DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and HSPA12A

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001317093.1	Gene:	HSPA12A / 259217	HGNCID:	19022	Length:	692	Species:	Homo sapiens

Alignment Length:	421	Identity:	88/421 - (20%)
Similarity:	141/421 - (33%)	Gaps:	168/421 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 DYAAVALNYGVFHRGEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDR 256
            ||....|.|.:|  ||.        |.:....|..||.|...:..:.:.|...|         ||
Human   369 DYEFEKLLYKIF--GED--------FIEQFKIKRPAAWVDLMIAFESRKRAAAP---------DR 414

  Fly   257 TLGGLEIQLRLR--DYLAQEF------NALKKTKTD---------VTTSPRALAKLFKEAGRLKN 304
            | ..|.|.|...  ||. ::|      :||:|:..|         :..||.|:..|||..
Human   415 T-NPLNITLPFSFIDYY-KKFRGHSVEHALRKSNVDFVKWSSQGMLRMSPDAMNALFKPT----- 472

  Fly   305 VLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILF 369
                       |:::||.:               .||:   .||          .:..:..:.|.
Human   473 -----------IDSIIEHL---------------RDLF---QKP----------EVSTVKFLFLV 498

  Fly   370 GGGTRVPRVQETIKA--------VIKQELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDAT 426
            ||....|.:|:.::|        :|.|::|..                           ::|.|.
Human   499 GGFAEAPLLQQAVQAAFGDQCRIIIPQDVGLT---------------------------ILKGAV 536

  Fly   427 LFPLQVSFERDPGDGAAVKQVKRALF----ALMNPY------PQKKVITFNKH--TDDFEFYVNY 479
            ||.|      ||    ||.:|:|:..    .::|.|      |:|.::.....  ||.|:.::
Human   537 LFGL------DP----AVIKVRRSPLTYGVGVLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFI-- 589

  Fly   480 ADLDRYSKEEIAALGSL---NVTKVQLKQVKELLEKSKKELVDNKGIKAYFYLDDSGIFRC---- 537
                  |.::..|||.|   :.|..:..|:..::.....| .||..     ::.|.|:.:|
Human   590 ------SADQSVALGELVKRSYTPAKPSQLVIVINIYSSE-HDNVS-----FITDPGVKKCGTLR 642

  Fly   538 ---TGVEYVYEKQKPEDDADEDSTLSKFGST 565
               ||........:     .|..||.:||.|
Human   643 LDLTGTSGTAVPAR-----REIQTLMQFGDT 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	88/421 (21%)
		HYOU1-like_NBD	23..409	CDD:212672	49/241 (20%)
		TAF4	<572..>627	CDD:296797
HSPA12A	NP_001317093.1	HSPA12A_like_NBD	74..540	CDD:212685	53/262 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900