DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2918 and HSPA1L

DIOPT Version :9

Sequence 1:NP_001162645.1 Gene:CG2918 / 31215 FlyBaseID:FBgn0023529 Length:923 Species:Drosophila melanogaster
Sequence 2:NP_005518.3 Gene:HSPA1L / 3305 HGNCID:5234 Length:641 Species:Homo sapiens


Alignment Length:753 Identity:186/753 - (24%)
Similarity:327/753 - (43%) Gaps:153/753 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IALSQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIK 78
            :|.::|.|: .:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....
Human     1 MATAKGIAI-GIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAM 63

  Fly    79 DPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVK 143
            :|.:.......|:|:..::|:|....|.:|:..|....:...:|..|.:...|..||:.:.:|.|
Human    64 NPQNTVFDAKRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTK 128

  Fly   144 AKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEI 208
            .|:.|:..:..|:|..|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||:...|  
Human   129 LKETAEAFLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGG-- 191

  Fly   209 NETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQ 273
             :..::.|.:|:|......::::..          :.:.:|.....|..|||.:...||..:..:
Human   192 -QGERHVLIFDLGGGTFDVSILTID----------DGIFEVKATAGDTHLGGEDFDNRLVSHFVE 245

  Fly   274 EFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLC 338
            ||.  :|.|.|::.:.||:.:|.....|.|..||::|:...:|::|.|.|||...:||.:.|:||
Human   246 EFK--RKHKKDISQNKRAVRRLRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELC 308

  Fly   339 EDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATM 402
            .||:....:|:|:||..:.:....|:.::|.||.||:|:||..::.... ::|.|::|.||:...
Human   309 ADLFRGTLEPVEKALRDAKMDKAKIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAY 373

  Fly   403 GAVYKAADLSAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVI 464
            ||..:||.| .|.|.:|  |:|..|.   ||.:..|...|       |..||....:..|.|:..
Human   374 GAAVQAAIL-MGDKSEK--VQDLLLLDVAPLSLGLETAGG-------VMTALIKRNSTIPTKQTQ 428

  Fly   465 TFNKHTDD-----FEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKG-- 522
            .|..::|:     .:.|    :.:|...::...||..::|.:....               :|  
Human   429 IFTTYSDNQPGVLIQVY----EGERAMTKDNNLLGRFDLTGIPPAP---------------RGVP 474

  Fly   523 -IKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDST--LSKFGSTLSKLFTKEGEEKKDNSEQE 584
             |:..|.:|.:||...|              |.:.||  ::|...|..|     |...|:..|:.
Human   475 QIEVTFDIDANGILNVT--------------ATDKSTGKVNKITITNDK-----GRLSKEEIERM 520

  Fly   585 EAANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPL 649
            ..           |.||.|.||                                           
Human   521 VL-----------DAEKYKAED------------------------------------------- 531

  Fly   650 VGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECS 714
                              |.||.:: :|.||||::...::..:.:|......:..:|.|:|.:|:
Human   532 ------------------EVQREKI-AAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCN 577

  Fly   715 TLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            .|..||..:....|.| ::.|..:|:::.|..:.:.::
Human   578 ELLSWLEVNQLAEKDE-FDHKRKELEQMCNPIITKLYQ 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2918NP_001162645.1 HSP70 22..625 CDD:278441 162/616 (26%)
HYOU1-like_NBD 23..409 CDD:212672 115/386 (30%)
TAF4 <572..>627 CDD:296797 9/54 (17%)
HSPA1LNP_005518.3 Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 3..388 122/402 (30%)
HSP70 4..641 CDD:331774 185/750 (25%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 396..511 29/159 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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