DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and HSPA6

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_002146.2	Gene:	HSPA6 / 3310	HGNCID:	5239	Length:	643	Species:	Homo sapiens

Alignment Length:	739	Identity:	190/739 - (25%)
Similarity:	315/739 - (42%)	Gaps:	148/739 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 MSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYGYL 87
            :.:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.:|:.|::....:|::.....
Human     9 VGIDLGTTYSCVGVFQQG-RVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPHNTVFDA 72

  Fly    88 LDLLGKTIDNPIVDLYRKRFPYYNIV--GDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQFAQE 150
            ..|:|:...:..|....|.:| :.:|  |...:..|.:|..| ..|..||:.:.:|.|.|:.|:.
Human    73 KRLIGRKFADTTVQSDMKHWP-FRVVSEGGKPKVRVCYRGED-KTFYPEEISSMVLSKMKETAEA 135

  Fly   151 SVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHR--GEINETAQ 213
            .:.||:...|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||:..|  ||.|
Human   136 YLGQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERN---- 196

  Fly   214 YFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNAL 278
             .|.:|:|......:|:|...          .|.:|.....|..|||.:...||.::..:||.
Human   197 -VLIFDLGGGTFDVSVLSIDA----------GVFEVKATAGDTHLGGEDFDNRLVNHFMEEFR-- 248

  Fly   279 KKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWP 343
            :|...|::.:.|||.:|.....|.|..||::|:...:|::|.|.:||...:||.:.|:||.||:.
Human   249 RKHGKDLSGNKRALRRLRTACERAKRTLSSSTQATLEIDSLFEGVDFYTSITRARFEELCSDLFR 313

  Fly   344 RATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATMGAVYK 407
            ...:|:|:||..:.|....|:.|:|.||.||:|:||:.::.... :||.|::|.||:...||..:
Human   314 STLEPVEKALRDAKLDKAQIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQ 378

  Fly   408 AADLSAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFNKH 469
            ||.| .|.|.:|  |:|..|.   ||.:..|...|       |...|.......|.|:..||..:
Human   379 AAVL-MGDKCEK--VQDLLLLDVAPLSLGLETAGG-------VMTTLIQRNATIPTKQTQTFTTY 433

  Fly   470 TDDFE-FYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKG---IKAYFYLD 530
            :|:.. .::...:.:|...::...||...::.:....               :|   |:..|.:|
Human   434 SDNQPGVFIQVYEGERAMTKDNNLLGRFELSGIPPAP---------------RGVPQIEVTFDID 483

  Fly   531 DSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPSK 595
            .:||...|..:....|.......::...|||          :|.|.....:||          .|
Human   484 ANGILSVTATDRSTGKANKITITNDKGRLSK----------EEVERMVHEAEQ----------YK 528

  Fly   596 SEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAK 660
            :||
Human   529 AED-------------------------------------------------------------- 531

  Fly   661 LAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDLE 725
                   |.||.|: :|.|:||||:..|:..|.|||.......|::.|:..:|..:..|| |..:
Human   532 -------EAQRDRV-AAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWL-EHNQ 587

  Fly   726 DPKAEIYEEKLAQLKKLSNVFLAR 749
            ..:.|.||.:..:|:::.....:|
Human   588 LAEKEEYEHQKRELEQICRPIFSR 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	164/613 (27%)
		HYOU1-like_NBD	23..409	CDD:212672	123/390 (32%)
		TAF4	<572..>627	CDD:296797	7/54 (13%)
HSPA6	NP_002146.2	Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	3..388		128/399 (32%)
		HSP70	8..643	CDD:331774	190/739 (26%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	396..511		22/136 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..643
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810