   153 QQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINETAQYFLF 217
            ...:|:.|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||:..:|   .:.:..|.
  Fly   136 GGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQG---TSERNVLI 197

  Fly   218 YDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALKKTK 282
            :|:|......:|::.:          :.:.:|.....|..|||.:...||.::..|||.  :|.|
  Fly   198 FDLGGGTFDVSVLTIE----------DGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQ--RKHK 250

  Fly   283 TDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATK 347
            .|:..:.|||.:|.....|.|..||::|:...:|::|.|.:||...|||.:.|:|..||:....:
  Fly   251 KDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTME 315

  Fly   348 PLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATMGAVYKAADL 411
            |:.:||..:.:....|:.::|.||.||:|:||..::.... :||.|::|.||:...||..:||.|
  Fly   316 PVAKALRDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAIL 380

  Fly   412 SAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFNKHTDDF 473
            ...   |...|:|..|.   ||.:..|...|       |...|.......|.|:.
  Fly   381 HGD---KSEAVQDLLLLDVTPLSLGIETAGG-------VMTTLIKRNTTIPTKQT---------- 425

  Fly   474 EFYVNYAD------LDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKG---IKAYFYL 529
            :.:..|||      :..:..|......:.::.|.:|..:...          .:|   ::..|.:
  Fly   426 QIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKFELSAIPPA----------PRGVPQVEVTFDI 480

  Fly   530 DDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPS 594
            |.:||...|.:|                                             .:.|:|..
  Fly   481 DANGILNVTALE---------------------------------------------KSTGKENR 500

  Fly   595 KSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVA 659
            .:..|:|.:   .|||  ..|....|.|                              ||.|:
  Fly   501 ITITNDKGR---LSKE--DIERMVNDAE------------------------------AYRQA-- 528

  Fly   660 KLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDL 724
                   .|:||.|: :|.|.||::..:::..||:|..:...:..::|.:....|....||..:.
  Fly   529 -------DEQQRDRI-NAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQ 585

  Fly   725 EDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            ...:.| :|.|..:|:::.:..:.|.::
  Fly   586 LAERQE-FEHKQQELERICSPIITRLYQ 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grp170	NP_569995.1	ASKHA_NBD_HSP70_HYOU1	21..409	CDD:466828	114/386 (30%)
		PTZ00121	<546..917	CDD:173412	33/207 (16%)
		TAF4	<572..>627	CDD:461598	10/54 (19%)
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	175/743 (24%)