DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and HSPA4

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_002145.3	Gene:	HSPA4 / 3308	HGNCID:	5237	Length:	840	Species:	Homo sapiens

Alignment Length:	928	Identity:	248/928 - (26%)
Similarity:	427/928 - (46%)	Gaps:	115/928 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYG 85
            :|:.:|||.:...|.|...| .:|...|..|.|.|||.::|....|:||..|::..|.:..:...
Human     2 SVVGIDLGFQSCYVAVARAG-GIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNAKNTVQ 65

  Fly    86 YLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNT---VVFRKSDTDEFSVEELVAQLLVKAKQF 147
            ......|:...:|.|:..:.... |:||..|...|   |.:.:.:.: |:.|::.|.||.|.|:.
Human    66 GFKRFHGRAFSDPFVEAEKSNLA-YDIVQLPTGLTGIKVTYMEEERN-FTTEQVTAMLLSKLKET 128

  Fly   148 AQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRG--EINE 210
            |:..:::|:.:||::||.::..|||.:::.|.|:|.|..|:|:|:..||||.||::.:.  .:.|
Human   129 AESVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEE 193

  Fly   211 TAQYFLFYDMG--AYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQ 273
            ..:..:|.|||  ||:.|....:...:|            ||...:|.||||.:....|.::..:
Human   194 KPRNVVFVDMGHSAYQVSVCAFNRGKLK------------VLATAFDTTLGGRKFDEVLVNHFCE 246

  Fly   274 EFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSAN-TEFFAQIENLIEDIDFKLPVTREKLEQL 337
            ||.  ||.|.|:.:..|||.:|.:|..:||.::||| ::....||..:.|:|....:.|.|..::
Human   247 EFG--KKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEM 309

  Fly   338 CEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESATM 402
            |.||..|...||...|..:.|..:.|..|.:.||.||:|.|:|.|.....:||...|||||:.|.
Human   310 CNDLLARVEPPLRSVLEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTR 374

  Fly   403 GAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITF- 466
            |...:.|.||..|||::|.:.|...:|:.:.:.....:|::..:|    |:..:..|..||:||
Human   375 GCALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEV----FSKNHAAPFSKVLTFY 435

  Fly   467 NKHTDDFEFYVN------YAD--LDRYSKEEIAALGSLNVTKVQLK---QVKELLEKSKKELVDN 520
            .|.....|.|.:      |.|  :.::|.:::......:.:||::|   .|..:...|...||:
Human   436 RKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVE- 499

  Fly   521 KGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEE 585
                                  |::.::.|:..:.|....              ||:|...:|||
Human   500 ----------------------VHKSEENEEPMETDQNAK--------------EEEKMQVDQEE 528

  Fly   586 AANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQD--TEAKNETIKLVTVKSPVTYESQTQFVVP 648
             .:..|:..::....||:.|:....|...:..|.|  .:||...:|..||..|:..:...|....
Human   529 -PHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLPIENQLLWQIDRE 592

  Fly   649 LVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAEC 713
            :: :.|.::..|:...:|.|::|   ..|.||:|.::.|::.||..| |.|..:.:::.....:.
Human   593 ML-NLYIENEGKMIMQDKLEKER---NDAKNAVEEYVYEMRDKLSGE-YEKFVSEDDRNSFTLKL 652

  Fly   714 STLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVTGR 778
            .....|||||.||...::|.:|||:||.|......|..|.||||:..:.|...|....|.:.:.:
Human   653 EDTENWLYEDGEDQPKQVYVDKLAELKNLGQPIKIRFQESEERPKLFEELGKQIQQYMKIISSFK 717

  Fly   779 NLTKDTNPEKDVFTQVEIDTLDKVITETN---AWLKTETAAQKKLAKNADIRLTVKDITDKMSLL 840
            |       ::|.:..::...:.||...||   .|:..:...|.|.:...|..:..|:|..|:..|
Human   718 N-------KEDQYDHLDAADMTKVEKSTNEAMEWMNNKLNLQNKQSLTMDPVVKSKEIEAKIKEL 775

  Fly   841 DREVKYLVNKIKIWKPKVKPAAEKEKKKEEEVVASGSGDDTKSEDAEQQQEQATKEEQQEQEPVD 905
            ......:::|.   ||||:|..|::|..|:.....|.||:...:.|||..:
Human   776 TSTCSPIISKP---KPKVEPPKEEQKNAEQNGPVDGQGDNPGPQAAEQGTD-------------- 823

  Fly   906 EITPTPAEEETKTPHSEL 923
              |..|::.:.|.|..::
Human   824 --TAVPSDSDKKLPEMDI 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	171/624 (27%)
		HYOU1-like_NBD	23..409	CDD:212672	123/393 (31%)
		TAF4	<572..>627	CDD:296797	15/56 (27%)
HSPA4	NP_002145.3	HSPA4_NBD	2..384	CDD:212687	125/398 (31%)
		HSP70	3..607	CDD:278441	179/663 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..575		19/89 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..840		19/80 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810