DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2918 and Hspa8

DIOPT Version :9

Sequence 1:NP_001162645.1 Gene:CG2918 / 31215 FlyBaseID:FBgn0023529 Length:923 Species:Drosophila melanogaster
Sequence 2:NP_077327.1 Gene:Hspa8 / 24468 RGDID:621725 Length:646 Species:Rattus norvegicus


Alignment Length:756 Identity:190/756 - (25%)
Similarity:333/756 - (44%) Gaps:163/756 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LSQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDP 80
            :|:|.|| .:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|
  Rat     1 MSKGPAV-GIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNP 63

  Fly    81 NSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTV-VFRKSDTDEFSVEELVAQLLVKA 144
            .:.......|:|:..|:.:|....|.:|:. :|.|..|..| |..|.:|..|..||:.:.:|.|.
  Rat    64 TNTVFDAKRLIGRRFDDAVVQSDMKHWPFM-VVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKM 127

  Fly   145 KQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHR--GE 207
            |:.|:..:.:.:|..|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||:..:  .|
  Rat   128 KEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAE 192

  Fly   208 INETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLA 272
            .|     .|.:|:|......::::.:          :.:.:|.....|..|||.:...|:.::..
  Rat   193 RN-----VLIFDLGGGTFDVSILTIE----------DGIFEVKSTAGDTHLGGEDFDNRMVNHFI 242

  Fly   273 QEFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQL 337
            .||.  :|.|.|::.:.||:.:|.....|.|..||::|:...:|::|.|.|||...:||.:.|:|
  Rat   243 AEFK--RKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEEL 305

  Fly   338 CEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESAT 401
            ..||:.....|:|:||..:.|....|:.::|.||.||:|::|:.::.... :||.|::|.||:..
  Rat   306 NADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVA 370

  Fly   402 MGAVYKAADLSAGFK---VKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKV 463
            .||..:||.|| |.|   |:..::.|.|  ||.:..|...|       |...|.......|.|:.
  Rat   371 YGAAVQAAILS-GDKSENVQDLLLLDVT--PLSLGIETAGG-------VMTVLIKRNTTIPTKQT 425

  Fly   464 ITFNKHTDD-----FEFYVNYADLDRYSKEEIAALGSLNVTKVQ-----LKQVKELLEKSKKELV 518
            .||..::|:     .:.|    :.:|...::...||...:|.:.     :.|::...:      :
  Rat   426 QTFTTYSDNQPGVLIQVY----EGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFD------I 480

  Fly   519 DNKGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQ 583
            |..||     |:.|.:.:.||.|                  :|...|..|     |...|::.|:
  Rat   481 DANGI-----LNVSAVDKSTGKE------------------NKITITNDK-----GRLSKEDIER 517

  Fly   584 --EEAANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFV 646
              :||             ||.|.||                                        
  Rat   518 MVQEA-------------EKYKAED---------------------------------------- 529

  Fly   647 VPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLA 711
                                 |:||.::.|. |:||::...::..:::|........|:|:|:|.
  Rat   530 ---------------------EKQRDKVSSK-NSLESYAFNMKATVEDEKLQGKINDEDKQKILD 572

  Fly   712 ECSTLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWE 752
            :|:.:..||.::....|.| :|.:..:|:|:.|..:.:.::
  Rat   573 KCNEIISWLDKNQTAEKEE-FEHQQKELEKVCNPIITKLYQ 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2918NP_001162645.1 HSP70 22..625 CDD:278441 166/621 (27%)
HYOU1-like_NBD 23..409 CDD:212672 118/389 (30%)
TAF4 <572..>627 CDD:296797 10/56 (18%)
Hspa8NP_077327.1 PTZ00009 1..613 CDD:240227 190/756 (25%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 128/404 (32%)
Interaction with BAG1. /evidence=ECO:0000250 186..377 57/207 (28%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 30/161 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..646
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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