back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and HSPA5

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_005338.1	Gene:	HSPA5 / 3309	HGNCID:	5238	Length:	654	Species:	Homo sapiens

Alignment Length:	800	Identity:	197/800 - (24%)
Similarity:	330/800 - (41%)	Gaps:	177/800 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLVLLLSALLAGIALSQGAA-----------VMSVDLGSEWMKVGVVSPGVPMEIALNRESKRK 54
            |||.|:.:.||   .||...|           |:.:|||:.:..|||...| .:||..|.:..|.
Human     1 MKLSLVAAMLL---LLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNG-RVEIIANDQGNRI 61

  Fly    55 TPAILAFR-DGTRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPER 118
            ||:.:||. :|.|.||:.|:.....:|.:.......|:|:|.::|.|....|..|:..:    |:
Human    62 TPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV----EK 122

  Fly   119 NTVVFRKSD-----TDEFSVEELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSA 178
            .|..:.:.|     |..|:.||:.|.:|.|.|:.|:..:.:.:|..|:|||.||..|:|:|...|
Human   123 KTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDA 187

  Fly   179 AQLANLKVLQLINDYAAVALNYGVFHR-GEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTRE 242
            ..:|.|.|:::||:..|.|:.||:..| ||.|     .|.:|:|......::::..
Human   188 GTIAGLNVMRIINEPTAAAIAYGLDKREGEKN-----ILVFDLGGGTFDVSLLTID--------- 238

  Fly   243 INPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLS 307
             |.|.:|:....|..|||.:...|:.::..:.:.  |||..||....||:.||.:|..:.|..||
Human   239 -NGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYK--KKTGKDVRKDNRAVQKLRREVEKAKRALS 300

  Fly   308 ANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGG 372
            :..:...:||:..|..||...:||.|.|:|..||:....||:::.|..|.|....|::::|.||.
Human   301 SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGS 365

  Fly   373 TRVPRVQETIKAVIK-QELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFER 436
            ||:|::|:.:|.... :|..:.:|.||:...||..:|..||........|:.|  :.||.:..|
Human   366 TRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLD--VCPLTLGIE- 427

  Fly   437 DPGDGAAVKQVKRALFALMNPYPQKKVITF-----NKHTDDFEFYVNYADLDRYSKEEIAALGSL 496
                  .|..|...|.......|.||...|     |:.|...:.|    :.:|...::...||:.
Human   428 ------TVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVY----EGERPLTKDNHLLGTF 482

  Fly   497 NVTKVQLKQVKELLEKSKKELVDNKG---IKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDST 558
            ::|.:....               :|   |:..|.:|.:||.|.|              |::..|
Human   483 DLTGIPPAP---------------RGVPQIEVTFEIDVNGILRVT--------------AEDKGT 518

  Fly   559 LSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEA 623
            .:|     :|:.....:.:....|.|...|         |.||..|||        :..|:..:.
Human   519 GNK-----NKITITNDQNRLTPEEIERMVN---------DAEKFAEED--------KKLKERIDT 561

  Fly   624 KNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEV 688
            :||                                                      ||::...:
Human   562 RNE------------------------------------------------------LESYAYSL 572

  Fly   689 QQKL-DEESYAKCATAEEKEKLLAECSTLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            :.:: |:|......::|:||.:........||| |..:|...|.::.|..:|:::....:::.:.
Human   573 KNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWL-ESHQDADIEDFKAKKKELEEIVQPIISKLYG 636

  Fly   753 HEERPEAIKALKGMIDGAEK 772
            ....|..     |..|.|||
Human   637 SAGPPPT-----GEEDTAEK 651

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.