DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2918 and HSPA4L

DIOPT Version :9

Sequence 1:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster
Sequence 2:	NP_001304310.1	Gene:	HSPA4L / 22824	HGNCID:	17041	Length:	870	Species:	Homo sapiens

Alignment Length:	903	Identity:	272/903 - (30%)
Similarity:	431/903 - (47%)	Gaps:	97/903 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQT-IGIKDPNS 82
            |.:|:.:|||.....:.|...| .:|...|..|.|.|||.::....||.||..|:: |.....|:
Human    31 GMSVVGIDLGFLNCYIAVARSG-GIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNT 94

  Fly    83 AYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDE--FSVEELVAQLLVKAK 145
            .:|: ..|.|::.|:|||...|.|.| |.:...|..:..|..:...:|  |::|::...||.|.|
Human    95 IHGF-KKLHGRSFDDPIVQTERIRLP-YELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLK 157

  Fly   146 QFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRG--EI 208
            :.::.::::|:.:||:::|.:|..|||.::::|||:|.|..|:|:|:..||||.||::.:.  .:
Human   158 ETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPL 222

  Fly   209 NETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQ 273
            :|..:..:|.|||.......|.::...|          ::||...:|..|||......|.||...
Human   223 DEKPRNVVFIDMGHSAYQVLVCAFNKGK----------LKVLATTFDPYLGGRNFDEALVDYFCD 277

  Fly   274 EFNALKKTKTDVTTSPRALAKLFKEAGRLKNVLSAN-TEFFAQIENLIEDIDFKLPVTREKLEQL 337
            ||..  |.|.:|..:.|||.:|::|..:||.::||| ::....||..:.|:|....:.|.:.|||
Human   278 EFKT--KYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQL 340

  Fly   338 CEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIKQELGKNLNADESATM 402
            |..|..|...||:..:..::|..:.|:.:.:.||.||:|.|:|.|.....:::...|||||:...
Human   341 CASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFLKDISTTLNADEAVAR 405

  Fly   403 GAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFN 467
            |...:.|.||..|||::|.:.|...:.:.:.::....||:...:|    |...:|.|..|||||:
Human   406 GCALQCAILSPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEV----FCKNHPAPFSKVITFH 466

  Fly   468 KHTDDFE---FYVN-----YADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKGIK 524
            | .:.||   ||.|     |.|         |.:||..:..|        ..:|..   |:..:|
Human   467 K-KEPFELEAFYTNLHEVPYPD---------ARIGSFTIQNV--------FPQSDG---DSSKVK 510

  Fly   525 AYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNS-----EQE 584
            ....::..|||...... |.|||..|.|..:....::         |....|.|||.     :||
Human   511 VKVRVNIHGIFSVASAS-VIEKQNLEGDHSDAPMETE---------TSFKNENKDNMDKMQVDQE 565

  Fly   585 EAANAGEEPSKSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKS---PVTYESQTQFV 646
            |    |.:...:|...:.:.:....:.||..|.|||  ..|:|:|...|||   |:......|..
Human   566 E----GHQKCHAEHTPEEEIDHTGAKTKSAVSDKQD--RLNQTLKKGKVKSIDLPIQSSLCRQLG 624

  Fly   647 VPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLA 711
            ..|:.| |.::..|:...:|.|::|   ..|.||:|.::.:.:.:|. ..|.|..|.|:..||.|
Human   625 QDLLNS-YIENEGKMIMQDKLEKER---NDAKNAVEEYVYDFRDRLG-TVYEKFITPEDLSKLSA 684

  Fly   712 ECSTLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVT 776
            .......|||||.||...::|.:||.:|||.......::.||||||:|:..|...|....|.:..
Human   685 VLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEA 749

  Fly   777 GRNLTKDTNPEKDVFTQVEIDTLDKVITETNAWLKTETAAQKKLAKNADIRLTVKDITDKMSLLD 841
            .||  ||  ...|.....|::.::|.|::..:||.::..||.||:...|..:.|.:|..|...||
Human   750 YRN--KD--ERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVAKSKELD 810

  Fly   842 REVKYLVNKIKIWKPKVKPAAEKEKKK---EEEVVASG-SGDDTKSEDAEQQQEQATK 895
            .    ..|.| |:|||.|....::|.|   |......| ||.:||| |:.:...|.||
Human   811 N----FCNPI-IYKPKPKAEVPEDKPKANSEHNGPMDGQSGTETKS-DSTKDSSQHTK 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	181/621 (29%)
		HYOU1-like_NBD	23..409	CDD:212672	121/391 (31%)
		TAF4	<572..>627	CDD:296797	16/59 (27%)
HSPA4L	NP_001304310.1	HSPA4L_NBD	33..415	CDD:212688	123/396 (31%)
HSPA4L	NP_001304310.1	HSP70	34..725	CDD:278441	221/751 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810