DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2918 and Hspa1a

DIOPT Version :9

Sequence 1:NP_001162645.1 Gene:CG2918 / 31215 FlyBaseID:FBgn0023529 Length:923 Species:Drosophila melanogaster
Sequence 2:NP_034609.2 Gene:Hspa1a / 193740 MGIID:96244 Length:641 Species:Mus musculus


Alignment Length:765 Identity:185/765 - (24%)
Similarity:326/765 - (42%) Gaps:164/765 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 MSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYGYL 87
            :.:|||:.:..|||...| .:||..|.:..|.||:.:||.|..|.||:.|:.....:|.:.....
Mouse     7 IGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDA 70

  Fly    88 LDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTV-VFRKSDTDEFSVEELVAQLLVKAKQFAQES 151
            ..|:|:...:.:|....|.:| :.:|.|.::..| |..|.::..|..||:.:.:|.|.|:.|:..
Mouse    71 KRLIGRKFGDAVVQSDMKHWP-FQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKEIAEAY 134

  Fly   152 VQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFH--RGEINETAQY 214
            :..|:|..|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||:..  :||.|     
Mouse   135 LGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERN----- 194

  Fly   215 FLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALK 279
            .|.:|:|......::::..          :.:.:|.....|..|||.:...||..:..:||.  :
Mouse   195 VLIFDLGGGTFDVSILTID----------DGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFK--R 247

  Fly   280 KTKTDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPR 344
            |.|.|::.:.||:.:|.....|.|..||::|:...:|::|.|.|||...:||.:.|:||.||:..
Mouse   248 KHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRG 312

  Fly   345 ATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATMGAVYKA 408
            ..:|:|:||..:.:....|:.::|.||.||:|:||:.::.... ::|.|::|.||:...||..:|
Mouse   313 TLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQA 377

  Fly   409 ADLSAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFNKHT 470
            |.|...   |...|:|..|.   ||.:..|...|       |..||....:..|.|:..||..::
Mouse   378 AILMGD---KSENVQDLLLLDVAPLSLGLETAGG-------VMTALIKRNSTIPTKQTQTFTTYS 432

  Fly   471 DD-----FEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKG---IKAYF 527
            |:     .:.|    :.:|....:...||...::.:....               :|   |:..|
Mouse   433 DNQPGVLIQVY----EGERAMTRDNNLLGRFELSGIPPAP---------------RGVPQIEVTF 478

  Fly   528 YLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEE 592
            .:|.:||...|              |.:.||                               |:.
Mouse   479 DIDANGILNVT--------------ATDKST-------------------------------GKA 498

  Fly   593 PSKSEDNEK---AKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAY 654
            ...:..|:|   :|||.....|::|....:|                                  
Mouse   499 NKITITNDKGRLSKEEIERMVQEAERYKAED---------------------------------- 529

  Fly   655 DQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEW 719
                         |.||.|: :|.||||::...::..:::|......:..:|:|:|.:|..:..|
Mouse   530 -------------EVQRDRV-AAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISW 580

  Fly   720 LYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEA----IKALKG 765
            |..:....|.| :..|..:|:::.:..::..::....|.|    .:|.||
Mouse   581 LDSNTLADKEE-FVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPKG 629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2918NP_001162645.1 HSP70 22..625 CDD:278441 160/619 (26%)
HYOU1-like_NBD 23..409 CDD:212672 118/389 (30%)
TAF4 <572..>627 CDD:296797 9/57 (16%)
Hspa1aNP_034609.2 PTZ00009 1..641 CDD:240227 185/765 (24%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 122/400 (31%)
HSPA1-2_6-8-like_NBD 6..381 CDD:212675 120/392 (31%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 29/185 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..641 4/12 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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