DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and Hspa4

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_705893.1	Gene:	Hspa4 / 266759	RGDID:	628878	Length:	840	Species:	Rattus norvegicus

Alignment Length:	928	Identity:	250/928 - (26%)
Similarity:	428/928 - (46%)	Gaps:	115/928 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYG 85
            :|:.:|||.:...|.|...| .:|...|..|.|.|||.::|....|::|..|::..|.:..:...
  Rat     2 SVVGIDLGFQSCYVAVARAG-GIETIANEYSDRCTPACVSFGPKNRSVGAAAKSQVISNAKNTVQ 65

  Fly    86 YLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNT---VVFRKSDTDEFSVEELVAQLLVKAKQF 147
            ......|:...:|.|:..:.... |:||..|...|   |.:.:.:.: |:.|::.|.||.|.|:.
  Rat    66 GFKRFHGRAFSDPFVEAEKSNLA-YDIVQLPTGLTGIKVTYMEEERN-FTTEQVTAMLLSKLKET 128

  Fly   148 AQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRG--EINE 210
            |:..:::|:.:||::||.::..|||.:::.|.|:|.|..|:|:|:..||||.||::.:.  .:.|
  Rat   129 AESVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEE 193

  Fly   211 TAQYFLFYDMG--AYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQ 273
            ..:..:|.|||  ||:.|....:...:|            ||...:|.||||.:....|.::..:
  Rat   194 KPRNVVFVDMGHSAYQVSVCAFNRGKLK------------VLATAFDTTLGGRKFDEVLVNHFCE 246

  Fly   274 EFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSAN-TEFFAQIENLIEDIDFKLPVTREKLEQL 337
            ||.  ||.|.|:.:..|||.:|.:|..:||.::||| ::....||..:.|||....:.|.|..::
  Rat   247 EFG--KKYKLDIKSKVRALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEM 309

  Fly   338 CEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESATM 402
            |:||..|...||...|..|.|..:.|..|.:.||.||:|.|:|.|.....:||...|||||:.|.
  Rat   310 CDDLLARVEPPLRSILDQSKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTR 374

  Fly   403 GAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITF- 466
            |...:.|.||..|||::|.:.|...:|:.:.:.....:|::..:|    |...:..|..||:||
  Rat   375 GCALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEV----FPKNHAAPFSKVLTFY 435

  Fly   467 NKHTDDFEFYVN------YAD--LDRYSKEEIAALGSLNVTKVQLK---QVKELLEKSKKELVDN 520
            .|.....|.|.:      |.|  :.::|.:::......:.:||::|   .|..:...|...||:
  Rat   436 RKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVE- 499

  Fly   521 KGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEE 585
                                  |::.::.|:..:.|....              ||:|...:|||
  Rat   500 ----------------------VHKSEESEEPMETDQNAK--------------EEEKMQVDQEE 528

  Fly   586 AANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQD--TEAKNETIKLVTVKSPVTYESQTQFVVP 648
            .....::|....:| ||:.|:....|...:..|.|  .:||...:|..||..|:..:...|....
  Rat   529 PHTEEQQPQTPAEN-KAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLPIESQLLWQLDRE 592

  Fly   649 LVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAEC 713
            ::| .|.::..|:...:|.|::|   ..|.||:|.::.|::.||..| |.|..:.:::.....:.
  Rat   593 MLG-LYTENEGKMIMQDKLEKER---NDAKNAVEEYVYEMRDKLSGE-YEKFVSEDDRNNFTLKL 652

  Fly   714 STLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVTGR 778
            .....|||||.||...::|.:|||:|:.|......|..|.||||:..:.|...|....|.:.:.:
  Rat   653 EDTENWLYEDGEDQPKQVYVDKLAELRTLGQPIKTRFQESEERPKLFEELGKQIQQYMKVISSFK 717

  Fly   779 NLTKDTNPEKDVFTQVEIDTLDKVITETN---AWLKTETAAQKKLAKNADIRLTVKDITDKMSLL 840
            |       ::|.:..::...:.||...||   .|:.::...|.|.:..||..:..|:|..|:..|
  Rat   718 N-------KEDQYEHLDAADMTKVEKSTNEAMEWMNSKLNLQNKQSLTADPVVKTKEIEAKIKEL 775

  Fly   841 DREVKYLVNKIKIWKPKVKPAAEKEKKKEEEVVASGSGDDTKSEDAEQQQEQATKEEQQEQEPVD 905
            ......:::|.   ||||:|..|:.|..|:.....|.||:..::.||...:
  Rat   776 TNICSPIISKP---KPKVEPPKEEPKHAEQNGPVDGQGDNPGTQAAEHGAD-------------- 823

  Fly   906 EITPTPAEEETKTPHSEL 923
              |..|::.:.|.|..::
  Rat   824 --TAVPSDGDKKLPEMDI 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	173/624 (28%)
		HYOU1-like_NBD	23..409	CDD:212672	124/393 (32%)
		TAF4	<572..>627	CDD:296797	16/56 (29%)
Hspa4	NP_705893.1	HSPA4_NBD	2..384	CDD:212687	126/398 (32%)
		PTZ00121	<499..743	CDD:173412	68/293 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..575		20/89 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..840		18/78 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810