Protein Alignment Grp170 and hsc70

DIOPT Version :10

• Sequence 1: NP_569995.1
• Gene: Grp170 / 31215
• FlyBaseID: FBgn0023529
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_956908.1
• Gene: hsc70 / 393586
• ZFINID: ZDB-GENE-040426-1221
• Length: 647
• Species: Danio rerio
• Alignment Length: 752
• Identity: 177/752 - (23%)
• Similarity: 326/752 - (43%)
• Gaps: 155/752 - (20%)

  Fly    16 LSQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDP 80
            :|:|.|| .:|||:.:..||:...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|
Zfish     1 MSKGPAV-GIDLGTTYSCVGIFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNP 63

  Fly    81 NSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAK 145
            ::.......|:|:..|:|:|....|.:|:..|....:....|..|.:...|..||:.:.:|.|.|
Zfish    64 SNTVFDAKRLIGRRFDDPVVQSDMKHWPFKVISDGSKPKMEVEYKGEIKTFFPEEVSSMVLTKMK 128

  Fly   146 QFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHR--GEI 208
            :.::..:.:.::..|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||:..:  ||.
Zfish   129 EISEAYLGKTVSNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGGER 193

  Fly   209 NETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQ 273
            |     .|.:|:|......::::.:          :.:.:|.....|..|||.:...|:.::...
Zfish   194 N-----VLIFDLGGGTFDVSILTIE----------DGIFEVKSTAGDTHLGGEDFDNRMVNHFIT 243

  Fly   274 EFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLC 338
            ||.  :|.|.|:|.:.||:.:|.....|.|..||::|:...:|::|.|..||...:||.:.|:|.
Zfish   244 EFK--RKFKKDITGNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGADFYTSITRARFEELN 306

  Fly   339 EDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATM 402
            .||:....:|:|:||..:.:....|:.::|.||.||:|::|:.::.... ::|.|::|.||:...
Zfish   307 ADLFRGTLEPVEKALRDAKMDKAQIHDIVLVGGSTRIPKIQKLLQDFFNGRDLNKSINPDEAVAY 371

  Fly   403 GAVYKAADLS--AGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVIT 465
            ||..:||.|:  ....|:..::.|.|  ||.:..|...|       |...|.......|.|:..|
Zfish   372 GAAVQAAILTGDTSENVQDLLLLDVT--PLSLGIETAGG-------VMTVLIKRNTTIPTKQTQT 427

  Fly   466 FNKHTDD-----FEFYVNYADLDRYSKEEIAALGSLNVTKVQ-----LKQVKELLEKSKKELVDN 520
            |..::|:     .:.|    :.:|...::...||...:|.:.     :.|::...:      :|.
Zfish   428 FTTYSDNQPGVLIQVY----EGERAMTKDNNILGKFELTGIPPAPRGVPQIEVTFD------IDA 482

  Fly   521 KGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEE 585
            .||     |:.|.:.:.||.|             ...|::.....|||
Zfish   483 NGI-----LNVSAVDKSTGKE-------------NKITITNDKGRLSK----------------- 512

  Fly   586 AANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLV 650
                       ||.|:..:| |.:.:..:|..::...|||            |.||
Zfish   513 -----------EDIERMVQE-ADQYRAEDEVQREKVTAKN------------TLES--------- 544

  Fly   651 GSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECST 715
                                     .|||        ::..::::......:.|:|:.:..:|:.
Zfish   545 -------------------------LAFN--------MKSTVEDDKLQDKISPEDKKTITDKCNE 576

  Fly   716 LGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            :..||.::....|.| ||.:..:|:|:.|..:.:.::
Zfish   577 VISWLDKNQTAEKDE-YEHQQKELEKVCNPIITKLYQ 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grp170	NP_569995.1	ASKHA_NBD_HSP70_HYOU1	21..409	CDD:466828	113/390 (29%)
		PTZ00121	<546..917	CDD:173412	31/207 (15%)
		TAF4	<572..>627	CDD:461598	9/54 (17%)
hsc70	NP_956908.1	PTZ00009	1..612	CDD:240227	177/750 (24%)