DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and HSPA2

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001374860.1	Gene:	HSPA2 / 3306	HGNCID:	5235	Length:	639	Species:	Homo sapiens

Alignment Length:	748	Identity:	178/748 - (23%)
Similarity:	323/748 - (43%)	Gaps:	147/748 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPN 81
            ::|.|: .:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|.
Human     3 ARGPAI-GIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPT 65

  Fly    82 SAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQ 146
            :.......|:|:..::..|....|.:|:..:....:....|..|.:|..|..||:.:.:|.|.|:
Human    66 NTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKE 130

  Fly   147 FAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHR----GE 207
            .|:..:...:...|:|||.||..::|:|...|..:..|.||::||:..|.|:.||:..:    ||
Human   131 IAEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGE 195

  Fly   208 INETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLA 272
            .|     .|.:|:|......::::.:          :.:.:|.....|..|||.:...|:..:||
Human   196 KN-----VLIFDLGGGTFDVSILTIE----------DGIFEVKSTAGDTHLGGEDFDNRMVSHLA 245

  Fly   273 QEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQL 337
            :||.  :|.|.|:..:.||:.:|.....|.|..||::|:...:|::|.|.:||...:||.:.|:|
Human   246 EEFK--RKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEEL 308

  Fly   338 CEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESAT 401
            ..||:....:|:|:||..:.|....|.:::|.||.||:|::|:.::.... :||.|::|.||:..
Human   309 NADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVA 373

  Fly   402 MGAVYKAADLSAGFK---VKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKV 463
            .||..:||.| .|.|   |:..::.|.|  ||.:..|  ...|.....:||     ....|.|:.
Human   374 YGAAVQAAIL-IGDKSENVQDLLLLDVT--PLSLGIE--TAGGVMTPLIKR-----NTTIPTKQT 428

  Fly   464 ITFNKHTDD-FEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKG---IK 524
            .||..::|: ....|...:.:|...::...||..::|.:....               :|   |:
Human   429 QTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAP---------------RGVPQIE 478

  Fly   525 AYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANA 589
            ..|.:|.:||...|              |.:.||               |:|.|
Human   479 VTFDIDANGILNVT--------------AADKST---------------GKENK----------- 503

  Fly   590 GEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAY 654
               .:.:.|..:..::|..:..:..|..|.:.||..:.:
Human   504 ---ITITNDKGRLSKDDIDRMVQEAERYKSEDEANRDRV-------------------------- 539

  Fly   655 DQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEW 719
                                 :|.||||::...::|.:::|......:.::|.|:|.:|..:..|
Human   540 ---------------------AAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINW 583

  Fly   720 LYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            |..:....|.| ||.|..:|:::.|..:::.::
Human   584 LDRNQMAEKDE-YEHKQKELERVCNPIISKLYQ 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	156/614 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	113/390 (29%)
		TAF4	<572..>627	CDD:296797	9/54 (17%)
HSPA2	NP_001374860.1	PTZ00009	2..615	CDD:240227	178/746 (24%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..389		120/405 (30%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	397..512		32/181 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..639		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810