DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and hspa4a

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_999881.1	Gene:	hspa4a / 335865	ZFINID:	ZDB-GENE-040426-2832	Length:	833	Species:	Danio rerio

Alignment Length:	923	Identity:	243/923 - (26%)
Similarity:	421/923 - (45%)	Gaps:	112/923 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKD-PNSAY 84
            :|:..|:|.:...|.|...| .:|...|..|.|.||:.::|....|:||..|::..:.: .|:..
Zfish     2 SVVGFDVGFQSCYVAVARAG-GIETVANEYSDRCTPSFVSFGPRNRSIGAAAKSQVVTNCKNTVQ 65

  Fly    85 GYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNT--VVFRKSDTDEFSVEELVAQLLVKAKQF 147
            |: ....|:...:|.|:..:... .|::...|...|  .|....:...|.:|::.|.||.|.|:.
Zfish    66 GF-KRFHGRAFSDPYVETTQSSL-VYDLAQMPNGTTGIKVMYMEEEKLFGIEQVTAMLLTKLKET 128

  Fly   148 AQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRG--EINE 210
            |:.::::|:.:||::||.||..|||.:::.|||:|.|..|:|:||..||||.||::.:.  ...|
Zfish   129 AESALKKPVADCVISVPSYFTDAERRSVMDAAQIAGLNCLRLMNDTTAVALAYGIYKQDLPAPEE 193

  Fly   211 TAQYFLFYDMG--AYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQ 273
            ..:..:|.|:|  .|:.||...:    |.|        ::|||..:|..|||.:....|..:..:
Zfish   194 KPRTVVFVDVGHAGYQVSACAFN----KGK--------LKVLGSAFDPELGGKDFDEVLVKHFCE 246

  Fly   274 EFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSAN-TEFFAQIENLIEDIDFKLPVTREKLEQL 337
            ||  .:|.|.||.:.||||.:|::|..:||.::||| ::....||..:.|||....:.|.|.|:|
Zfish   247 EF--AQKYKLDVRSKPRALVRLYQECEKLKKLMSANSSDLPLNIECFMNDIDVSSKLNRAKFEEL 309

  Fly   338 CEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESATM 402
            |..|..:...||:..:..:.|..:.|..|.:.||.:|:|.::|.|.....:||...||.||:...
Zfish   310 CAGLLAKVEAPLQSIMEQTRLKKEDIYAVEIIGGASRIPAIKERISKFFGKELSTTLNLDEAVAR 374

  Fly   403 GAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITF- 466
            |...:.|.||..|||::|.:.|...:|:.:.:.....:|.:..:|    |...:..|..||:||
Zfish   375 GCALQCAILSPAFKVREFSITDVVPYPISLKWTSAADEGVSDCEV----FPKNHAAPFSKVLTFY 435

  Fly   467 NKHTDDFEFYVN------YADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKGIKA 525
            .|.....|.|.|      |.|         ..:|...:.||    |.:...:|.|       :|.
Zfish   436 RKEPFTLEAYYNNPKALPYPD---------PTIGQFTIHKV----VPQASGESSK-------VKV 480

  Fly   526 YFYLDDSGIFRCTGVEYVYEKQKP---EDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAA 587
            ...::..|:|..:....| |..||   |:..:.|:.            .|:.|.|....::.:.|
Zfish   481 KVRVNVHGVFSVSSASLV-ELLKPGEGEEPMETDTP------------AKDEENKMQVDQEAQKA 532

  Fly   588 NAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGS 652
            .|.::..:::.....::.:.|.|.|.|:...|..:||...:|..||..|:....|.|.....: :
Zfish   533 QADDQKEQADKKSDTEDMETSPEDKQEKKNDQPPQAKKAKVKTKTVDLPIMNSLQWQLASDAL-N 596

  Fly   653 AYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDE--ESYAKCATAEEKEKLLAECST 715
            .:.::..|:...:|.|::|   ..|.|.:|.::.|::.||..  |::...|   |::....:...
Zfish   597 LFMENEGKMIMQDKLEKER---NDAKNYVEEYVYEMRDKLHGVLENFVSEA---ERDSFSLKLED 655

  Fly   716 LGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVTGRNL 780
            ...||||:.||.:.::|.:|||:||||.:...:|:.|.|.||:|.:.|...|....|.:    ..
Zfish   656 TENWLYEEGEDQQKQVYIDKLAELKKLGDPIQSRYIEAEVRPKAFEELGRQIQLYMKVV----EA 716

  Fly   781 TKDTNPEKDVFTQVEIDTLDKVITETNAWLKTETAAQKKLAKNADIRLTVKDITDKMSLLDREVK 845
            .|..:...|...::|:..::|.:.:...|:..:...|.|.:.:.|..:.|::|..|...|.....
Zfish   717 FKAKDELYDHLDELEMVKVEKQVNDAMTWMNNKMNLQSKQSLSQDPAVKVQEIQTKTKELYSACN 781

  Fly   846 YLVNKIKIWKPKVKPAAEKEKKKEEEVVASGSGDDTKSEDAEQQQEQATKEEQQEQEPVDEITPT 910
            .:|.|.   ||||:|       .:||..|..:|.....:.::.|.|:                 :
Zfish   782 PVVTKS---KPKVEP-------PKEETAAEQNGPVNGQQPSDAQPEK-----------------S 819

  Fly   911 PAEEETKTPHSEL 923
            |...|.|.|..::
Zfish   820 PENTEAKLPEMDI 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	171/620 (28%)
		HYOU1-like_NBD	23..409	CDD:212672	121/393 (31%)
		TAF4	<572..>627	CDD:296797	12/54 (22%)
hspa4a	NP_999881.1	NBD_sugar-kinase_HSP70_actin	2..384	CDD:302596	123/398 (31%)
hspa4a	NP_999881.1	HSP70	3..692	CDD:278441	206/749 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810