DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and lsh1

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_592867.1	Gene:	lsh1 / 2541537	PomBaseID:	SPAC1F5.06	Length:	848	Species:	Schizosaccharomyces pombe

Alignment Length:	943	Identity:	233/943 - (24%)
Similarity:	420/943 - (44%)	Gaps:	176/943 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAY 84
            ::|:::|.|:||.|..::.||:|:||.|.::::||..:.:||:...|..|.||..:..:.|..:.
pombe    22 SSVLAIDYGTEWTKAALIKPGIPLEIVLTKDTRRKEQSAVAFKGNERIFGVDASNLATRFPAHSI 86

  Fly    85 GYLLDLLGKT-IDNPIVDLYRKRFPYYNIVGDPERNT-VVFRKSDTDEFSVEELVAQLLVKAKQF 147
            ..:.:||... :::.:|..|:..:|...:|.:.|..: :.|..||.:.:|:||::|..:......
pombe    87 RNVKELLDTAGLESVLVQKYQSSYPAIQLVENEETTSGISFVISDEENYSLEEIIAMTMEHYISL 151

  Fly   148 AQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINETA 212
            |:|...:.||:.|||||.:|.:.:|..||.||::.|..||.||:|..|||:.|.:......:.|
pombe   152 AEEMAHEKITDLVLTVPPHFNELQRSILLEAARILNKHVLALIDDNVAVAIEYSLSRSFSTDPT- 215

  Fly   213 QYFLFYDMGAYKTSAAVVSYQLV-------KDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDY 270
             |.:.||.|:..|||.|:|:..|       |...||     ::.|..|:...|.|.||..:|..:
pombe   216 -YNIIYDSGSGSTSATVISFDTVEGSSLGKKQNITR-----IRALASGFTLKLSGNEINRKLIGF 274

  Fly   271 LAQEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLE 335
            :...|  .:|...|::.:.||||:|.|||.|:|::||||:|..|.||.|.:.|||:|.:||..||
pombe   275 MKNSF--YQKHGIDLSHNHRALARLEKEALRVKHILSANSEAIASIEELADGIDFRLKITRSVLE 337

  Fly   336 QLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQE-LGKNLNADES 399
            .||:|:...|.:|:.:||..::|:...||.:|||||.:|:|.:|.|:...:..: :.||:||||:
pombe   338 SLCKDMEDAAVEPINKALKKANLTFSEINSIILFGGASRIPFIQSTLADYVSSDKISKNVNADEA 402

  Fly   400 ATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFAL--MNPYPQKK 462
            :..||.:..|.|:..|:||..:|:|...:|..:|.           .....:.||  ..||..:.
pombe   403 SVKGAAFYGASLTKSFRVKPLIVQDIINYPYLLSL-----------GTSEYIVALPDSTPYGMQH 456

  Fly   463 VITFNKHTDDFEFYVNYADLDRYSKEEIAALGSL-------NVTKVQLKQVKELLEKSKKELVDN 520
            .:|.:          |.:.:.::....::..|.|       |:|.|:           |.....|
pombe   457 NVTIH----------NVSTIGKHPSFPLSNNGELIGEFTLSNITDVE-----------KVCACSN 500

  Fly   521 KGIKAYFYLDD--------SGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEK 577
            |.|:..|..|.        |.|..|              :..|.|:..|.|..:..||....|..
pombe   501 KNIQISFSSDRTKGILVPLSAIMTC--------------EHGELSSKHKLGDRVKSLFGSHDESG 551

  Fly   578 KDNSEQEEAANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQ 642
            ..|:|........::..:..||                           .::|.:
pombe   552 LRNNESYPIGFTYKKYGEMSDN---------------------------ALRLAS---------- 579

  Fly   643 TQFVVPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKE 707
                            |||....:.::.:...::|.|.||..:...|..:|::.:.:.|..||.:
pombe   580 ----------------AKLERRLQIDKSKAAHDNALNELETLLYRAQAMVDDDEFLEFANPEETK 628

  Fly   708 KLLAECSTLGEWLYE-DLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPE---AIKALKGMID 768
            .|..:.....:||.| ..:.|.:|:.:    :.|||.:...:..:..::..:   :::..|..::
pombe   629 ILKNDSVESYDWLIEYGSQSPTSEVTD----RYKKLDDTLKSISFRFDQAKQFNTSLENFKNALE 689

  Fly   769 GAEKFLVTGRNLTKDTNP-----EKDVFTQVEIDTL---------DKVITETNAWLKTETAAQKK 819
            .||..|.   |......|     ||||   ..:::|         ::...:|. |||....:...
pombe   690 RAESLLT---NFDVPDYPLNVYDEKDV---KRVNSLRGTSYKKLGNQYYNDTQ-WLKDNLDSHLS 747

  Fly   820 LAKNADIRLTVKDITDKMSLLDREVKYLVNKIKIWKPKVK------PAAEKEKKKEEE-----VV 873
            ...:.|..:.|:::.:|...| :|:.|...:..:.:||:|      .::..|.|.|:|     :.
pombe   748 HTLSEDPLIKVEELEEKAKRL-QELTYEYLRRSLQQPKLKAKKGASSSSTAESKVEDETFTNDIE 811

  Fly   874 ASGSGDDTKSEDAEQQQEQATKEEQQEQEPVDE 906
            .:.:.:.|.:::.|:.:...|:.....|:.:|:
pombe   812 PTTALNSTSTQETEKSRASVTQRPSSLQQEIDD 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	178/629 (28%)
		HYOU1-like_NBD	23..409	CDD:212672	137/395 (35%)
		TAF4	<572..>627	CDD:296797	5/54 (9%)
lsh1	NP_592867.1	DnaK	19..667	CDD:223520	200/756 (26%)
lsh1	NP_592867.1	HYOU1-like_NBD	25..412	CDD:212672	137/395 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	257	1.000	Domainoid score	I383
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54551
OrthoFinder	1	1.000	-	-		FOG0003505
OrthoInspector	1	1.000	-	-		oto100702
orthoMCL	1	0.900	-	-		OOG6_101811
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3997
SonicParanoid	1	1.000	-	-		X2877
TreeFam	1	0.960	-	-
	10	9.800