DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and Hsc70-5

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	715	Identity:	180/715 - (25%)
Similarity:	299/715 - (41%)	Gaps:	147/715 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAF-RDGTRTIGEDAQTIGIKDPNSAY 84
            ||:.:|||:....:.|:. |...::..|.|..|.||:.:|| :||.|.:|..|:...:.:..:.:
  Fly    53 AVIGIDLGTTNSCLAVME-GKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTF 116

  Fly    85 GYLLDLLGKTIDNP-----IVDLYRKRFPYYNIVGDPERNTVVFRKSDTD--EFSVEELVAQLLV 142
            .....|:|:..|:|     |.:|      .|.:|.....:..|   |.||  .:|..::.|.:|:
  Fly   117 YATKRLIGRRFDDPEVKKDITNL------SYKVVKASNGDAWV---SSTDGKVYSPSQIGAFILM 172

  Fly   143 KAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGE 207
            |.|:.|:..:..|:...|:|||.||..::|:|...|.|:|.|.||::||:..|.||.||
  Fly   173 KMKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYG------ 231

  Fly   208 INETAQYFL-FYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYL 271
            :::|....: .||:|......:::..|          ..|.:|.....|..|||.:....:.::|
  Fly   232 MDKTEDKIIAVYDLGGGTFDISILEIQ----------KGVFEVKSTNGDTLLGGEDFDNHIVNFL 286

  Fly   272 AQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDI----DFKLPVTRE 332
            ..||.  |.:..|:.....|:.:|.:.|.:.|..||::.:....:..|..|.    ...|.:||.
  Fly   287 VAEFK--KDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRS 349

  Fly   333 KLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNAD 397
            |||.|..||..|..:|.::||:.:.:|...|.:|:|.||.||:|:||.|::.:..::..:::|.|
  Fly   350 KLESLVGDLIKRTIQPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPD 414

  Fly   398 ESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKK 462
            |:..:||..:...|:.  .|...::.|.|  ||.:..|...|       |...|.:.....|.||
  Fly   415 EAVAVGAAVQGGVLAG--DVTDVLLLDVT--PLSLGIETLGG-------VFTRLISRNTTIPTKK 468

  Fly   463 VITFNKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELV-DNK----- 521
            ...|:..:|                         ..|:|::|     :.:.::|:. |||
  Fly   469 SQVFSTASD-------------------------GQTQVEIK-----VHQGEREMANDNKLLGSF 503

  Fly   522 -------------GIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSK----L 569
                         .|:..|.:|.:||        |:...|.:....|...:.:....|||    .
  Fly   504 TLVGIPPAPRGVPQIEVVFDIDANGI--------VHVSAKDKGTGKEQQIVIQSSGGLSKDEIEN 560

  Fly   570 FTKEGEE----KKDNSEQEEAANAGE----------EPSKS----EDNEKAKEED-------ASK 609
            ..|:.||    .|...|..|..|.||          |..||    |:.||.|:|.       |:|
  Fly   561 MIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIADLRTLLANK 625

  Fly   610 EQKS-EESTKQDTEAKNETIKLVTV---KSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKAEEQ 670
            |... ||..|..:..:..::||..:   |.....||...     .||:...|.:..:...|.||:
  Fly   626 ETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAG-----AGSSDSSSSSDTSGEAKKEEK 685

Fly 671 670
Fly 686 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	168/664 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	111/398 (28%)
		TAF4	<572..>627	CDD:296797	23/80 (29%)
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	174/694 (25%)
		HSPA9-like_NBD	51..428	CDD:212683	113/402 (28%)
		Syntaphilin	<566..>642	CDD:291936	22/75 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464207
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830