DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and hspa5

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_998223.1	Gene:	hspa5 / 378848	ZFINID:	ZDB-GENE-031001-11	Length:	650	Species:	Danio rerio

Alignment Length:	753	Identity:	192/753 - (25%)
Similarity:	317/753 - (42%)	Gaps:	152/753 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLLLSALLAGIALSQG-------AAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAF 61
            :|.|..|:||...::.       ..|:.:|||:.:..|||...| .:||..|.:..|.||:.:||
Zfish     3 LLCLFLLVAGSVFAEEDDKKESVGTVIGIDLGTTYSCVGVYKNG-RVEIIANDQGNRITPSYVAF 66

  Fly    62 -RDGTRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNI-----------VG 114
             .:|.|.||:.|:.....:|.:.......|:|:|..:..|....|.||:..|           :|
Zfish    67 TTEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWGDSSVQQDIKYFPFKVIEKKNKPHIQLDIG 131

  Fly   115 DPERNTVVFRKSDTDEFSVEELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAA 179
            ..:..|          |:.||:.|.:|.|.|:.|:..:.:.:|..|:|||.||..|:|:|...|.
Zfish   132 SGQMKT----------FAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAG 186

  Fly   180 QLANLKVLQLINDYAAVALNYGVFHR-GEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREI 243
            .:|.|.|:::||:..|.|:.||:..| ||.|     .|.:|:|......::::..
Zfish   187 TIAGLNVMRIINEPTAAAIAYGLDKRDGEKN-----ILVFDLGGGTFDVSLLTID---------- 236

  Fly   244 NPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSA 308
            |.|.:|:....|..|||.:...|:.::..:.:.  |||..||....||:.||.:|..:.|..|||
Zfish   237 NGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYK--KKTGKDVRKDNRAVQKLRREVEKAKRALSA 299

  Fly   309 NTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGT 373
            ..:...:||:..|..||...:||.|.|:|..||:....||:::.|..|......|::::|.||.|
Zfish   300 QHQARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDPKKPDIDEIVLVGGST 364

  Fly   374 RVPRVQETIKAVIK-QELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERD 437
            |:|::|:.:|.... :|..:.:|.||:...||..:|..||...:....|:.|  :.||.:..|
Zfish   365 RIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGEEETGDLVLLD--VCPLTLGIE-- 425

  Fly   438 PGDGAAVKQVKRALFALMNPYPQKKVITF-----NKHTDDFEFYVNYADLDRYSKEEIAALGSLN 497
                 .|..|...|.......|.||...|     |:.|...:.|    :.:|...::...||:.:
Zfish   426 -----TVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVY----EGERPLTKDNHLLGTFD 481

  Fly   498 VTKV--QLKQVKELLEKSKKELVDNKGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLS 560
            :|.:  ..:.|.:              |:..|.:|.:||.|.|              |::..|.:
Zfish   482 LTGIPPAPRGVPQ--------------IEVTFEIDVNGILRVT--------------AEDKGTGN 518

  Fly   561 KFGSTLS---KLFTKEGEEKKDNSEQEEAANAGEEPSKSED-----NE------KAKEEDASKEQ 611
            |...|::   ...|.|..|:..|    ||....:|..|.::     ||      ..|.:...||:
Zfish   519 KNKITITNDQNRLTPEDIERMVN----EAERFADEDKKLKERIDSRNELESYAYSLKNQIGDKEK 579

  Fly   612 KSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKAEEQRVRLES 676
            ...:.:.:|.||                          :..|.::.:..|.|...|:     ||.
Zfish   580 LGGKLSSEDKEA--------------------------IEKAVEEKIEWLEAHQDAD-----LEE 613

  Fly   677 AFNALEAHIIEVQQKLDEESYAKCA-----TAEEKEKL 709
             |.|.:..:.||.|.:..:.|....     .||||::|
Zfish   614 -FQAKKKELEEVVQPIVSKLYGSAGGPPPEEAEEKDEL 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	170/637 (27%)
		HYOU1-like_NBD	23..409	CDD:212672	119/399 (30%)
		TAF4	<572..>627	CDD:296797	15/65 (23%)
hspa5	NP_998223.1	HSPA5-like_NBD	26..401	CDD:212681	120/402 (30%)
		PTZ00009	29..641	CDD:240227	181/716 (25%)
		Periplasmic_Binding_Protein_Type_2	<583..640	CDD:304360	15/88 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910