DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and hspa9

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_958483.2	Gene:	hspa9 / 373085	ZFINID:	ZDB-GENE-030828-12	Length:	682	Species:	Danio rerio

Alignment Length:	745	Identity:	179/745 - (24%)
Similarity:	295/745 - (39%)	Gaps:	172/745 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAF-RDGTRTIGEDAQTIGIKDPNSAY 84
            ||:.:|||:....|.|:. |...::..|.|..|.||:::|| .||.|.:|..|:...:.:||:..
Zfish    57 AVIGIDLGTTNSCVAVMD-GKNAKVLENAEGARTTPSVVAFTSDGERLVGMPAKRQAVTNPNNTL 120

  Fly    85 GYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDE--------FSVEELVAQLL 141
            .....|:|:..|:..|....|..||           .:.|.|:.|.        :|..:..|.:|
Zfish   121 YATKRLIGRRFDDAEVQKDLKNVPY-----------KIVRASNGDAWLEVHGKMYSPSQAGAFIL 174

  Fly   142 VKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRG 206
            :|.|:.|:..:.|.:...|:|||.||..::|:|...|.|:|.|.||::||:..|.||.||
Zfish   175 IKMKETAESYLGQSVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYG----- 234

  Fly   207 EINETAQYFL-FYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDY 270
             :::|....: .||:|......:|:..|          ..|.:|.....|..|||.:....|..:
Zfish   235 -LDKTQDKIIAVYDLGGGTFDISVLEIQ----------KGVFEVKSTNGDTFLGGEDFDQHLLRH 288

  Fly   271 LAQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDID----FKLPVTR 331
            :.:||.  |::..|:.....||.::.:.|.:.|..||::.:....:..|..|..    ..:.:||
Zfish   289 IVKEFK--KESGVDLMKDNMALQRVREAAEKAKCELSSSLQTDINLPYLTMDASGPKHLNMKLTR 351

  Fly   332 EKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNA 396
            .:.|.:..||..|...|.::|:..:.:|...|.:|:|.||.||:|:||:|::.:..:...|::|.
Zfish   352 SQFEGIVADLIRRTVAPCQKAMQDAEVSKSDIGEVLLVGGMTRMPKVQQTVQDLFGRAPSKSVNP 416

  Fly   397 DESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQK 461
            ||:..:||..:...|:.  .|...::.|.|  ||.:..|  ...|...|.:.|     ....|.|
Zfish   417 DEAVAIGAAIQGGVLAG--DVTDVLLLDVT--PLSLGIE--TLGGVFTKLINR-----NTTIPTK 470

  Fly   462 KVITFNKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNK----- 521
            |...|:...|                         ..|:|::|    :.:..::...|||
Zfish   471 KSQVFSTAAD-------------------------GQTQVEIK----VCQGEREMATDNKVLGQF 506

  Fly   522 -------------GIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKE 573
                         .|:..|.:|.:||        |:...|.:....|...:.:....||
Zfish   507 TLVGIPPALRGVPQIEVTFDIDANGI--------VHVSAKDKGTGREQQIVIQSSGGLS------ 557

  Fly   574 GEEKKDNSEQEEAANAGEEPSKSEDNEKAKEEDASKEQKSE-----ESTKQDTEAKNETIKLVTV 633
                ||:.|           :..::.||..|||..::.:.|     |....|||:|.|..|
Zfish   558 ----KDDIE-----------NMVKNAEKYAEEDRRRKDRVEAVNMAEGIVHDTESKMEEFK---- 603

  Fly   634 KSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKAEEQRVR-------LESAFNALEAHIIEVQQ- 690
                                 ||..|......|.|..:||       .|:..|..:| ...:||
Zfish   604 ---------------------DQLPADECNKLKEEISKVRELLSRKDTETGENIKQA-ATSLQQA 646

  Fly   691 --KLDEESYAKCATAEEKEKLLAECSTLGE 718
              ||.|.:|.|.|:..|.....:.....||
Zfish   647 SLKLFEMAYKKMASEREGSSGSSSSGEAGE 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	154/639 (24%)
		HYOU1-like_NBD	23..409	CDD:212672	109/399 (27%)
		TAF4	<572..>627	CDD:296797	14/59 (24%)
hspa9	NP_958483.2	HSPA9-like_NBD	55..431	CDD:212683	111/403 (28%)
hspa9	NP_958483.2	dnaK	56..659	CDD:234715	175/726 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900