DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and hyou1

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_997868.1	Gene:	hyou1 / 327133	ZFINID:	ZDB-GENE-030131-5344	Length:	980	Species:	Danio rerio

Alignment Length:	965	Identity:	414/965 - (42%)
Similarity:	577/965 - (59%)	Gaps:	72/965 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPN 81
            ::..||||||||||||||.:|.|||||||.||:||:||||..:..::..|..|:.|..:.:|:|.
Zfish    22 TESVAVMSVDLGSEWMKVAIVKPGVPMEIVLNKESRRKTPVAVCLKENERLFGDGALGVAVKNPK 86

  Fly    82 SAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQ 146
            ..|.:|..:||||.|||.|..|:|.||.:.:..|.:|.||.|:.|:..:::.|||:..:|..::.
Zfish    87 VVYRFLQSILGKTADNPQVAEYQKHFPEHQLQKDEKRGTVYFKFSEEMQYTPEELLGMILNYSRT 151

  Fly   147 FAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINET 211
            .||:..:|||.:.|:|||.||.||||.|:|.||.:|.|||||||||..|||||||||.|.:||.|
Zfish   152 LAQDFAEQPIKDAVITVPAYFNQAERRAVLQAAHIAGLKVLQLINDNTAVALNYGVFRRKDINST 216

  Fly   212 AQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFN 276
            ||..:|||||:..|:|.:|:||.||.|:: ...|.:|:.|||:||||||.|::|||||:||:.||
Zfish   217 AQNIMFYDMGSGSTTATIVTYQTVKTKES-GTQPQLQIRGVGFDRTLGGFEMELRLRDHLAKLFN 280

  Fly   277 ALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDL 341
            ..||:|.||..:.||:|||.|||.|||.|||||.|..||||.|::|||||..|||.:.|.|||||
Zfish   281 EQKKSKKDVRDNLRAMAKLLKEAQRLKTVLSANAEHTAQIEGLMDDIDFKAKVTRSEFEALCEDL 345

  Fly   342 WPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQET-IKAVIKQELGKNLNADESATMGAV 405
            :.|...|:::|||::.:|:|.|.||||.||.||||:||:. :|:|.|:||.||:||||:|.||||
Zfish   346 FDRVPGPVKQALAAAEMSMDEIEQVILVGGATRVPKVQDVLLKSVGKEELSKNINADEAAAMGAV 410

  Fly   406 YKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQV---KRALFALMNPYPQKKVITFN 467
            |:||.||..||||.|:|:||.:||:||.|.|:..:...||.:   ||.||..|.||||:||||||
Zfish   411 YQAAALSKAFKVKPFLVRDAAVFPIQVEFSRETEEEDGVKSLKHNKRILFQRMAPYPQRKVITFN 475

  Fly   468 KHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKGIKAYFYLDDS 532
            ::.|||.||:||.||...|::::...||.|:|.|:|..|....:|...  .::|||||:|.:|:|
Zfish   476 RYIDDFVFYINYGDLSFLSEQDMKVFGSQNLTTVKLSGVGSSFKKHSD--AESKGIKAHFNMDES 538

  Fly   533 GIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLF---------------TKEGE------- 575
            |:.....||.|:|  ...::.:|:|||:|.|:|:|.||               |.|.|
Zfish   539 GVLILDRVESVFE--TIVEEKEEESTLTKLGNTISSLFGGGSSEPSANVTEPVTDEEEVTPEAGK 601

  Fly   576 -------------EKKDNSEQEEAANAGEEPSKSEDNEKAK---EEDASKEQKSEEST---KQDT 621
                         ||.:..|.:||....||  :.||.|||:   |.::.|.:|.||.|   :::.
Zfish   602 EQDQPEKQEETVQEKPETEEGKEAEPQAEE--QKEDKEKAENQGETESEKTEKPEEKTTDEEKEA 664

  Fly   622 EAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHII 686
            :.|.:..|...:.:.:..|.:...|:.......:.|..||..:...:.::...|...|:|||.|.
Zfish   665 DMKPKLQKKSKISADIAVELEVNDVLDPSAEDMEGSKKKLQDLTDRDLEKQEREKTLNSLEAFIF 729

  Fly   687 EVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHW 751
            |.|.||.::.|....|.||||::....|....|:.|:......::.:|||::||||......|..
Zfish   730 ETQDKLYQDEYQAVVTEEEKEQISGRLSVASSWMDEEGYRAGTKLLKEKLSELKKLCKGMFFRVE 794

  Fly   752 EHEERPEAIKALKGMIDGAEKFLVTGRNLTKDTNPEKD-VFTQVEIDTLDKVITETNAWLKTETA 815
            |.::.|:.:.||..|::.:..||.:.|.:     ||.| :||.||:.||:|||.||..|.....|
Zfish   795 ERKKWPDRLAALDSMLNHSNIFLKSARLI-----PESDQIFTDVELKTLEKVINETITWKNETVA 854

  Fly   816 AQKKLAKNADIRLTVKDITDKMSLLDREVKYLVNKIKIWKPKVKPAAEKEKKKEEEVVASGSGDD 880
            .|:||:......|..|||..|:|||||||.||:||.|..|||.|..| |:|....|...:.|.||
Zfish   855 EQEKLSPTVKPVLLSKDIEAKLSLLDREVNYLLNKAKFAKPKPKDKA-KDKNSTSESSKANSTDD 918

  Fly   881 TKSEDAEQQQEQATKEEQQEQEPVDE-------ITPTPAE------EETKTPHSE 922
            .:.....:.::.|.|.:..|:.||.|       :...|||      |.|::..||
Zfish   919 AEKVIPPKTEDGAEKVKPAEEPPVVEEKAEETILELNPAENTDDKTESTESSKSE 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	311/647 (48%)
		HYOU1-like_NBD	23..409	CDD:212672	213/386 (55%)
		TAF4	<572..>627	CDD:296797	21/80 (26%)
hyou1	NP_997868.1	HSP70	27..705	CDD:278441	317/684 (46%)
		HYOU1-like_NBD	28..414	CDD:212672	213/386 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..682		33/125 (26%)
		PTPRCAP	<598..>648	CDD:292341	13/51 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..980		24/81 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255	977..980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575205
Domainoid	1	1.000	565	1.000	Domainoid score	I229
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4658
Inparanoid	1	1.050	695	1.000	Inparanoid score	I661
OMA	1	1.010	-	-		QHG54551
OrthoDB	1	1.010	-	-		D125779at33208
OrthoFinder	1	1.000	-	-		FOG0003505
OrthoInspector	1	1.000	-	-		oto41342
orthoMCL	1	0.900	-	-		OOG6_101811
Panther	1	1.100	-	-	LDO	PTHR45639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3997
SonicParanoid	1	1.000	-	-		X2877
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800