DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and Hsph1

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001011901.1	Gene:	Hsph1 / 288444	RGDID:	1311609	Length:	858	Species:	Rattus norvegicus

Alignment Length:	914	Identity:	257/914 - (28%)
Similarity:	421/914 - (46%)	Gaps:	118/914 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYG 85
            :|:.:|:||:...:.|...| .:|...|..|.|.||::::|....||||..|:...|...|:...
  Rat     2 SVVGLDVGSQSCYIAVARAG-GIETIANEFSDRCTPSVISFGPKNRTIGVAAKNQQITHANNTVS 65

  Fly    86 YLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRK---SDTDE-FSVEELVAQLLVKAKQ 146
            ......|:..::|.:...::... |::|  |.:|..|..|   .|.|. ||||::.|.||.|.|:
  Rat    66 SFKRFHGRAFNDPFIQKEKENLS-YDLV--PMKNGGVGIKVMYMDEDHLFSVEQITAMLLTKLKE 127

  Fly   147 FAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRG--EIN 209
            .|:.::::|:|:||::||.:|..|||.::|.|||:..|..|:|:||..|||||||::.:.  ..:
  Rat   128 TAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNAD 192

  Fly   210 ETAQYFLFYDMG--AYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLA 272
            |..:..:|.|||  :::.||...:    |.|        ::|||..:|..|||.....:|.::..
  Rat   193 EKPRVVVFVDMGHSSFQVSACAFN----KGK--------LKVLGTAFDPFLGGKNFDEKLVEHFC 245

  Fly   273 QEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSAN-TEFFAQIENLIEDIDFKLPVTREKLEQ 336
            .||..  |.|.|..:..|||.:|.:|..:||.::|:| |:....||..:.|.|....:.|.:.|:
  Rat   246 AEFKT--KYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSAKMNRSQFEE 308

  Fly   337 LCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESAT 401
            ||.:|..:...||...:..:||..:.::.:.:.||.||:|.|:|.|.....:::...|||||:..
  Rat   309 LCAELLQKIEVPLHLLMEQTHLKTEEVSAIEIVGGATRIPAVKERIARFFGKDVSTTLNADEAVA 373

  Fly   402 MGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITF 466
            .|...:.|.||..|||::|.|.||..||:.:.:..|..:...|.:|    |:..:..|..||:||
  Rat   374 RGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEGVHEV----FSRNHAAPFSKVLTF 434

  Fly   467 NKHTDDFEFYVNYAD----------LDRYSKEEIAALGSLNVTKVQLK-----------QVKELL 510
            .:. ..||....|:|          :.|:..:.::|......:||::|           ....::
  Rat   435 LRR-GPFELEAFYSDPQAVPYPEAKIGRFVVQNVSAQKDGEKSKVKVKVRVNTHGIFTISTASMV 498

  Fly   511 EKSKKELVDNKGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGE 575
            ||...|..|...::|               :.....|||.:.:|.|..:
  Rat   499 EKVPTEEEDGSSVEA---------------DMECPNQKPAESSDVDKNI---------------- 532

  Fly   576 EKKDNSEQEEAANAGEEPSKSEDNEKAKEEDASKEQKSEES------------TKQDTEAKNETI 628
             ::||||      ||.:|....|.::..:...|.|..|||:            ..|..|||...|
  Rat   533 -QQDNSE------AGTQPQVQTDGQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKI 590

  Fly   629 KLVTVKSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLD 693
            |:|.|:.||......|....|: :.|.::..|:...:|.|::|   ..|.||:|..:.|.:.||.
  Rat   591 KVVNVELPVEANLVWQLGRDLL-NMYIETEGKMIMQDKLEKER---NDAKNAVEECVYEFRDKLC 651

  Fly   694 EESYAKCATAEEKEKLLAECSTLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPE 758
             ..|.|....:|.||.|...:...:||||:.||...:.|.:||.:|.|:......|..|.||||.
  Rat   652 -GPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERPR 715

  Fly   759 AIKALKGMIDGAEKFLVTGRNLTKDTNPEK-DVFTQVEIDTLDKVITETNAWLKTETAAQKKLAK 822
            .::.|...:....|.....|.  ||   || :...:.|:..::|.:.|...|:.....||.|.:.
  Rat   716 VLEELGQRLQHYAKIAADFRG--KD---EKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSL 775

  Fly   823 NADIRLTVKDITDKMSLLDREVKYLVN--KIKIWKPKVK--PAAEKEKKKEEEVVASGSGDDTKS 883
            :.|..:...:|:.|:..|:...:.:|.  |.||..||::  |......|||:....|..|.|...
  Rat   776 HQDPVVRTHEISAKVKELNNVCEPVVTQPKPKIESPKLERTPNGPNMDKKEDLEGKSNLGADAPH 840

  Fly   884 EDAE 887
            ::.|
  Rat   841 QNGE 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	181/644 (28%)
		HYOU1-like_NBD	23..409	CDD:212672	124/394 (31%)
		TAF4	<572..>627	CDD:296797	17/66 (26%)
Hsph1	NP_001011901.1	HSPH1_NBD	2..384	CDD:212689	126/399 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..585		23/122 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..858		14/44 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810