DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2918 and Hspa1a

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_114177.2	Gene:	Hspa1a / 24472	RGDID:	1593284	Length:	641	Species:	Rattus norvegicus

Alignment Length:	764	Identity:	188/764 - (24%)
Similarity:	327/764 - (42%)	Gaps:	162/764 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 MSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYGYL 87
            :.:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|.:.....
  Rat     7 IGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDA 70

  Fly    88 LDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTV-VFRKSDTDEFSVEELVAQLLVKAKQFAQES 151
            ..|:|:...:|:|....|.:| :.:|.|.::..| |..|.:...|..||:.:.:|.|.|:.|:..
  Rat    71 KRLIGRKFGDPVVQSDMKHWP-FQVVNDGDKPKVQVNYKGENRSFYPEEISSMVLTKMKEIAEAY 134

  Fly   152 VQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFH--RGEINETAQY 214
            :..|:|..|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||:..  :||.|
  Rat   135 LGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERN----- 194

  Fly   215 FLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALK 279
            .|.:|:|......::::..          :.:.:|.....|..|||.:...||..:..:||.  :
  Rat   195 VLIFDLGGGTFDVSILTID----------DGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFK--R 247

  Fly   280 KTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPR 344
            |.|.|::.:.||:.:|.....|.|..||::|:...:|::|.|.|||...:||.:.|:||.||:..
  Rat   248 KHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRG 312

  Fly   345 ATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATMGAVYKA 408
            ..:|:|:||..:.|....|:.::|.||.||:|:||:.::.... ::|.|::|.||:...||..:|
  Rat   313 TLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQA 377

  Fly   409 ADLSAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFNKHT 470
            |.|...   |...|:|..|.   ||.:..|...|       |..||....:..|.|:..||..::
  Rat   378 AILMGD---KSENVQDLLLLDVAPLSLGLETAGG-------VMTALIKRNSTIPTKQTQTFTTYS 432

  Fly   471 DD-----FEFYVNYADLDRYSKEEIAALGSLNVTKV--QLKQVKELLEKSKKELVDNKGIKAYFY 528
            |:     .:.|    :.:|....:...||...::.:  ..:.|.:              |:..|.
  Rat   433 DNQPGVLIQVY----EGERAMTRDNNLLGRFELSGIPPAPRGVPQ--------------IEVTFD 479

  Fly   529 LDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEP 593
            :|.:||...|              |.:.||                               |:..
  Rat   480 IDANGILNVT--------------ATDKST-------------------------------GKAN 499

  Fly   594 SKSEDNEK---AKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYD 655
            ..:..|:|   :|||.....|::|....:|
  Rat   500 KITITNDKGRLSKEEIERMVQEAERYKAED----------------------------------- 529

  Fly   656 QSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWL 720
                        |.||.|: :|.||||::...::..:::|......:..:|:|:|.:|..:..||
  Rat   530 ------------EVQRERV-AAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWL 581

  Fly   721 YEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEA----IKALKG 765
            ..:....|.| :..|..:|:::.|..::..::....|.|    .:|.||
  Rat   582 DSNTLAEKEE-FVHKREELERVCNPIISGLYQGAGAPGAGGFGAQAPKG 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	162/618 (26%)
		HYOU1-like_NBD	23..409	CDD:212672	120/389 (31%)
		TAF4	<572..>627	CDD:296797	9/57 (16%)
Hspa1a	NP_114177.2	PTZ00009	1..641	CDD:240227	188/764 (25%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		124/400 (31%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	122/392 (31%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		29/184 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..641		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910