DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and Hspa5

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_037215.1	Gene:	Hspa5 / 25617	RGDID:	2843	Length:	654	Species:	Rattus norvegicus

Alignment Length:	700	Identity:	183/700 - (26%)
Similarity:	309/700 - (44%)	Gaps:	111/700 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLVLLLSALLAGIAL--------SQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPA 57
            ||..::.:|||...|:        .....|:.:|||:.:..|||...| .:||..|.:..|.||:
  Rat     1 MKFTVVAAALLLLCAVRAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNG-RVEIIANDQGNRITPS 64

  Fly    58 ILAFR-DGTRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTV 121
            .:||. :|.|.||:.|:.....:|.:.......|:|:|.::|.|....|..|:..:    |:.|.
  Rat    65 YVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV----EKKTK 125

  Fly   122 VFRKSD-----TDEFSVEELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQL 181
            .:.:.|     |..|:.||:.|.:|.|.|:.|:..:.:.:|..|:|||.||..|:|:|...|..:
  Rat   126 PYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTI 190

  Fly   182 ANLKVLQLINDYAAVALNYGVFHR-GEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINP 245
            |.|.|:::||:..|.|:.||:..| ||.|     .|.:|:|......::::..          |.
  Rat   191 AGLNVMRIINEPTAAAIAYGLDKREGEKN-----ILVFDLGGGTFDVSLLTID----------NG 240

  Fly   246 VVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANT 310
            |.:|:....|..|||.:...|:.::..:.:.  |||..||....||:.||.:|..:.|..||:..
  Rat   241 VFEVVATNGDTHLGGEDFDQRVMEHFIKLYK--KKTGKDVRKDNRAVQKLRREVEKAKRALSSQH 303

  Fly   311 EFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRV 375
            :...:||:..|..||...:||.|.|:|..||:....||:::.|..|.|....|::::|.||.||:
  Rat   304 QARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRI 368

  Fly   376 PRVQETIKAVIK-QELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPG 439
            |::|:.:|.... :|..:.:|.||:...||..:|..||........|:.|  :.||.:..|
  Rat   369 PKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLD--VCPLTLGIE---- 427

  Fly   440 DGAAVKQVKRALFALMNPYPQKKVITF-----NKHTDDFEFYVNYADLDRYSKEEIAALGSLNVT 499
               .|..|...|.......|.||...|     |:.|...:.|    :.:|...::...||:.::|
  Rat   428 ---TVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVY----EGERPLTKDNHLLGTFDLT 485

  Fly   500 KV--QLKQVKELLEKSKKELVDNKGIKAYFYLDDSGIFRCTGVEY-VYEKQK-----------PE 550
            .:  ..:.|.:              |:..|.:|.:||.|.|..:. ...|.|           ||
  Rat   486 GIPPAPRGVPQ--------------IEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPE 536

  Fly   551 D----------DADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGE-EPSKSEDNEKAKE 604
            :          .|:||..|.:...|.::|.:.....|....::|:.  .|: .|...|..|||.|
  Rat   537 EIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKL--GGKLSPEDKETMEKAVE 599

  Fly   605 EDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAY 654
            |.....:..:::..:|.:||.:.::              :.|.|::...|
  Rat   600 EKIEWLESHQDADIEDFKAKKKELE--------------EIVQPIISKLY 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	173/640 (27%)
		HYOU1-like_NBD	23..409	CDD:212672	120/393 (31%)
		TAF4	<572..>627	CDD:296797	13/55 (24%)
Hspa5	NP_037215.1	Required for interaction with KIAA1324. /evidence=ECO:0000250\|UniProtKB:P11021	1..80		26/79 (33%)
		HSPA5-like_NBD	28..403	CDD:212681	121/396 (31%)
		HSP70	30..635	CDD:278441	176/669 (26%)
		Nucleotide-binding (NBD). /evidence=ECO:0000250\|UniProtKB:P11021	125..280		50/171 (29%)
		Interdomain linker. /evidence=ECO:0000250\|UniProtKB:G3I8R9	409..419		2/11 (18%)
		Substrate-binding (SBD). /evidence=ECO:0000250\|UniProtKB:P11021	420..500		19/104 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..654		0/4 (0%)
		Prevents secretion from ER	651..654
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810