DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and HSPA1B

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_005337.2	Gene:	HSPA1B / 3304	HGNCID:	5233	Length:	641	Species:	Homo sapiens

Alignment Length:	745	Identity:	186/745 - (24%)
Similarity:	323/745 - (43%)	Gaps:	156/745 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAY 84
            ||.:.:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|.:..
Human     4 AAAIGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTV 67

  Fly    85 GYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTV-VFRKSDTDEFSVEELVAQLLVKAKQFA 148
            .....|:|:...:|:|....|.:| :.::.|.::..| |..|.:|..|..||:.:.:|.|.|:.|
Human    68 FDAKRLIGRKFGDPVVQSDMKHWP-FQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIA 131

  Fly   149 QESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFH--RGEINET 211
            :..:..|:|..|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||:..  :||.|
Human   132 EAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERN-- 194

  Fly   212 AQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFN 276
               .|.:|:|......::::..          :.:.:|.....|..|||.:...||.::..:||.
Human   195 ---VLIFDLGGGTFDVSILTID----------DGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFK 246

  Fly   277 ALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDL 341
              :|.|.|::.:.||:.:|.....|.|..||::|:...:|::|.|.|||...:||.:.|:||.||
Human   247 --RKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDL 309

  Fly   342 WPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATMGAV 405
            :....:|:|:||..:.|....|:.::|.||.||:|:||:.::.... ::|.|::|.||:...||.
Human   310 FRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAA 374

  Fly   406 YKAADLSAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFN 467
            .:||.|...   |...|:|..|.   ||.:..|...|       |..||....:..|.|:...|.
Human   375 VQAAILMGD---KSENVQDLLLLDVAPLSLGLETAGG-------VMTALIKRNSTIPTKQTQIFT 429

  Fly   468 KHTDD-----FEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKG---IK 524
            .::|:     .:.|    :.:|...::...||...::.:....               :|   |:
Human   430 TYSDNQPGVLIQVY----EGERAMTKDNNLLGRFELSGIPPAP---------------RGVPQIE 475

  Fly   525 AYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANA 589
            ..|.:|.:||...|              |.:.||               |:..|.....::...:
Human   476 VTFDIDANGILNVT--------------ATDKST---------------GKANKITITNDKGRLS 511

  Fly   590 GEEPSKS-EDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSA 653
            .||..:. ::.||.|.||
Human   512 KEEIERMVQEAEKYKAED----------------------------------------------- 529

  Fly   654 YDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGE 718
                          |.||.|: ||.||||::...::..:::|......:..:|:|:|.:|..:..
Human   530 --------------EVQRERV-SAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVIS 579

  Fly   719 WLYEDLEDPKAEIYEEKLAQLKKLSNVFLA 748
            ||..:....|.| :|.|..:|:::.|..::
Human   580 WLDANTLAEKDE-FEHKRKELEQVCNPIIS 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	161/618 (26%)
		HYOU1-like_NBD	23..409	CDD:212672	120/389 (31%)
		TAF4	<572..>627	CDD:296797	9/55 (16%)
HSPA1B	NP_005337.2	PTZ00009	1..611	CDD:240227	186/745 (25%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		126/403 (31%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		27/169 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..641
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810