Protein Alignment Grp170 and HSPA2

DIOPT Version :10

• Sequence 1: NP_569995.1
• Gene: Grp170 / 31215
• FlyBaseID: FBgn0023529
• Length: 923
• Species: Drosophila melanogaster
• Sequence 2: NP_068814.2
• Gene: HSPA2 / 3306
• HGNCID: 5235
• Length: 639
• Species: Homo sapiens
• Alignment Length: 747
• Identity: 178/747 - (23%)
• Similarity: 324/747 - (43%)
• Gaps: 145/747 - (19%)

  Fly    17 SQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPN 81
            ::|.|: .:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|.
Human     3 ARGPAI-GIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPT 65

  Fly    82 SAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQ 146
            :.......|:|:..::..|....|.:|:..:....:....|..|.:|..|..||:.:.:|.|.|:
Human    66 NTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKE 130

  Fly   147 FAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHR----GE 207
            .|:..:...:...|:|||.||..::|:|...|..:..|.||::||:..|.|:.||:..:    ||
Human   131 IAEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGE 195

  Fly   208 INETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLA 272
            .|     .|.:|:|......::::.:          :.:.:|.....|..|||.:...|:..:||
Human   196 KN-----VLIFDLGGGTFDVSILTIE----------DGIFEVKSTAGDTHLGGEDFDNRMVSHLA 245

  Fly   273 QEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQL 337
            :||.  :|.|.|:..:.||:.:|.....|.|..||::|:...:|::|.|.:||...:||.:.|:|
Human   246 EEFK--RKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEEL 308

  Fly   338 CEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESAT 401
            ..||:....:|:|:||..:.|....|.:::|.||.||:|::|:.::.... :||.|::|.||:..
Human   309 NADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVA 373

  Fly   402 MGAVYKAADLSAGFK---VKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKV 463
            .||..:||.| .|.|   |:..::.|.|  ||.:..|  ...|.....:||     ....|.|:.
Human   374 YGAAVQAAIL-IGDKSENVQDLLLLDVT--PLSLGIE--TAGGVMTPLIKR-----NTTIPTKQT 428

  Fly   464 ITFNKHTDD-FEFYVNYADLDRYSKEEIAALGSLNVTKV--QLKQVKELLEKSKKELVDNKGIKA 525
            .||..::|: ....|...:.:|...::...||..::|.:  ..:.|.:              |:.
Human   429 QTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQ--------------IEV 479

  Fly   526 YFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAG 590
            .|.:|.:||...|              |.:.||               |:|.|
Human   480 TFDIDANGILNVT--------------AADKST---------------GKENK------------ 503

  Fly   591 EEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYD 655
              .:.:.|..:..::|..:..:..|..|.:.||..:.:
Human   504 --ITITNDKGRLSKDDIDRMVQEAERYKSEDEANRDRV--------------------------- 539

  Fly   656 QSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWL 720
                                :|.||||::...::|.:::|......:.::|.|:|.:|..:..||
Human   540 --------------------AAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWL 584

  Fly   721 YEDLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            ..:....|.| ||.|..:|:::.|..:::.::
Human   585 DRNQMAEKDE-YEHKQKELERVCNPIISKLYQ 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grp170	NP_569995.1	ASKHA_NBD_HSP70_HYOU1	21..409	CDD:466828	114/392 (29%)
		PTZ00121	<546..917	CDD:173412	32/207 (15%)
		TAF4	<572..>627	CDD:461598	9/54 (17%)
HSPA2	NP_068814.2	PTZ00009	2..615	CDD:240227	178/745 (24%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		120/405 (30%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		32/180 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..639		0/3 (0%)