Protein Alignment CG2918 and HSPA9

DIOPT Version :9

• Sequence 1: NP_001162645.1
• Gene: CG2918 / 31215
• FlyBaseID: FBgn0023529
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_004125.3
• Gene: HSPA9 / 3313
• HGNCID: 5244
• Length: 679
• Species: Homo sapiens
• Alignment Length: 794
• Identity: 190/794 - (23%)
• Similarity: 309/794 - (38%)
• Gaps: 224/794 - (28%)

  Fly     8 SALLAGIALSQG--------------------------------AAVMSVDLGSEWMKVGVVSPG 40
            :|.|.|.|.|:|                                .||:.:|||:....|.|:. |
Human     9 AARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVME-G 72

  Fly    41 VPMEIALNRESKRKTPAILAF-RDGTRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYR 104
            ...::..|.|..|.||:::|| .||.|.:|..|:...:.:||:.:.....|:|:..|:|.|....
Human    73 KQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDI 137

  Fly   105 KRFPYYNIVGDPERNTVVFRKSDTDE--------FSVEELVAQLLVKAKQFAQESVQQPITECVL 161
            |..|:           .:.|.|:.|.        :|..::.|.:|:|.|:.|:..:.......|:
Human   138 KNVPF-----------KIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVI 191

  Fly   162 TVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINETAQYFLFYDMGAYKTS 226
            |||.||..::|:|...|.|::.|.||::||:..|.||.||: .:.|....|    .||:|.....
Human   192 TVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGL-DKSEDKVIA----VYDLGGGTFD 251

  Fly   227 AAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALKKTKTDVTTSPRA 291
            .:::..|          ..|.:|.....|..|||.:....|..::.:||.  ::|..|:|....|
Human   252 ISILEIQ----------KGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFK--RETGVDLTKDNMA 304

  Fly   292 LAKLFKEAGRLKNVLSANTEFFAQIENLIED------IDFKLPVTREKLEQLCEDLWPRATKPLE 350
            |.::.:.|.:.|..||::.:....:..|..|      ::.||  ||.:.|.:..||..|...|.:
Human   305 LQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKL--TRAQFEGIVTDLIRRTIAPCQ 367

  Fly   351 EALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESATMGAVYKAADLSAGF 415
            :|:..:.:|...|.:|||.||.||:|:||:|::.:..:...|.:|.||:..:||..:...|:.
Human   368 KAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAG-- 430

  Fly   416 KVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFNKHTDDFEFYVNYA 480
            .|...::.|.|  ||.:..|  ...|...|.:.|     ....|.||...|:...|
Human   431 DVTDVLLLDVT--PLSLGIE--TLGGVFTKLINR-----NTTIPTKKSQVFSTAAD--------- 477

  Fly   481 DLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELV-DNK------------------GIKAY 526
                            ..|:|::|     :.:.::|:. |||                  .|:..
Human   478 ----------------GQTQVEIK-----VCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVT 521

  Fly   527 FYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGE 591
            |.:|.:||        |:...|.:....|...:.:....||          ||:.|
Human   522 FDIDANGI--------VHVSAKDKGTGREQQIVIQSSGGLS----------KDDIE--------- 559

  Fly   592 EPSKSEDNEKAKEEDASKEQKSE-----ESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVG 651
              :..::.||..|||..|:::.|     |....|||.|.|..|
Human   560 --NMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFK---------------------- 600

  Fly   652 SAYDQSVA----KL-AAINKAEEQRVRLES--------AFNALEAHIIEVQQKLDEESYAKCA-- 701
               ||..|    || ..|:|..|...|.:|        |.::|:    :...||.|.:|.|.|
Human   601 ---DQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQ----QASLKLFEMAYKKMASE 658

  Fly   702 --------TAEEKE 707
                    |.|:||
Human   659 REGSGSSGTGEQKE 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	158/641 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	111/400 (28%)
		TAF4	<572..>627	CDD:296797	15/59 (25%)
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583	1..432		120/455 (26%)
		dnaK	52..673	CDD:234715	184/751 (25%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583	432..679		70/338 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		5/17 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900